Abstract: Provided herein are Platelet Activating Factor 4 (PF4) polypeptide and other compositions and methods for improving cognitive function in an individual comprising treatment with PF4 and other polypeptides.

Abstract: Provided herein are a pharmaceutical composition for preventing or treating a stress-related disease, which includes the DISC1 protein or a gene encoding the DISC protein, and a method of screening a material for preventing or treating the stress-related disease. As a result of studying the association between DISC1 and psychological stress, the inventors of the present disclosure verified the function of DISC1 in downregulating ER-mitochondria Ca2+ transfer induced by stress hormone-mediated oxidative stress by competitively inhibiting the binding of IP3 to inositol 1,4,5-trisphosphate (IP3) receptor type1 (IP3R1) by binding to the IP3R1 at the MAM, and an acting site of DISC1, and this provides a model of intracellular calcium response to physiological stress, and DISC1, a stress modulating substance, and the model may be usefully used in related fields for the prevention and treatment of stress-related diseases.