Patents by Inventor Camille Georges Wermuth

Camille Georges Wermuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of the interaction between MDM2 and P53
    Patent number: 8404683
    Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q and Z have defined meanings.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: March 26, 2013
    Assignee: Janssen Pharmaceutical N.V.
    Inventors: Jean Ferand Armand Lacrampe, Christophe Meyer, Yannick Aimè Eddy Ligny, Imre Christian Francis Csoka, Luc Van Hijfte, Janine Arts, Bruno Schoentjes, Camille Georges Wermuth, Bruno Giethlen, Jean-Marie Contreras, Muriel Joubert
  • Cyclic-alkylamine derivatives as inhibitors of the interaction between MDM2 and P53
    Patent number: 8377961
    Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1, R2, R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: February 19, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jean Fernand Armand Lacrampe, Christophe Meyer, Bruno Schoentjes, Alain Philippe Poncelet, Camille Georges Wermuth, Bruno Giethlen, Jean-Marie Contreras, Muriel Joubert, Luc Van Hijfte
  • CYCLIC-ALKYLAMINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53
    Publication number: 20120071508
    Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1, R2, R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.
    Type: Application
    Filed: November 30, 2011
    Publication date: March 22, 2012
    Inventors: Jean Fernand Armand Lacrampe, Christophe Meyer, Bruno Schoentjes, Alain Philippe Poncelet, Camille Georges Wermuth, Bruno Giethlen, Jean-Marie Contreras, Muriel Joubert, Luc Van Hijfte
  • Cyclic-alkylamine derivatives as inhibitors of the interaction between MDM2 and p53
    Patent number: 8088795
    Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1, R2, R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: January 3, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jean Fernand Armand Lacrampe, Christophe Meyer, Bruno Schoentjes, Alain Philippe Poncelet, Camille Georges Wermuth, Bruno Giethlen, Jean-Marie Contreras, Muriel Joubert, Luc Van Hijfte
  • 6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof
    Patent number: 8063061
    Abstract: The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and therapeutic use thereof.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: November 22, 2011
    Assignee: Sanofi-Aventis
    Inventors: Yvette Muneaux, Samir Jegham, Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Deroco, Camille-Georges Wermuth
  • STYRLYQUINOLINES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC USES
    Publication number: 20110224242
    Abstract: The present disclosure concerns new substituted styrylquinolines, the process of their preparation and their therapeutic uses as integrase inhibitors and/or for the treatment and/or prevention of HIV.
    Type: Application
    Filed: July 23, 2009
    Publication date: September 15, 2011
    Applicant: BIOALLIANCE PHARMA
    Inventors: Bruno Giethlen, Mathieu Michaut, Claude Monneret, Emilienne Soma, Laurent Thibault, Camille Georges Wermuth
  • Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics
    Patent number: 8012991
    Abstract: The present disclosure relates to pyridoindolone derivatives of general formula (I): to processes for preparing the same and to their use in therapeutics.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: September 6, 2011
    Assignee: Sanofi-Aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Derocq, Samir Jegham, Yvette Muneaux, Camille-Georges Wermuth
  • Inhibitors of the Interaction Between MDM2 and P53
    Publication number: 20110053937
    Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q and Z have defined meanings.
    Type: Application
    Filed: November 3, 2010
    Publication date: March 3, 2011
    Inventors: Jean Fernand Armand Lacrampe, Christophe Meyer, Yannick Aimé Eddy Ligny, Imre Christian Francis Csoka, Luc Van Hijfte, Janine Arts, Bruno Schoentjes, Camille Georges Wermuth, Bruno Giethlen, Jean-Marie Contreras, Muriel Joubert
  • Inhibitors of the interaction between MDM2 and p53
    Patent number: 7834016
    Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q and Z have defined meanings.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: November 16, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jean Fernand Armand Lacrampe, Christophe Meyer, Yannick Aimé Eddy Ligny, Imre Christian Francis Csoka, Luc Van Hijfte, Janine Arts, Bruno Schoentjes, Camille Georges Wermuth, Bruno Giethlen, Jean-Marie Contreras, Muriel Joubert
  • 6-substituted pyridoindolone derivatives, production and therapeutic use thereof
    Patent number: 7812165
    Abstract: Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2, R3, R4, and R5, have the meanings given in the description; pharmaceutical compositions comprising said compounds; and processes for preparing said compounds and methods of use thereof.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: October 12, 2010
    Assignee: sanofi-aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Deroco, Samir Jegham, Yvette Muneaux, Camille-Georges Wermuth
  • CYCLIC-ALKYLAMINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53
    Publication number: 20100168163
    Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1, R2, R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.
    Type: Application
    Filed: March 19, 2007
    Publication date: July 1, 2010
    Inventors: Jean Fernand Armand Lacrampe, Christophe Meyer, Bruno Schoentjes, Alain Philippe Poncelet, Camille Georges Wermuth, Bruno Giethlen, Jean-Marie Contreras, Muriel Joubert, Luc Van Hijfte
  • Piperidin-2, 6-dione pamoate salts and their use for the treatment of affective disorders
    Publication number: 20090182012
    Abstract: Novel pamoate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-diones and pharmacologically acceptable solvates thereof are devoid of the weight loss and hepatocyte changes in the rat which limited to marginally effective levels the permitted clinical doses of the corresponding hydrochlorides in the treatment or prophylaxis of stress-related affective disorders such as anxiety, depression, migraine and sleep apnoea. The preferred pamoate salts are 3(3,5-dimethoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione pamoate and, especially, 3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione pamoate.
