Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: Disclosed are methods of treating a cancer in a subject using an ATR inhibitor and PARP inhibitor. wherein the cancer has been previously identified as a cancer having a loss of function of ATM, BRCA2, RNAse H2A, RNAse H2B, CDK12, or a combination thereof, or as an ALT+ cancer. Also disclosed are methods of inducing cell death in an aberrant cancer cell having a loss of function of ATM, BRCA2, RNAse H2A, RNAse H2B, CDK12, or a combination thereof, or an ALT+ cancer cell, by contacting the cell with an effective amount of an ATR inhibitor and PARP inhibitor.

Abstract: A lighting system is disclosed that includes elongated LED light fixture with one or more master circuit boards configured to power light emitting diodes. The elongated LED light fixtures include modular light boards with arrays of light emitting diodes that interchangeably couple to the matched connectors on the master circuit board. The system further includes elongated LED light fixtures with telescoping end features, fenestrated diffuser optics at ends of the elongated LED fight fixtures and/or pivoting corner features that join sections of the elongated LED light fixtures.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: A lighting system is disclosed that includes elongated LED light fixture with one or more master circuit boards configured to power light emitting diodes. The elongated LED light fixtures include modular light boards with arrays of light emitting diodes that interchangeably couple to the matched connectors on the master circuit board. The system further includes elongated LED light fixtures with telescoping end features, fenestrated diffuser optics at ends of the elongated LED fight fixtures and/or pivoting corner features that join sections of the elongated LED light fixtures.

Abstract: A lighting system is disclosed that includes elongated LED light fixture with one or more master circuit boards configured to power light-emitting diodes. The elongated LED light fixtures include modular light boards, with arrays of light-emitting diodes, that interchangeably couple to the matched connectors on the master circuit board. The system further includes elongated LED light fixtures with telescoping end features, fenestrated diffuser optics at ends of the elongated LED fight fixtures, and/or pivoting corner features that join sections of the elongated LED light fixtures.

Abstract: A lighting system is disclosed that includes elongated LED light fixture with one or more master circuit boards configured to power light-emitting diodes. The elongated LED light fixtures include modular light boards, with arrays of light-emitting diodes, that interchangeably couple to the matched connectors on the master circuit board. The system further includes elongated LED light fixtures with telescoping end features, fenestrated diffuser optics at ends of the elongated LED fight fixtures, and/or pivoting corner features that join sections of the elongated LED light fixtures.

Abstract: A lighting system is disclosed that includes elongated LED light fixture with one or more master circuit boards configured to power light emitting diodes. The elongated LED light fixtures include modular light boards with arrays of light emitting diodes that interchangeably couple to the matched connectors on the master circuit board. The system further includes elongated LED light fixtures with telescoping end features, fenestrated diffuser optics at ends of the elongated LED fight fixtures and/or pivoting corner features that join sections of the elongated LED light fixtures.

Abstract: A lighting system is disclosed that includes elongated LED light fixture with one or more master circuit boards configured to power light emitting diodes. The elongated LED light fixtures include modular light boards with arrays of light emitting diodes that interchangeably couple to the matched connectors on the master circuit board. The system further includes elongated LED light fixtures with telescoping end features, fenestrated diffuser optics at ends of the elongated LED fight fixtures and/or pivoting corner features that join sections of the elongated LED light fixtures.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: A lighting system is disclosed that includes elongated LED light fixture with one or more master circuit boards configured to power light emitting diodes. The elongated LED light fixtures include modular light boards with arrays of light emitting diodes that interchangeably couple to the matched connectors on the master circuit board. The system further includes elongated LED light fixtures with telescoping end features, fenestrated diffuser optics at ends of the elongated LED fight fixtures and/or pivoting corner features that join sections of the elongated LED light fixtures.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: A lighting system is disclosed that includes elongated LED light fixture with one or more master circuit boards configured to power light emitting diodes. The elongated LED light fixtures include modular light boards with arrays of light emitting diodes that interchangeably couple to the matched connectors on the master circuit board. The system further includes elongated LED light fixtures with telescoping end features, fenestrated diffuser optics at ends of the elongated LED fight fixtures and/or pivoting corner features that join sections of the elongated LED light fixtures.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.