Abstract: A cutting guide assembly (5) for assisting the modification of a work piece (142) by a cutting tool (47) includes a support surface (125) for receiving and supporting a work piece (142); a guide member (110) including a guide edge (108) for guiding the cutting tool (47); an adjustable stop member (106) configured for abutment with the work piece (142) to locate the work piece (142) in a cutting position relative to the guide edge (108). A selected portion of the work piece (142) is aligned with the guide edge (108). At least one clamp (160) is arranged to clamp the work piece (142) in said cutting position. The guide member (110) is fixed in position and the adjustable stop member (106) is movable relative to the guide member (110) to selectively locate the work piece (142) in a plurality of cutting positions relative to the guide edge (108).

Abstract: The present invention provides methods for stabilizing pluripotent cells through the transcriptional activation of c-myc. Alternatively, the cells are stabilized through the transcriptional activation of c-myc, and the stabilization of c-myc protein levels. c-myc protein can be stabilized through the inhibition of GSK3? or through other components of the cellular machinery that impact on c-myc stability. The invention contemplates the stabilized pluripotent cells produced using the methods described herein. Methods for the identification of compounds that modulate the stabilization of pluripotent cells through modulating transcriptional activation of c-myc, stabilization of c-myc protein levels, and/or inhibition of GSK3? activity are also contemplated.