    Type: Application
    Filed: March 18, 2009
    Publication date: July 16, 2009
    Applicant: Prestwick Pharmaceuticals, Inc.
    Inventor: Camille Georges Wermuth
  • Piperidin-2,6-dione pamoate salts and their use for the treatment of stress-related affective disorders
    Patent number: 7514454
    Abstract: Novel pamoate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-diones and pharmacologically acceptable solvates thereof are devoid of the weight loss and hepatocyte changes in the rat which limited to marginally effective levels the permitted clinical doses of the corresponding hydrochlorides in the treatment or prophylaxis of stress-related affective disorders such as anxiety, depression, migraine and sleep apnoea. The preferred pamoate salts are 3(3,5-dimethoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione pamoate and, especially, 3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione pamoate.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: April 7, 2009
    Assignee: Prestwick Pharmaceuticals, Inc.
    Inventor: Camille Georges Wermuth
  • Derivatives of glycinergic R(+)-2-amino-3-hydroxypropanoic acid
    Patent number: 7488755
    Abstract: The use of R(+)-2-amino-3-hydroxypropanoic acid derivatives, nitrogen substituted by a (C1-C6)alkyl, (C3-C6)alkenyl, 3-oxo(C5-C6)alkyl, 3-oxo(C4-C6)alken-2-yl, phenyl(C1-C6)alkyl, phenyl(C2-C6)alkenyl, gem-diphenyl(C1-C6)alkyl, gem-diphenyl(C2-C6)alkenyl, (C1-C6)alcanoyl, optionally N-substituted alanyl, optionally N,N?-disubstituted lysinoyl, phenyl(C1-C6)alkylydene or gem-diphenyl(C1-C6)alkylidene group, and of the pharmaceutically acceptable salts thereof, for preparation of medicaments intended for the treatment of CNS diseases due to reduced glycinergic transmission, particularly for the treatment of autism, schizophrenia and Alzheimer's disease, is described.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: February 10, 2009
    Assignee: Prestwick Pharmaceuticals, Inc.
    Inventors: Kathleen Clarence-Smith, Jean-Marie Georges Contreras, Laurence Nathalie Deyon, Camille Georges Wermuth
  • 6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof
    Publication number: 20080262020
    Abstract: The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and therapeutic use thereof.
    Type: Application
    Filed: April 9, 2008
    Publication date: October 23, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Yvette MUNEAUX, Samir JEGHAM, Bernard BOURRIE, Pierre CASELLAS, Paola CIAPETTI, Jean-Marie DEROCQ, Camille-Georges WERMUTH
  • Pyridoindolone Derivatives Substituted in the 3-Position by a Phenyl, Their Preparation and Their Application in Therapeutics
    Publication number: 20080214538
    Abstract: The present disclosure relates to pyridoindolone derivatives of general formula (I): to processes for preparing the same and to their use in therapeutics.
    Type: Application
    Filed: May 12, 2008
    Publication date: September 4, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Derocq, Samir Jegham, Yvette Muneaux, Camille-Georges Wermuth
  • Novel Pyrrolodihydroisoquinolines as Pde 10 Inhibitors
    Publication number: 20080161338
    Abstract: The invention relates to novel pyrrolodihydroisoquinoline derivatives, which are efficacious inhibitors of PDE10.
    Type: Application
    Filed: January 11, 2006
    Publication date: July 3, 2008
    Applicant: ALTANA PHARMA AG
    Inventors: Matthias Vennemann, Thomas Bar, Jurgen Braunger, Paola Ciapetti, Jean-Marie Contreras, Camille George Wermuth
  • Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics
    Patent number: 7390818
    Abstract: The present invention relates to pyridoindolone derivatives substituted in the 3-position by a phenyl of general formula (I): to processes for preparing the same and to their use in therapeutics.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: June 24, 2008
    Assignee: Sanofi-Aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Derocq, Samir Jegham, Yvette Muneaux, Camille-Georges Wermuth
  • Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol and applications thereof
    Patent number: 7354918
    Abstract: The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical —AR? wherein A represents a heteroatom and R? represents a group selected from the group comprising linear or branched C1-C6 alkyl radicals, C2-C6 alkenyls, C2-C6 alkynyls, arylalkyls; esters comprising the formula —R1— CO—O—R2; amides comprising the formula —R3—CO—NZY, wherein Y and Z together can form a cycloalkyl radical or a heterocyclic radical, optionally substituted by one or more alkyl radicals; a radical selected from the group comprising alkyl radicals, alkenyls or alkynyls, substituted by at least one amine with formula —NZY; or one of the pharmaceutically-acceptable salts thereof, including the isomers, enantiomers and diastereoisomers thereof and mixtures thereof.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: April 8, 2008
    Assignee: Biocortech
    Inventors: Paola Ciapetti, Laurence Deyon, Camille-Georges Wermuth, Jean-François Pujol, Dinah Weissmann
  • 6-Substituted pyridoindolone derivatives, production and therapeutic use thereof
    Publication number: 20070129365
    Abstract: Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2, R3, R4, and R5, have the meanings given in the description; pharmaceutical compositions comprising said compounds; and processes for preparing said compounds and methods of use thereof.
    Type: Application
    Filed: October 18, 2006
    Publication date: June 7, 2007
    Applicant: sanofi-aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Deroco, Samir Jegham, Yvette Muneaux, Camille-Georges Wermuth