Patents by Inventor Cameron M. L. Clokie
Cameron M. L. Clokie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190117734Abstract: A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor.Type: ApplicationFiled: December 4, 2018Publication date: April 25, 2019Applicant: Induce Biologics Inc.Inventors: Sean A.F. PEEL, Cameron M.L. CLOKIE
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Publication number: 20170340707Abstract: A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor.Type: ApplicationFiled: August 4, 2017Publication date: November 30, 2017Applicant: Induce Biologics Inc.Inventors: Sean A.F. PEEL, Cameron M.L. CLOKIE
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Publication number: 20170266259Abstract: A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor.Type: ApplicationFiled: June 7, 2017Publication date: September 21, 2017Applicant: Induce Biologics IncInventors: Cameron M. L. CLOKIE, Sean A.F. PEEL
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Patent number: 9724389Abstract: A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor.Type: GrantFiled: October 8, 2014Date of Patent: August 8, 2017Assignee: INDUCE BIOLOGICS, INC.Inventors: Sean A. F. Peel, Cameron M. L. Clokie
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Patent number: 9675670Abstract: A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor.Type: GrantFiled: April 11, 2012Date of Patent: June 13, 2017Assignee: Induce Biologics Inc.Inventors: Cameron M. L. Clokie, Sean A. F. Peel
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Publication number: 20150196620Abstract: A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor.Type: ApplicationFiled: October 8, 2014Publication date: July 16, 2015Inventors: Sean A. F. Peel, Cameron M. L. Clokie
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Publication number: 20140100161Abstract: A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor.Type: ApplicationFiled: April 11, 2012Publication date: April 10, 2014Applicant: Induce Biologics Inc.Inventors: Cameron M.L. Clokie, Sean A.F. Peel
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Patent number: 8329429Abstract: The present invention provides a method of enhanced protein production that comprises the step of expressing a recombinant gene encoding the protein in eukaryotic cells under conditions in which cleavage of the pro-domain of the protein is inhibited or eliminated. Generally the method of the present invention includes the step of inhibiting or altering the cleavage of a pro-domain of a recombinant protein of interest in order to increase the amount of recombinant protein secreted from a eukaryotic cell. Recombinant proteins that can be prepared using the method of this invention include members of the transforming growth factor-? (TGF-?) superfamily, such as bone morphogenetic proteins. Also provided are genetically engineered cells and polynucleotides for performing the method of the invention.Type: GrantFiled: November 25, 2009Date of Patent: December 11, 2012Assignee: Induce Biologics Inc.Inventors: Sean A. F. Peel, Cameron M. L. Clokie, Jeffrey D. Turner
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Publication number: 20110182911Abstract: A method of retaining growth factors on a substrate for release at a treatment region comprises immobilizing an antagonist of the growth factor on a substrate and binding of the growth factor to the antagonist. In one aspect, the substrate is provided on a bioimplant. The resulting bioimplant allows for activity of the growth factor to continue at the region of implantation. According to the method of the invention, exogenous growth factors can be used to stimulate the repair of various tissues and organs at the site requiring repair, and be protected from inactivation, sequestration or degradation. The invention also provides bioimplants and methods of delivering growth factors.Type: ApplicationFiled: January 3, 2011Publication date: July 28, 2011Applicant: INDUCE BIOLOGICS INC.Inventors: Cameron M. L. CLOKIE, Sean A. F. PEEL
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Publication number: 20110172671Abstract: A orthopedic/spine bone mill comprising a vessel and a rotatable grinding tool to produce ground autologous and or allograft bone particles for surgical bone reconstruction use, wherein the vessel includes a wall defining a circular cylindrical chamber having a concentric axis. The vessel further includes generally concave or a cup shaped bottom wall which corresponds to the shape of the cutting blade and a lid adapted to be removably connected to the vessel. The lid includes an opening coincident with the axis. The grinding tool includes an elongated shaft extending through the opening in the Jid along the axis with a cutting blade mounted to the shaft within the chamber whereby the cutting blade can be rotated by motive device, such as a drill find in the operating room, engaging the shaft exterior of the vessel to cut bone, placed in the vessel, into said bone particles.Type: ApplicationFiled: October 9, 2009Publication date: July 14, 2011Inventors: Michael Mcmillan, Ariel Dujovne, Marc-Andre Thebault, Cameron M.L. Clokie
