Patents by Inventor Can Ozbal

Can Ozbal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190265211
    Abstract: Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
    Type: Application
    Filed: October 12, 2018
    Publication date: August 29, 2019
    Inventor: Can Ozbal
  • Publication number: 20190234957
    Abstract: Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
    Type: Application
    Filed: August 10, 2018
    Publication date: August 1, 2019
    Inventor: Can Ozbal
  • Publication number: 20180361345
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Application
    Filed: May 14, 2018
    Publication date: December 20, 2018
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Patent number: 10101307
    Abstract: Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: October 16, 2018
    Assignee: PureHoney Technologies, Inc.
    Inventor: Can Ozbal
  • Patent number: 10067140
    Abstract: Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: September 4, 2018
    Assignee: PureHoney Technologies, Inc.
    Inventor: Can Ozbal
  • Patent number: 9968903
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 15, 2018
    Assignee: Life Technologies Corporation
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Publication number: 20170108477
    Abstract: Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
    Type: Application
    Filed: December 28, 2016
    Publication date: April 20, 2017
    Inventor: Can Ozbal
  • Publication number: 20170059580
    Abstract: Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
    Type: Application
    Filed: November 15, 2016
    Publication date: March 2, 2017
    Inventor: Can Ozbal
  • Patent number: 9557317
    Abstract: Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: January 31, 2017
    Assignee: PureHoney Technologies, Inc.
    Inventor: Can Ozbal
  • Publication number: 20160332133
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Application
    Filed: April 18, 2016
    Publication date: November 17, 2016
    Inventors: Robert HESS, John LINTON, Tanya S. KANIGAN, Colin BRENAN, Can OZBAL
  • Patent number: 9494497
    Abstract: Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: November 15, 2016
    Assignee: PureHoney Technologies, Inc.
    Inventor: Can Ozbal
  • Patent number: 9314764
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: April 19, 2016
    Assignee: Life Technologies Corporation
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Publication number: 20150377842
    Abstract: Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 31, 2015
    Inventor: Can Ozbal
  • Publication number: 20150198570
    Abstract: Embodiments of the present disclosure present novel systems, devices and methods for an automated biological sample analysis using mass-spectrometry. The time from sample introduction to the reporting of data, in some embodiments, takes a relatively short amount of time (e.g., several minutes). In some embodiments, a biological sample to be analyzed is a blood sample. For many applications, only a single drop of blood may be sufficient. Through the use of a mixture of standards with unique molecular mass, a quantitative analysis of the target analyte can be performed in a single MS run (for example), eliminating the need to create and analyze standard curves. One advantage of such embodiments may be that the system, devices, and methods can eliminate the need for batch creation since the requirement to amortize the time and effort of creating and analyzing standard curves can be eliminated.
    Type: Application
    Filed: January 9, 2015
    Publication date: July 16, 2015
    Inventor: Can Ozbal
  • Publication number: 20120021951
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Application
    Filed: July 21, 2011
    Publication date: January 26, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Publication number: 20110251104
    Abstract: A method for the quantitative determination of the activity of enzymes in the Sirtuin family through the quantification of the acetyl-ADPr product that is formed is provided. The method described allows for a wide range of substrates, including peptides, intact proteins, or protein complexes (e.g. nucleosomes) to be used as substrates without the need for additional analytical methods to be developed.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 13, 2011
    Inventors: Can Ozbal, William LaMarr
  • Publication number: 20100261159
    Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
    Type: Application
    Filed: August 10, 2006
    Publication date: October 14, 2010
    Inventors: Robert Hess, John Linton, Tanya S. Kanigan, Colin Brenan, Can Ozbal
  • Patent number: 7588725
    Abstract: An auto-injection system provides high throughput screening of fluidic samples. A sample injection valve has a first position which applies a reduced pressure to a sample sipper tube for aspirating a fluidic sample into the sample sipper tube, and a second position which delivers the fluidic sample to a sample supply loop. A column control valve has a first position which delivers the fluidic sample from the sample supply loop to a sample chromatography column, and a second position which reverses direction of fluid flow through the sample chromatography column to deliver the fluidic sample to a sample analyzer. A wash control valve has a first position which supplies a wash buffer solution to the sample chromatography column in a forward fluid flow direction, and a second position which supplies elution solvent to flush the sample supply loop.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: September 15, 2009
    Assignee: BioTrove, Inc.
    Inventors: Can Ozbal, Donald Green
  • Patent number: 7100460
    Abstract: In accordance with an illustrative embodiment of the invention, a system for obtaining a fluidic sample from a container is presented. The container defines a volume for holding the sample, the volume being closed by a seal. An outer tube has a proximal end and a distal end, the proximal end shaped to permit piercing the seal. An inner tube has an end region axially movable within the outer tube between a piercing position, wherein an end of the inner tube in the end region is retracted from the proximal end of the outer tube, and a transmission position, wherein the end of the inner tube extends axially beyond the proximal end of the outer tube. The outer tube and the inner tube form a tube assembly. At least one of the tube assembly and the container can be moved to cause the outer tube to pierce the seal and, after the seal is pierced, the inner tube can be used in the transmission position to permit fluid transfer with respect to the volume.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: September 5, 2006
    Assignee: Biotrove, Inc.
    Inventor: Can Özbal
  • Publication number: 20050223822
    Abstract: In accordance with an illustrative embodiment of the invention, a system for obtaining a fluidic sample from a container is presented. The container defines a volume for holding the sample, the volume being closed by a seal. An outer tube has a proximal end and a distal end, the proximal end shaped to permit piercing the seal. An inner tube has an end region axially movable within the outer tube between a piercing position, wherein an end of the inner tube in the end region is retracted from the proximal end of the outer tube, and a transmission position, wherein the end of the inner tube extends axially beyond the proximal end of the outer tube. The outer tube and the inner tube form a tube assembly. At least one of the tube assembly and the container can be moved to cause the outer tube to pierce the seal and, after the seal is pierced, the inner tube can be used in the transmission position to permit fluid transfer with respect to the volume.
    Type: Application
    Filed: April 8, 2004
    Publication date: October 13, 2005
    Inventor: Can Ozbal