Patents by Inventor Can Cenik

Can Cenik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and Methods for Multi-Scale, Annotation-Independent Detection of Functionally-Diverse Units of Recurrent Genomic Alteration
    Publication number: 20190348151
    Abstract: The functional interpretation of somatic mutations remains a persistent challenge in the interpretation of human genome data. Systems and methods for detecting significantly mutated regions (SMRs) in the human genome permit the discovery and identification of multi-scale cancer-driving mutational hotspot clusters. Systems and methods of SMR detection reveal differentially mutated genetic regions across various cancer types. SMR detection and annotation reveals a diverse spectrum of functional elements in the genome, including at least single amino acids, compete coding exons and protein domains, microRNAs, transcription factor binding sites, splice sites, and untranslated regions. Systems and methods of SMR detection optionally including protein structure mapping uncover recurrent somatic alterations within proteins.
    Type: Application
    Filed: May 28, 2019
    Publication date: November 14, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Carlos L. Araya, Can Cenik, William J. Greenleaf, Jason A. Reuter, Michael P. Snyder
  • Compositions and methods for constructing cDNA libraries that allow for mapping the 5? and 3? ends of RNAs
    Patent number: 9828600
    Abstract: This disclosure provides methods and compositions for preparing and constructing cDNA libraries.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: November 28, 2017
    Assignee: University of Massachusetts
    Inventors: Melissa J. Moore, Erin E. Heyer, Emiliano P. Ricci, Hakan Ozadam, Can Cenik, Xin Li
  • Systems and Methods for Multi-Scale, Annotation-Independent Detection of Functionally-Diverse Units of Recurrent Genomic Alteration
    Publication number: 20160378915
    Abstract: The functional interpretation of somatic mutations remains a persistent challenge in the interpretation of human genome data. Systems and methods for detecting significantly mutated regions (SMRs) in the human genome permit the discovery and identification of multi-scale cancer-driving mutational hotspot clusters. Systems and methods of SMR detection reveal differentially mutated genetic regions across various cancer types. SMR detection and annotation reveals a diverse spectrum of functional elements in the genome, including at least single amino acids, compete coding exons and protein domains, microRNAs, transcription factor binding sites, splice sites, and untranslated regions. Systems and methods of SMR detection optionally including protein structure mapping uncover recurrent somatic alterations within proteins.
    Type: Application
    Filed: March 24, 2016
    Publication date: December 29, 2016
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Carlos L. Araya, Can Cenik, William J. Greenleaf, Jason A. Reuter, Michael P. Snyder
  • Compositions and Methods for Constructing cDNA Libraries that Allow for Mapping the 5' and 3' Ends of RNAs
    Publication number: 20150099671
    Abstract: This disclosure provides methods and compositions for preparing and constructing cDNA libraries.
    Type: Application
    Filed: September 22, 2014
    Publication date: April 9, 2015
    Inventors: Melissa J. Moore, Erin E. Heyer, Emiliano P. Ricci, Hakan Ozadam, Can Cenik, Xin Li