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Publication number: 20100087625Abstract: The present invention provides a method of enhanced protein production that comprises the step of expressing a recombinant gene encoding the protein in eukaryotic cells under conditions in which cleavage of the pro-domain of the protein is inhibited or eliminated. Generally the method of the present invention includes the step of inhibiting or altering the cleavage of a pro-domain of a recombinant protein of interest in order to increase the amount of recombinant protein secreted from a eukaryotic cell. Recombinant proteins that can be prepared using the method of this invention include members of the transforming growth factor-? (TGF-?) superfamily, such as bone morphogenetic proteins. Also provided are genetically engineered cells and polynucleotides for performing the method of the invention.Type: ApplicationFiled: November 25, 2009Publication date: April 8, 2010Inventors: Sean A.F. PEEL, Cameron M.L. CLOKIE, Jeffrey D. TURNER
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Publication number: 20090143830Abstract: The invention concerns a novel moldable and/or flowable composition for application to a bone defect site to promote new bone growth at the site. The composition includes a therapeutic material and a carrier comprising means for achieving reverse phase characteristics. In one embodiment, the therapeutic material can be a resorbable alloplastic material and the carrier can be a poloxamer. In a specific embodiment, the resorbable alloplastic material is a biphasic material composed of hydroxyapatite and tricalcium phosphate (HA-TCP), and the carrier is poloxamer 407 (Pluronic® F127). The invention further includes methods for using the novel composition.Type: ApplicationFiled: September 23, 2008Publication date: June 4, 2009Inventors: Nicolas Bourgeois, Cameron M.L. Clokie, Uwe Tritthardt, Michael McMillan
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Publication number: 20040022858Abstract: A biocompatible connective tissue repair composition which comprises a therapeutic material and a carrier comprising a means for achieving reverse phase characteristics, and methods for using said composition. The therapeutic material can be demineralized bone powder, and the carrier can be a poloxamer such as poloxamer 407.Type: ApplicationFiled: July 28, 2003Publication date: February 5, 2004Applicant: GenSci OrthoBiologics, Inc.Inventor: Cameron M.L. Clokie
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Patent number: 6623748Abstract: A biocompatible connective tissue repair composition which comprises a therapeutic material and a carrier comprising a means for achieving reverse phase characteristics, and methods for using said composition. The therapeutic material can be demineralized bone powder, and the carrier can be a poloxamer such as poloxamer 407.Type: GrantFiled: August 27, 2001Date of Patent: September 23, 2003Assignee: Gensci OrthoBiologics, Inc.Inventor: Cameron M. L. Clokie
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Publication number: 20020034531Abstract: A biocompatible connective tissue repair composition which comprises a therapeutic material and a carrier comprising a means for achieving reverse phase characteristics, and methods for using said composition. The therapeutic material can be demineralized bone powder, and the carrier can be a poloxamer such as poloxamer 407.Type: ApplicationFiled: August 27, 2001Publication date: March 21, 2002Applicant: GenSci OrthoBiologics, Inc.Inventor: Cameron M.L. Clokie
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Patent number: 6309659Abstract: A biocompatible connective tissue repair composition which comprises a therapeutic material and a carrier comprising a means for achieving reverse phase characteristics, and methods for using said composition. The therapeutic material can be demineralized bone powder, and the carrier can be a poloxamer such as poloxamer 407.Type: GrantFiled: September 2, 1997Date of Patent: October 30, 2001Assignee: GenSci OrthoBiologics, Inc.Inventor: Cameron M. L. Clokie
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Patent number: 6287312Abstract: A bone mill comprising a vessel and a rotatable grinding tool to produce ground autologous bone particles for surgical bone reconstruction use, wherein the vessel includes a wall defining a circular cylindrical chamber having a concentric axis. The vessel further includes a bottom wall at right angle to the axis and a lid adapted to be removably connected to the vessel. The lid includes an opening coincident with the axis. The grinding tool includes an elongated shaft extending through the opening in the lid along the axis with a cutting blade mounted to the shaft within the chamber whereby the cutting blade can be rotated by motive device, such as a dental drill, engaging the shaft exterior of the vessel to cut bone, placed in the vessel, into said bone particles.Type: GrantFiled: March 9, 2000Date of Patent: September 11, 2001Inventors: Cameron M. L. Clokie, Ariel R. Dujovne
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Patent number: 5503558Abstract: A liquid composition comprising a transforming growth factor .beta. (TGF-.beta.) in a liquid carrier which gels at about 37.degree. C., promotes osseointegration of an implant in bone, when introduced into a bore in the bone, prior to insertion of the implant in the bone; a method of placing an implant in bone comprises injecting said liquid composition into a bore in the bone prior to insertion of the implant in the bore, the TGF-.beta. being present in the liquid composition in a concentration effective in an interspace between an inner surface of the bore and an outer surface of the implant, to promote osseointegration.Type: GrantFiled: November 12, 1993Date of Patent: April 2, 1996Assignee: McGill UniversityInventor: Cameron M. L. Clokie