Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. The filters may include at least one active layer disposed on a porous substrate. The at least one active layer may include intrinsic and/or intentional formed pores. In some embodiments, the flow resistance of the porous substrate may be selected to limit flow through defects and intrinsic pores in the at least one active layer.

Abstract: The present disclosure relates to methods of treating or preventing a viral infection in a subject. More specifically, the invention relates to methods of treating or preventing a Mononegavirales viral infection in a subject that comprises administering an effective amount of an angiotensin II signalling inhibitor.

Abstract: The present invention relates to methods of modulating an immune response and/or cytokine production in a subject, the method comprises administering to the subject a compound which modifies C6orf106 protein activity. The present invention also relates to compounds for modifying C6orf106 protein activity in a subject, as well as to screening methods for identifying such compounds.

Abstract: The present invention relates to methods of detecting an increased likelihood of virus infection in a subject. In particular, the present invention relates to methods of detecting an increased likelihood of virus infection in a subject by detecting an altered level of at least one microRNA (miRNA), as well as methods of treating or preventing virus infection. The present invention also relates to nucleotide arrays, oligonucleotides and kits useful for the detection of miRNAs associated with an increased likelihood of virus infection in a subject.

Abstract: The present invention relates to methods of detecting an increased likelihood of virus infection in a subject. In particular, the present invention relates to methods of detecting an increased likelihood of virus infection in a subject by detecting an altered level of at least one microRNA (miRNA), as well as methods of treating or preventing virus infection. The present invention also relates to nucleotide arrays, oligonucleotides and kits useful for the detection of miRNAs associated with an increased likelihood of virus infection in a subject.

Abstract: The present invention relates to methods of detecting an increased likelihood of virus infection in a subject. In particular, the present invention relates to methods of detecting an increased likelihood of virus infection in a subject by detecting an altered level of at least one microRNA (miRNA), as well as methods of treating or preventing virus infection. The present invention also relates to nucleotide arrays, oligonucleotides and kits useful for the detection of miRNAs associated with an increased likelihood of virus infection in a subject.

Abstract: The present invention comprises a loudspeaker system that includes a loudspeaker and a detachable mount. In one or more embodiments, the loudspeaker and mount include electrical connectors that are engaged when the loudspeaker is attached to the mount. In one or more embodiments, the loudspeaker and mount comprise mating mounting structures that support the loudspeaker on the mount when the mounting structure of the loudspeaker is engaged with the mounting structure of the mount. In one or more embodiments, mating electrical connectors are incorporated in the mounting structures such that engaging the mounting structures simultaneously engages the electrical connectors. In one or more embodiments, the loudspeaker comprises a locking mechanism that positively retains the loudspeaker on the mount.

Abstract: A ceiling speaker assembly is disclosed. In one or more embodiments, the ceiling speaker assembly includes a three-dimensional support frame attached to a perforated grille. The support frame is configured with a speaker aperture adjacent to which a speaker is mounted and a port aperture. The speaker aperture and port aperture are configured such that the speaker aperture is in communication with the front of the speaker and the port aperture is in communication with the rear of the speaker. In one or more embodiments, the support frame includes a horn cavity that functions as an acoustical cross-over such that higher frequencies generated by the speaker are emitted primarily through the speaker aperture and the lower frequencies generated by the speaker are emitted primarily through the port aperture.

Abstract: The present invention comprises a method and apparatus for installing a tile-mounted ceiling speaker that combines the ease of installation of a lay-in speaker system with the visual appearance of a tile-mounted speaker system. In one or more embodiments, the apparatus of the present invention includes a support frame and back box assembly configured for installation on top of a ceiling tile and a loudspeaker cartridge configured to be mounted to the support frame through an appropriately-sized hole in the ceiling tile.

Abstract: A ceiling speaker assembly is disclosed. In one or more embodiments, the ceiling speaker assembly includes a three-dimensional support frame attached to a perforated grille. The support frame is configured with a speaker aperture adjacent to which a speaker is mounted and a port aperture. The speaker aperture and port aperture are configured such that the speaker aperture is in communication with the front of the speaker and the port aperture is in communication with the rear of the speaker. In one or more embodiments, the support frame includes a horn cavity that functions as an acoustical cross-over such that higher frequencies generated by the speaker are emitted primarily through the speaker aperture and the lower frequencies generated by the speaker are emitted primarily through the port aperture.

Abstract: A method and apparatus for providing a loudspeaker assembly is provided. In accordance with at least one embodiment, apparatus is provided comprising a ground plane, a loudspeaker driver mounted in a loudspeaker driver aperture of the ground plane, and a grille positioned relative to the ground plane such that a distance between the grille and the ground plane decreases with increasing distance from the loudspeaker driver. The loudspeaker assembly can be used to replace ceiling tiles having any size or configuration, and can also me mounted in other surfaces, such as ceiling walls, floors, table tops, etc. made of drywall, hard decking, wood, stone, cement, glass, or any other material or type of construction, or configured in a stand-alone loudspeaker frame or cabinet. The loudspeaker assembly of the present invention can be mounted in any orientation.

