Abstract: Automated blood sampling and infusion systems are disclosed, which include a sampling pump in communication with a blood sample collection apparatus; an infusion pump configured to perform infusion; and a controller. The controller is configured to: control the infusion pump to perform the infusion on a patient during an infusion event, control the sampling pump to draw blood from the patient into the blood sample collection apparatus during a sample collection event following the infusion event, and automatically store in a memory unit a timestamped data of the infusion event and the sample collection event. There may be multiple infusion events and sample collection events.

Abstract: An apparatus and method for collecting a predetermined amount of blood or other fluid using an automated sampling system is provided.

Abstract: An apparatus and method for collecting a predetermined amount of blood or other fluid using an automated sampling system is provided.

Abstract: An apparatus and method for collecting a predetermined amount of blood or other fluid using an automated sampling system is provided.

Abstract: A cartridge for an automated blood sampling system for collecting samples and a method of sampling fluids from a test subject using an automated blood sampling apparatus including a cartridge are disclosed.

Abstract: A method for delivering a fluid to an animal with a drug delivery device without causing contamination to the drug delivery device. The drug delivery device used by the method may comprise a fluid subsystem with a switching device, disposable syringes, fluid reservoirs, disposable tubing, and a catheter. In one embodiment, the method allows a user to deliver multiple drugs to an animal without contaminating the valves that control the flow of fluid.

Abstract: A method for delivering a fluid to an animal with a drug delivery device without causing contamination to the drug delivery device. The drug delivery device used by the method may comprise a fluid subsystem with a switching device, disposable syringes, fluid reservoirs, disposable tubing, and a catheter. In one embodiment, the method allows a user to deliver multiple drugs to an animal without contaminating the valves that control the flow of fluid.

Abstract: A method for delivering a fluid to an animal with a drug delivery device without causing contamination to the drug delivery device. The drug delivery device used by the method may comprise a fluid subsystem with a switching device, disposable syringes, fluid reservoirs, disposable tubing, and a catheter. In one embodiment, the method allows a user to deliver multiple drugs to an animal without contaminating the valves that control the flow of fluid.

Abstract: A cartridge for an automated blood sampling system for collecting samples and a method of sampling fluids from a test subject using an automated blood sampling apparatus including a cartridge are disclosed.

Abstract: A portable sampling or testing device for pharmacokinetics and physiology studies and a method for using the device in conducting tests on stationary or moving animals, or human test subjects, is disclosed. The device includes an apparatus for conducting a test on a freely moving subject, or a device which may be moved by a technician to be positioned over an immobile subject, such as a premature infant or unconscious human subject in an intensive care ward. The device is designed and sized to be mobile. In one embodiment, the device comprises a wheeled cart which may be moved by a human test subject operably connected to it. In another embodiment, the device comprises a wheeled carriage positioned above an animal which wears a sling connected to the device. The device may include an uninterruptible power supply. The method provides for sampling bodily fluids or acquiring physiological readings from the test subject.

Abstract: A drug delivery device that utilizes a fluid subsystem with a switching device to deliver multiple drugs to an animal without causing contamination. The fluid subsystem can further comprise disposable syringes, fluid reservoirs, disposable tubing and a catheter. In the embodiments that utilize multiple disposable syringes, the drug delivery device allows a user to deliver multiple drugs to an animal through a catheter without contaminating the switching devices that control the flow of fluid. The drug delivery device can further utilize a controller to control the switching devices and a controller and syringe pumps to control the operation of the syringes.

Abstract: A method for delivering a fluid to an animal with a drug delivery device without causing contamination to the drug delivery device. The drug delivery device used by the method may comprise a fluid subsystem with a switching device, disposable syringes, fluid reservoirs, disposable tubing, and a catheter. In one embodiment, the method allows a user to deliver multiple drugs to an animal without contaminating the valves that control the flow of fluid.

Abstract: An electrocardiography device and method that is able to obtain the electrocardiogram of a freely moving animal. The device and method utilizes at least two catheters to obtain the electrical signals from the heart of the animal being tested. The catheters are filled with an electrically-conductive, physiological solution and are used in combination with at least two test leads that are able to transfer the electrical signals from the animal to an ECG monitoring device. The device and method also allows for fluids to flow through the catheters to other devices such as a blood sampler controller and/or an infusion pump.

Abstract: A drug delivery device that utilizes a fluid subsystem with a switching device to deliver multiple drugs to an animal without causing contamination. The fluid subsystem can further comprise disposable syringes, fluid reservoirs, disposable tubing and a catheter. In the embodiments that utilize multiple disposable syringes, the drug delivery device allows a user to deliver multiple drugs to an animal through a catheter without contaminating the switching devices that control the flow of fluid. The drug delivery device can further utilize a controller to control the switching devices and a controller and syringe pumps to control the operation of the syringes.

Abstract: The present invention provides an electrocardiography device that is able to obtain the electrocardiogram of a freely moving animal. The present invention utilizes at least two catheters to obtain the electrical signals from the heart of the animal being tested. The catheters are filled with an electrically-conductive, physiological solution and are used in combination with at least two test leads that are able to transfer the electrical signals from the animal to an ECG monitoring device. The present invention also allows for fluids to flow through the catheters to other devices such as a blood sampler controller and/or an infusion pump.

Abstract: A device, system, and method for labeling three-dimensional objects. A sheet comprising at least one tag, each tag consisting of a thin piece of resilient, print-treated polyester, or other material, and a method of attaching the tag to a three-dimensional object, such as a glass or plastic vial, is described. The tag identifies each individual object, and permits transfer of the object throughout a series of analytical processes without losing object identity. The tag is marked by offset printing, laser engraving, or another marking process such that the marking does not become unreadable during handling and testing. Labeling of individual objects is accomplished by inserting an object through an aperture in the tag resulting in the tag being attached to the vial. Removal of the vial from the sheet causes the tag to be separated from the sheet and to remain attached to the vial. Alternatively, a sheet holder, such as a rack, could be used to hold the sheet of tags during the labeling process.

Abstract: A device, system, and method for labeling three-dimensional objects. A sheet comprising at least one tag, each tag consisting of a thin piece of resilient, print-treated polyester, or other material, and a method of attaching the tag to a three-dimensional object, such as a glass or plastic vial, is described. The tag identifies each individual object, and permits transfer of the object throughout a series of analytical processes without losing object identity. The tag is marked by offset printing, laser engraving, or another marking process such that the marking does not become unreadable during handling and testing. Labeling of individual objects is accomplished by inserting an object through an aperture in the tag resulting in the tag being attached to the vial. Removal of the vial from the sheet causes the tag to be separated from the sheet and to remain attached to the vial. Alternatively, a sheet holder, such as a rack, could be used to hold the sheet of tags during the labeling process.

Abstract: A movement-responsive system for conducting tests on freely-moving animals is disclosed. The invention includes a container for housing the animal, a mechanism for rotating the container in response to rotational movement of the animal, and one or more test leads connected to the animal for performance of biomedical tests such as infusion, in vivo ultrafiltration, laser-doppler monitoring of blood flow, electrical stimulation and in vivo microdialysis, and a method for automated micro sampling of body fluids in free-moving animals. Because the cage is rotated in response to the animal's rotational movement, no swivel connectors are needed. A rotational sensor assembly is provided to detect rotational movement of the animal within the container. A vertical sensor assembly is mounted to the counterbalanced arm for monitoring vertical movements of the animal. The outputs of the sensor assemblies are routed to a computer or other device for monitoring and/or analyzing the activity of the animal.

Abstract: A movement-responsive system for conducting tests on freely-moving animals is disclosed. The invention includes a container for housing the animal, a mechanism for rotating the cage in response to rotational movement of the animal, and one or more test leads connected to the animal for performance of biomedical tests such as infusion, in vivo ultrafiltration, laser-doppler monitoring of blood flow, electrical stimulation, and in vivo microdialysis. The container is caused to rotate in the opposite (counter-rotation) direction of the sensed direction of rotation of the animal so that the one or more test leads do not become entangled, twisted, disconnected, or clamped. The rotating mechanism includes a simple, reliable sensor assembly including a pair of strategically placed, close-ended limit detectors which are activated by a triggering element, which is also a part of the sensor assembly.