Patents by Inventor Calvin Lawrence Becker

Calvin Lawrence Becker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY DRUG CONJUGATE (ADC) PURIFICATION
    Publication number: 20190262417
    Abstract: The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 29, 2019
    Inventors: Marvin Robert Leanna, Calvin Lawrence Becker
  • ANTIBODY DRUG CONJUGATE (ADC) PURIFICATION
    Publication number: 20140286968
    Abstract: The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Inventors: Marvin Robert Leanna, Calvin Lawrence Becker