Patents by Inventor Cameron M. Smith

Cameron M. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PURIFICATION OF MESSENGER RNA
    Publication number: 20230062449
    Abstract: The present invention provides, among other things, methods for purifying high quality messenger RNA (mRNA) suitable for clinical use, without using any caustic or flammable solvents. The present invention is, in part, based on surprising discovery that mRNA can be successfully purified by selective precipitation and washing without using ethanol while maintaining integrity and high purity of mRNA. Thus, the present invention provides an effective, reliable, and safer method of purifying RNA from large scale manufacturing process therapeutic applications without using any caustic or inflammable solvents.
    Type: Application
    Filed: July 22, 2022
    Publication date: March 2, 2023
    Inventors: Jonathan Abysalh, Frank DeRosa, Cameron M. Smith, Jorel E. Vargas
  • Methods for purification of messenger RNA
    Patent number: 11453877
    Abstract: The present invention provides, among other things, methods for purifying high quality messenger RNA (mRNA) suitable for clinical use, without using any caustic or flammable solvents. The present invention is, in part, based on surprising discovery that mRNA can be successfully purified by selective precipitation and washing without using ethanol while maintaining integrity and high purity of mRNA. Thus, the present invention provides an effective, reliable, and safer method of purifying RNA from large scale manufacturing process therapeutic applications without using any caustic or inflammable solvents.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: September 27, 2022
    Assignee: Translate Bio, Inc.
    Inventors: Jonathan Abysalh, Frank DeRosa, Jorel E. Vargas, Cameron M. Smith
  • METHODS AND COMPOSITIONS FOR MESSENGER RNA PURIFICATION
    Publication number: 20210324369
    Abstract: The present invention provides, among other things, methods for purifying high quality messenger (mRNA) suitable for clinical use. The present invention is, in part, based on surprising discovery that capping and tailing mRNA in reaction buffer having a pH lower than 8.0 and MgCl2 at a concentration of less than 1.25 mM can increase RNA integrity of final mRNA product. Thus, the present invention provides an effective, reliable, and efficient method of manufacturing high quality RNA at large scale for therapeutic use.
    Type: Application
    Filed: February 10, 2021
    Publication date: October 21, 2021
    Inventors: Jonathan Abysalh, Jorel Vargas, Cameron M. Smith, Joseph Parrella, Frank DeRosa
  • METHODS FOR PURIFICATION OF MESSENGER RNA
    Publication number: 20210002635
    Abstract: The present invention provides, among other things, methods for purifying high quality messenger RNA (mRNA) suitable for clinical use, without using any caustic or flammable solvents. The present invention is, in part, based on surprising discovery that mRNA can be successfully purified by selective precipitation and washing without using ethanol while maintaining integrity and high purity of mRNA. Thus, the present invention provides an effective, reliable, and safer method of purifying RNA from large scale manufacturing process therapeutic applications without using any caustic or inflammable solvents.
    Type: Application
    Filed: May 15, 2020
    Publication date: January 7, 2021
    Inventors: Jonathan Abysalh, Frank DeRosa, Jorel Vargas, Cameron M. Smith