Abstract: A fluid delivery system includes a housing including cartridge reservoir, a fluid containing cartridge removably receivable in the cartridge reservoir, and a gasket disposed in the cartridge reservoir in a position to engage with the fluid containing cartridge. The gasket includes at least one biasing portion that is flexible in an insertion direction of the fluid containing cartridge when the fluid containing cartridge is received in the cartridge reservoir. The at least one biasing portion of the gasket facilitates air flow from the cartridge reservoir while flexing in the insertion direction.