Abstract: This invention provides methods of treatment for a variety of inflammation pathologies using thione-forming disulfides (TFDs). The treatments are particularly effective in the context of inflammations primarily due to excessive activity of innate immune system components, macrophage activity and inflammation arising from excessive production of IL-1. TFD inhibition of both IL-1 and IL-6 can reduce the detrimental effects of the cytokine storms known to increase morbidity and mortality caused by certain infections, such as COVID-19 viral pneumonia.

Abstract: The invention provides for the methods of modulating an immune response in an individual by administration of a thione-forming disulfide (TFD). Immunomodulatory responses include, but are not limited to, increased natural killer cell activity, expansion of NK cell population, decreased B cell population, decreased antibody production, and increased mitogenic potential. Methods of modulating such immune responses and the uses of immunomodulation are provided herein.

Abstract: A wax-based drawing instrument having a substantially rigid wax-based cap applied to the ends of the fingers of the hand. The instrument has a frustroconical shaped internal cavity to allow the placement on a finger tip. The user can have a different color on each finger, allowing many colors to be used without having to put down one instrument and take up another. Several colors can also be applied simultaneously.

Abstract: The invention provides for the methods of modulating an immune response in an individual by administration of a thione-forming disulfide (TFD). Immunomodulatory responses include, but are not limited to, increased natural killer cell activity, expansion of NK cell population, decreased B cell population, decreased antibody production, and increased mitogenic potential. Methods of modulating such immune responses and the uses of immunomodulation are provided herein.

Abstract: A feeding duct for writing liquid in fountain pen nibs and method of producing same, wherein the duct includes a substantially cylindrical element having multiple circumferential grooves creating respective fins, of a support for a nib and a connecting mans to an ink reservoir the feeding duct is produced in two distinct portions disposed symmetrically in relation to a longitudinal plane each portion is provided with a longitudinal recess extending along the entire length of the portion, apart from the front end thereof, and is combined with recess of the other portion to form a groove when the two portions are secured one to another.