Patents by Inventor Cao-Guo Yu

Cao-Guo Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080108127
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.
    Type: Application
    Filed: December 5, 2007
    Publication date: May 8, 2008
    Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANY
    Inventors: Andre Abad, Ronald Flannagan, Rafael Hermann, Albert Lu, Billy McCutchen, James Presnail, Janet Rice, James Wong, Cao-Guo Yu
  • Patent number: 7339092
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: March 4, 2008
    Assignees: Pioneer Hi-Bred International, Inc., E.I. duPont deNemours & Company
    Inventors: Andre Abad, Ronald D. Flannagan, Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, Janet A. Rice, James F. Wong, Cao-Guo Yu
  • Patent number: 7329736
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, novel polynucleotides and the pesticidal polypeptides they encode are provided. Methods of using the novel polynucleotides and pesticidal polypeptides of the invention to protect a plant from an insect pest are further provided. Particular embodiments of the invention provide pesticidal compositions and formulations, DNA constructs, and transformed plants, plant cells, and seeds.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: February 12, 2008
    Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and Company
    Inventors: Andre R. Abad, Ronald D. Flannagan, Billy F. McCutchen, Cao Guo Yu
  • Publication number: 20070243614
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, novel polynucleotides and the pesticidal polypeptides they encode are provided. Methods of using the novel polynucleotides and pesticidal polypeptides of the invention to protect a plant from an insect pest are further provided. Particular embodiments of the invention provide pesticidal compositions and formulations, DNA constructs, and transformed plants, plant cells, and seeds.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 18, 2007
    Inventors: Andre R. Abad, Ronald D. Flannagan, Billy F. McCutchen, Cao Guo Yu
  • Publication number: 20070245430
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, novel polynucleotides and the pesticidal polypeptides they encode are provided. Methods of using the novel polynucleotides and pesticidal polypeptides of the invention to protect a plant from an insect pest are further provided. Particular embodiments of the invention provide pesticidal compositions and formulations, DNA constructs, and transformed plants, plant cells, and seeds.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 18, 2007
    Inventors: Andre R. Abad, Ronald D. Flannagan, Billy F. McCutchen, Cao Guo Yu
  • Patent number: 7214860
    Abstract: Methods of creating and enhancing insect resistance in plants by introducing non-plant lipases into plants are provided. Plants with enhanced insect resistance and seed from plants thereof are provided. DNA sequences encoding insecticidal lipases and insecticidal lipase gene products that are useful in the practice of this invention are also provided. The compositions and methods of the invention may be used in a variety of agricultural systems for controlling pests, including propagating lineages of insect-resistant crops and targeting expression of these insecticidal lipases to plant organs that are particularly susceptible to infestation, such as roots and leaves.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: May 8, 2007
    Assignees: Pioneer Hi-Bred International, Inc., E. I. du Pont de Nemours and Company
    Inventors: Billy F. McCutchen, Andre R. Abad, James F. Wong, Cao Guo Yu
  • Patent number: 7105332
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: September 12, 2006
    Assignee: E.I. Du Pont de Nemours and Company
    Inventors: André Abad, Ronald D. Flannagan, Rafael Herrmann, Theodore W. Kahn, Albert L. Lu, Billy F. McCutchen, James K. Presnail, James F. H. Wong, Cao-Guo Yu
  • Publication number: 20050261188
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: April 18, 2005
    Publication date: November 24, 2005
    Applicant: E.I. du PONT de NEMOURS and COMPANY
    Inventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Theodore Kahn, Albert Lu, Billy McCutchen, James Presnail, James Wong, Cao-Guo Yu
  • Publication number: 20050261483
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: February 15, 2005
    Publication date: November 24, 2005
    Applicant: E.I. duPont de Nemours and Company
    Inventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Theodore Kahn, Albert Lu, Billy McCutchen, James Presnail, James Wong, Cao-Guo Yu
  • Publication number: 20050166284
    Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.
    Type: Application
    Filed: December 22, 2004
    Publication date: July 28, 2005
    Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANY
    Inventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Albert Lu, Billy McCutchen, James Presnail, Janet Rice, James Wong, Cao-Guo Yu
  • Publication number: 20040091505
    Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding &dgr;-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: June 25, 2003
    Publication date: May 13, 2004
    Applicant: E.I du Pont de Nemours and Company
    Inventors: Andre R. Abad, Ronald D. Flannagan, Rafael Herrmann, Theodore W. Kahn, Albert L. Lu, Billy Fred McCutchen, James K. Presnail, James F.H. Wong, Cao-Guo Yu
  • Patent number: 6291156
    Abstract: The present invention is drawn to a novel class of proteins, and their receptors. Novel processes, assays and methods for controlling plant pests are provided.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: September 18, 2001
    Assignee: Syngenta Participations AG
    Inventors: Juan Jose Estruch, Cao-Guo Yu
  • Patent number: 6107279
    Abstract: The genes encoding a novel class of insecticidal proteins have been isolated and characterized from a strain of Bacillus thuringiensis. Both the nucleic and amino acid sequences for the proteins are disclosed. The nucleic acid molecules are utilized in the transformation of host microorganisms and production of transgenic plants which are resistant to insects. Also, the gene encoding for the insect's receptor of the insecticidal protein has been isolated and characterized. Novel processes and methods for controlling plants pests are provided.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: August 22, 2000
    Assignee: Novartis Finance Corporation
    Inventors: Juan J. Estruch, Cao-Guo Yu, Gregory W. Warren, Nalini M. Desai, Michael G. Koziel, Gordon J. Nye
  • