Patents by Inventor Cameron J. Koch
Cameron J. Koch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12256032Abstract: A portable electronic device may include a housing having a wall defining an opening in the housing and at least a portion of four side surfaces of the portable electronic device. The portable electronic device may further include a display at least partially within the housing, a front cover positioned in the opening in the housing and over the display, the front cover defining a front surface, a peripheral side surface extending from the front surface and at least partially surrounded by the wall of the housing, and a notch that, together with a portion of the wall of the housing, defines an acoustic port of the portable electronic device. The electronic device may further include an acoustic port cover positioned at least partially in the acoustic port and a speaker at least partially within the housing and configured to direct sound through the acoustic port cover.Type: GrantFiled: September 10, 2021Date of Patent: March 18, 2025Assignee: APPLE INC.Inventors: Ethan R. Stobbe, Cameron Bauer, Samuel J. Pliska, Macey E. Dade, Baris Ozgen, Lee E. Hooton, Benjamin S. Bustle, Jason M. Gillier, Stoyan P. Hristov, Anthony B. Sinclair, Nicholas Merz, Daniel Jarvis, Ian A. Spraggs, Mitchell T. Hoertz, Michael D. Quinones, David A. Pakula, Brandon R Collins-Smoot, Matthew R. McGuire, Richard H. Koch, Simon C. Helmore, Gareth L. Rose, Marwan Rammah, Zachary S. Scott, Jonathan M. Lee, Melissa A. Wah, Jacob Barton, Laura M. Burke, Jesse P. Harris, Samruddhi A. Deshpande, Ekaterina Pease, David J. Dunsmoor, Nawaf Al-Baghly
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Publication number: 20090117607Abstract: Methods are provided for detecting levels of low oxygen in a tissue of a mammalian subject by administering non-polar halogen compounds to the mammalian subject. Detection may be accomplished using imaging methods involving fluorescence immunohistochemical imaging of the halogen compound.Type: ApplicationFiled: October 31, 2008Publication date: May 7, 2009Inventor: Cameron J. Koch
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Patent number: 7432295Abstract: Novel 18F-fluorine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing the methods of claimed invention are also provided.Type: GrantFiled: February 28, 2006Date of Patent: October 7, 2008Assignee: The Trustees of The University of PennsylvaniaInventors: William R Dolbier, An-Rong Li, Cameron J Koch, Alexander V Kachur
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Patent number: 7230115Abstract: Novel 18F-flourine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia, and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing the methods of claimed invention are also provided.Type: GrantFiled: April 20, 2000Date of Patent: June 12, 2007Assignee: The Trustees of the University of PennsylvaniaInventors: William R Dolbier, An-Rong Li, Cameron J Koch, Alexander V Kachur
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Patent number: 6855828Abstract: Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.Type: GrantFiled: August 25, 2000Date of Patent: February 15, 2005Assignee: The Trustees of the University of PennsylvaniaInventors: Cameron J. Koch, Alexander V. Kachur, Sydney M. Evans, Chyng-Yann Shiue, Ian R. Baird, Kirsten A. Skov, William R. Dolbier, Jr., An-Rong Li, Brian R. James
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Patent number: 6300136Abstract: The invention relates to the discovery that the concentration of free cysteine in mammalian tumor tissue is elevated compared with the concentration of free cysteine in non-tumor tissue of the same origin. Elevated levels of free cysteine is, in turn, correlated with resistance of tumors to antitumor therapy such as chemotherapy and radiation therapy. Therefore, the invention further relates to methods of detecting the presence of tumors in mammalian tissues, assessing the resistance of tumors to antitumor therapies as it relates to free cysteine concentration, and to the identification of compounds which affect free cysteine concentration in mammalian tissues.Type: GrantFiled: September 3, 1998Date of Patent: October 9, 2001Assignee: The Trustees of the University of PennsylvaniaInventors: Cameron J. Koch, Sydney M. Evans
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Patent number: 6252087Abstract: Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.Type: GrantFiled: July 28, 1998Date of Patent: June 26, 2001Assignee: The Trustees of the University of PennsylvaniaInventors: Cameron J. Koch, Alexander V. Kachur, Sydney M. Evans, Chyng-Yann Shiue, Ian R. Baird, Kirsten A. Skov, William R. Dolbier, Jr., An-Rong Li, Brian R. James
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Patent number: 5843404Abstract: Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.Type: GrantFiled: February 8, 1996Date of Patent: December 1, 1998Assignees: Trustees of the University of Pennsylvania, Trustees of the University of RochesterInventors: Cameron J. Koch, Edith M. Lord
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Patent number: 5618679Abstract: Monoclonal antibodies and a method capable of detecting Bowman Birk inhibitor metabolites in a sample of body fluid or tissue are provided.Type: GrantFiled: December 19, 1994Date of Patent: April 8, 1997Assignees: Trustees of the University of Pennsylvania, University of RochesterInventors: Ann R. Kennedy, Cameron J. Koch, Edith M. Lord, Xingsheng Wan
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Patent number: 5616492Abstract: Monoclonal antibodies and a method capable of detecting BBI metabolites in a sample of body fluid or tissue are provided.Type: GrantFiled: June 2, 1995Date of Patent: April 1, 1997Assignees: Trustees of the University of Pennsylvania, University of RochesterInventors: Ann R. Kennedy, Cameron J. Koch, Edith M. Lord, Xingsheng Wan
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Patent number: 5540908Abstract: Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.Type: GrantFiled: August 4, 1994Date of Patent: July 30, 1996Assignees: The Trustees of the Univ. of Pennsylvania, The University of RochesterInventors: Cameron J. Koch, Edith M. Lord
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Patent number: 5223123Abstract: The cathode sub-assembly of a polarographic sensor comprises an elongate housing with a longitudinal opening therethrough and with noble metal wires extending completely through the opening, the wires held symmetrically in the longitudinal opening by an extensive plug of glass which is solidified in situ in sealing contact with the wires and with the wall of the longitudinal opening. A suitable tubular anode is provided through which the cathode sub-assembly protrudes, and a flexible membrane of an inert material, which is permeable to gas and impermeable to water vapor and other than gaseous dissolved solutes, is secured in sealed relationship over the anode and the cathode, with a film of electrolyte bathing the anode and the cathode and contained by the membrane.Type: GrantFiled: May 6, 1991Date of Patent: June 29, 1993Inventor: Cameron J. Koch
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Patent number: 5030336Abstract: The cathode sub-assembly of a polarographic sensor comprises an elongate housing with a longitudinal opening therethrough and with noble metal wires extending completely through the opening, the wires held symmetrically in the longitudinal opening by an extensive plug of glass which is solidified in situ in sealing contact with the wires and with the wall of the longitudinal opening. A suitable tubular anode is provided through which the cathode sub-assembly protrudes, and a flexible membrane of an inert material, which is permeable to gas and impermeable to water vapor and other than gaseous dissolved solutes, is secured in sealed relationship over the anode and the cathode, with a film of electrolyte bathing the anode and the cathode and contained by the membrane.Type: GrantFiled: September 5, 1989Date of Patent: July 9, 1991Inventor: Cameron J. Koch