Patents by Inventor Cantas Alev

Cantas Alev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for inducing osteogenic differentiation
    Patent number: 11859209
    Abstract: The present invention provides a method for inducing osteogenic differentiation, the method comprising the following steps of: (1) culturing pluripotent stem cells under feeder-free conditions, (2) culturing the cells in a mixed culture medium of an osteogenic induction medium and a pluripotent stem cell medium, the mixed culture medium containing a ROCK inhibitor and a retinoic acid receptor ? or ? agonist, and (3) culturing the cells in an osteogenic induction medium containing the retinoic acid receptor ? or ? agonist. The method for inducing osteogenic differentiation according to the present invention is a simple, short-term, highly efficient and highly reproducible one-procedure method for inducing osteogenic differentiation, wherein the method is suitable for bone regeneration therapies, the development of bone metabolic drugs and the development of novel therapies for bone diseases.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: January 2, 2024
    Assignee: KYOTO UNIVERSITY
    Inventors: Junya Toguchida, Shunsuke Kawai, Hiroyuki Yoshitomi, Cantas Alev
  • NOVEL METHOD FOR INDUCING OSTEOGENIC DIFFERENTIATION
    Publication number: 20210087531
    Abstract: The present invention provides a method for inducing osteogenic differentiation, the method comprising the following steps of: (1) culturing pluripotent stem cells under feeder-free conditions, (2) culturing the cells in a mixed culture medium of an osteogenic induction medium and a pluripotent stem cell medium, the mixed culture medium containing a ROCK inhibitor and a retinoic acid receptor ? or ? agonist, and (3) culturing the cells in an osteogenic induction medium containing the retinoic acid receptor ? or ? agonist. The method for inducing osteogenic differentiation according to the present invention is a simple, short-term, highly efficient and highly reproducible one-procedure method for inducing osteogenic differentiation, wherein the method is suitable for bone regeneration therapies, the development of bone metabolic drugs and the development of novel therapies for bone diseases.
    Type: Application
    Filed: December 18, 2018
    Publication date: March 25, 2021
    Inventors: Junya Toguchida, Shunsuke Kawai, Hiroyuki Yoshitomi, Cantas Alev
  • Methods of Prognosing Preeclampsia
    Publication number: 20160018413
    Abstract: Preeclampsia peptide biomarkers are provided. Also provided are methods for using these biomarkers, including in prognosing or diagnosing preeclampsia in a pregnant individual by detecting these biomarkers in a sample from the pregnant individual. Reagents, devices and kits thereof that find use in practicing the subject methods are also provided.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 21, 2016
    Inventors: Bruce Xuefeng Ling, Ting Yang, Atul J. Butte, Linda Liu Miller, Qiaojun Wen, Guojun Sheng, Cantas Alev