Patents by Inventor Calvin E. Higgens

Calvin E. Higgens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A-40104 Antibiotics and process for production thereof
    Patent number: 4247542
    Abstract: A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C.sub.2 -C.sub.6)alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: January 27, 1981
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Calvin E. Higgens
  • Antibiotic A16886 and process for production thereof
    Patent number: 4191763
    Abstract: Antibiotic A16886I and antibiotic A16886II and their salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces clavuligerus NRRL 3585.
    Type: Grant
    Filed: May 20, 1976
    Date of Patent: March 4, 1980
    Assignee: Eli Lilly and Company
    Inventors: Marvin Gorman, Calvin E. Higgens, Ramakrishnan Nagarajan
  • 7-(5-Amino-5-carboxyvaler-amido)-3-(carbamoyloxymethyl)-7-methoxy-3-cep hem-4-carboxylic acid
    Patent number: 4173702
    Abstract: Antibiotic A16886I and antibiotic A16886II and their salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces clavuligerus NRRL 3585.
    Type: Grant
    Filed: August 10, 1970
    Date of Patent: November 6, 1979
    Assignee: Eli Lilly and Company
    Inventors: Marvin Gorman, Calvin E. Higgens, Ramakrishnan Nagarajan
  • Antibiotic A16886II
    Patent number: 4132790
    Abstract: Antibiotic A16886I and antibiotic A16886II and their salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces clavuligerus NRRL 3585.
    Type: Grant
    Filed: May 20, 1976
    Date of Patent: January 2, 1979
    Assignee: Eli Lilly and Company
    Inventors: Marvin Gorman, Calvin E. Higgens, Ramakrishnan Nagarajan
  • A-40104 antibiotics and process for production thereof
    Patent number: 4129721
    Abstract: A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors, A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C.sub.2 -C.sub.6)alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: December 12, 1978
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Calvin E. Higgens
  • 7-(5-Am ino-5-carboxyvaleramido)-3-(carbamoyoloxymethyl)-3-cephem-4-carboxylic acid
    Patent number: 4123612
    Abstract: Antibiotic A16886I and antibiotic A16886II and their salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces clavuligerus NRRL 3585.
    Type: Grant
    Filed: April 23, 1974
    Date of Patent: October 31, 1978
    Assignee: Eli Lilly and Company
    Inventors: Marvin Gorman, Calvin E. Higgens, Ramakrishnan Nagarajan
  • Antibiotic A-35512 and process for production thereof
    Patent number: 4122168
    Abstract: Antibiotic A-35512 complex, comprising microbiologically active, related factors A, B, C, E and H, is produced by submerged aerobic fermentation of Streptomyces candidus NRRL 8156. The individual A-35512 factors are separated and isolated by chromatography. The A-35512 antibiotics are antibacterial and growth-promoting agents and increase feed-utilization efficiency in animals. In addition, A-35512 factor B is useful in the treatment of dental caries and acne.
    Type: Grant
    Filed: May 23, 1977
    Date of Patent: October 24, 1978
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Calvin E. Higgens
  • Antibiotic A-35512 for increasing feed utilization efficiency in an animal
    Patent number: 4083964
    Abstract: Antibiotic A-35512 complex, comprising microbiologically active, related factors A, B, C, E and H, is produced by submerged aerobic fermentation of Streptomyces candidus NRRL 8156. The individual A-35512 factors are separated and isolated by chromatography. The A-35512 antibiotics are antibacterial and growth-promoting agents and increase feed-utilization efficiency in animals. In addition, A-35512 factor B is useful in the treatment of dental caries and acne.
    Type: Grant
    Filed: September 13, 1976
    Date of Patent: April 11, 1978
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Calvin E. Higgens
  • 7-(5-Amino-5-carboxyvaleramido)-7-methoxycephalosporanic acid
    Patent number: 4054564
    Abstract: Antibiotic A16884 and its salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces lipmanii NRRL 3584.
    Type: Grant
    Filed: May 8, 1972
    Date of Patent: October 18, 1977
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Calvin E. Higgens, Marvin M. Hoehn
  • Antibiotic A-22082 and process for production thereof
    Patent number: 4024246
    Abstract: Antibiotic A-22082 is produced by submerged aerobic fermentation of Aspergillus nidulans NRRL 8112. Antibiotic A-22082 is an antifungal agent.
    Type: Grant
    Filed: August 25, 1976
    Date of Patent: May 17, 1977
    Assignee: Eli Lilly and Company
    Inventors: Calvin E. Higgens, Karl H. Michel
  • Antibiotic A16884
    Patent number: 3973015
    Abstract: Antibiotic A16884 and its salts, having antibacterial and anthelmintic activity, prepared by fermentation of Streptomyces lipmanii NRRL 3584.
    Type: Grant
    Filed: May 8, 1972
    Date of Patent: August 3, 1976
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Calvin E. Higgens, Marvin M. Hoehn
  • Antibiotic A23187 and process for preparation thereof
    Patent number: 3960667
    Abstract: Antibiotic A23187 and process for production thereof by submerged aerobic culture of Streptomyces chartreusis NRRL 3882. The antibiotic demonstrates antimicrobial activity and exhibits ionophorous properties, with a specificity for divalent cations.
    Type: Grant
    Filed: July 8, 1975
    Date of Patent: June 1, 1976
    Assignee: Eli Lilly and Company
    Inventors: Richard M. Gale, Calvin E. Higgens, Marvin M. Hoehn