Abstract: The present invention comprises a tile-mounted ceiling speaker that combines the ease of installation of a lay-in speaker system with the visual appearance of a tile-mounted speaker system. In one or more embodiments, the apparatus of the present invention includes a support frame and back box assembly configured for installation on top of a ceiling tile and a loudspeaker cartridge configured to be mounted to the support frame through an appropriately-sized hole in the ceiling tile. In one or more embodiments, the invention comprises a peripheral flange and a plurality of flip dogs for mounting the cartridge to the support frame that are configured to be disposed in the interior of the back box when engaged.

Abstract: A ceiling speaker assembly is disclosed. In one or more embodiments, the ceiling speaker assembly includes a three-dimensional support frame attached to a perforated grille. The support frame is configured with a speaker aperture adjacent to which a speaker is mounted and a port aperture. The speaker aperture and port aperture are configured such that the speaker aperture is in communication with the front of the speaker and the port aperture is in communication with the rear of the speaker. In one or more embodiments, the support frame includes a horn cavity that functions as an acoustical cross-over such that higher frequencies generated by the speaker are emitted primarily through the speaker aperture and the lower frequencies generated by the speaker are emitted primarily through the port aperture.

Abstract: A loudspeaker assembly is provided. In one or more embodiments the loudspeaker assembly comprises a perforated grille, a three dimensional loudspeaker frame to which a speaker driver is mounted, and a rear baffle. In one or more embodiments, the loudspeaker frame and rear baffle define a controlled volume around the speaker driver. In one or more embodiments the controlled volume comprises a driver cavity and a horn cavity in communication with the driver cavity and a port aperture.

Abstract: The present invention comprises a tile-mounted ceiling speaker that combines the ease of installation of a lay-in speaker system with the visual appearance of a tile-mounted speaker system. In one or more embodiments, the apparatus of the present invention includes a support frame and back box assembly configured for installation on top of a ceiling tile and a loudspeaker cartridge configured to be mounted to the support frame through an appropriately-sized hole in the ceiling tile. In one or more embodiments, the invention comprises a peripheral flange and a plurality of flip dogs for mounting the cartridge to the support frame that are configured to be disposed in the interior of the back box when engaged.

Abstract: The present invention comprises a loudspeaker system that includes a loudspeaker and a detachable mount. In one or more embodiments, the loudspeaker and mount include electrical connectors that are engaged when the loudspeaker is attached to the mount. In one or more embodiments, the loudspeaker and mount comprise mating mounting structures that support the loudspeaker on the mount when the mounting structure of the loudspeaker is engaged with the mounting structure of the mount. In one or more embodiments, mating electrical connectors are incorporated in the mounting structures such that engaging the mounting structures simultaneously engages the electrical connectors. In one or more embodiments, the loudspeaker comprises a locking mechanism that positively retains the loudspeaker on the mount.

Abstract: A method and apparatus for providing a loudspeaker assembly is provided. In accordance with at least one embodiment, a method is provided which comprises forming a loudspeaker frame so as to define a driver housing portion, a horn portion, and a conformal portion. A driver aperture is defined for the driver housing portion, and a port aperture is defined for the horn portion. A driver is attached to the loudspeaker frame proximate to the driver aperture. A rear baffle is applied to a first conformal portion surface of the conformal portion of the loudspeaker frame. The rear baffle defines a horn cavity wall of a horn cavity of the horn portion. The horn cavity has an increasing cross sectional area as the distance from the driver housing portion increases. A grille is applied to a second conformal portion surface of the conformal portion of the loudspeaker frame.

Abstract: The present invention comprises a method and apparatus for installing a tile-mounted ceiling speaker that combines the ease of installation of a lay-in speaker system with the visual appearance of a tile-mounted speaker system. In one or more embodiments, the apparatus of the present invention includes a support frame and back box assembly configured for installation on top of a ceiling tile and a loudspeaker cartridge configured to be mounted to the support frame through an appropriately-sized hole in the ceiling tile.

Abstract: A loudspeaker assembly is provided. In one or more embodiments the loudspeaker assembly comprises a perforated grille, a three dimensional loudspeaker frame to which a speaker driver is mounted, and a rear baffle. In one or more embodiments, the loudspeaker frame and rear baffle define a controlled volume around the speaker driver. In one or more embodiments the controlled volume comprises a driver cavity and a horn cavity in communication with the driver cavity and a port aperture.

Abstract: A method and apparatus for providing a loudspeaker assembly is provided. In accordance with at least one embodiment, apparatus is provided comprising a ground plane, a loudspeaker driver mounted in a loudspeaker driver aperture of the ground plane, and a grille positioned relative to the ground plane such that a distance between the grille and the ground plane decreases with increasing distance from the loudspeaker driver. The loudspeaker assembly can be used to replace ceiling tiles having any size or configuration, and can also me mounted in other surfaces, such as ceiling walls, floors, table tops, etc. made of drywall, hard decking, wood, stone, cement, glass, or any other material or type of construction, or configured in a stand-alone loudspeaker frame or cabinet. The loudspeaker assembly of the present invention can be mounted in any orientation.