Patents by Inventor Candadai S Ramadoss

Candadai S Ramadoss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of insulin by cleavage of a fusion protein and fusion proteins containing insulin A and B chains
    Patent number: 6337194
    Abstract: The invention provides a protein precursor of a double-chain molecule having at least two polypeptide chains linked by two disulfide bonds. The precursor has the general formula B—Z—A wherein B and A are the two insulin polypeptide chains, and Z is a polypeptide comprising at least one site for proteolytic cleavage in a eukaryotic host cell transformed by DNA coding for the protein precursor or in a eukaryotic cell-free system, resulting in a secreted double-chain product consisting of the disulfide-bonded A and B chains in which a portion of the Z polypeptide is retained on the A chain and/or the B chain and can be removed therefrom by enzymatic or chemical agents in vitro. Preferably the B and A polypeptides are, respectively, the B- and A-chains of insulin linked by two disulfide bonds, and the mature insulin molecule is isolatable from the secreted double-chain product.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: January 8, 2002
    Assignees: Vittal Mallya Scientific Research Foundation, the University of Leicester
    Inventors: Christopher Hadfield, Peter A Meacock, Patnam R Krishnaswamy, Kaithamana Shashi, Krisha K Raina, Candadai S Ramadoss