Patents by Inventor Cameron J. Cowden

Cameron J. Cowden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED JAK INHIBITORS
    Publication number: 20230322787
    Abstract: Certain aspects of the present invention are directed to improved processes for preparing enantiomerically enriched intermediates for the synthesis of ruxolitinib and deuterated forms of ruxolitinib. Certain aspects are also directed to deuterated intermediates useful in the synthesis of deuterated forms of ruxolitinib. Certain aspects are also directed to reaction mixtures for preparing enantiomerically enriched intermediates useful in the synthesis of ruxolitinib and deuterated forms of ruxolitinib.
    Type: Application
    Filed: August 12, 2021
    Publication date: October 12, 2023
    Inventors: Sean Wiedemann, Cameron J. Cowden, Patrick Bazinet, Kathryn E. Kavouris, Kuo-Ming Wu, Robert S. Lewis
  • PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED JAK INHIBITORS
    Publication number: 20220306636
    Abstract: Improved processes and intermediates for preparing ruxolitinib and deuterated analogs of ruxolitinib are disclosed.
    Type: Application
    Filed: February 6, 2020
    Publication date: September 29, 2022
    Inventors: Robert S. Lewis, Mahender Reddy Karla, Kathryn E. Kavouris, Yong Dong, Adam J. Morgan, Cameron J. Cowden
  • PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED JAK INHIBITORS
    Publication number: 20220213105
    Abstract: Improved processes and intermediates for preparing ruxolitinib and deuterated analogs of ruxolitinib are disclosed.
    Type: Application
    Filed: August 12, 2021
    Publication date: July 7, 2022
    Inventors: Robert S. Lewis, Mahender Reddy Karla, Kathryn E. Kavouris, Yong Dong, Adam J. Morgan, Cameron J. Cowden
  • Pyrazinone thrombin inhibitors
    Patent number: 6521625
    Abstract: Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and are selected from the group consisting of 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline Anhydrous Form B, 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline form Type A Monohydrate, and 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline form Type B monohydrate, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: February 18, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Cameron J. Cowden, V. Brett Cooper, Daniel J. Rush, Patricia Frech
  • Process for making a thrombin inhibitor
    Publication number: 20020103379
    Abstract: The invention is a process for preparing 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide which comprises coupling 1
    Type: Application
    Filed: December 6, 2001
    Publication date: August 1, 2002
    Inventors: Ulf H. Dolling, Ramon Alabaster, Michael S. Ashwood, Ian F. Cottrell, Cameron J. Cowden, Antony J. Davies, David Hands, Debra J. Wallace, Robert D. Wilson
  • Pyrazinone thrombin inhibitors
    Publication number: 20020004507
    Abstract: Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and are selected from the group consisting of 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline Anhydrous Form B, 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline form Type A Monohydrate, and 3-Fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide polymorphic crystalline form Type B monohydrate, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 31, 2001
    Publication date: January 10, 2002
    Inventors: Cameron J. Cowden, V. Brett Cooper, Daniel J. Rush, Patricia Frech
  • Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
    Publication number: 20010029297
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) 1
    Type: Application
    Filed: February 27, 2001
    Publication date: October 11, 2001
    Inventors: Michael S. Ashwood, Ian F. Cottrell, Cameron J. Cowden, Debra J. Wallace