Publication number: 20240400984
Abstract: This invention provides the use of one or more inhibitors reducing the expression or activity of the genes, the genes's RNA, or the genes's encoding proteins to treat the diseases associated with neuronal functional loss or the neuronal death. The genes are selected from: Plpp7, Fam126a, Gprc5c, Tmed4, Tle6, Psmd5, Mastl, Ssr3, Rhoa, Rfx8, Rbm10, Hnrupa3, Prpf6, Pou3f3, Ncoal, Ccdc8, Adck1, Gjb2, Smad9, Nr2e1, Atp10b, Nid1, Tmcc3, Rad21, Amigo1, Cep192, Sepp1, Klf12, Nxf1, Trp53inp2, Phlpp1, Ptpdc1, Pebp1, Gm22174, Gm26117, Mir873a, Mir1900, Gm22414, Khdc4, Hnrnpa0, Hnrnph2, Srrm1, Hnrnpf, Srsf4, Mbnl1, Zbtb42, Kcmf1, Gtf2i, Chgb, Fos, Kat2a, Tsg101, Hmgb4, Junb, Cdx2, Cers2, Rhox6, Thap3, Zscan25.
Type:
Application
Filed:
March 13, 2023
Publication date:
December 5, 2024
Inventors:
Haibo Zhou, Canbin Feng, Zhengzheng Xu, Ni Gao, Xinde Hu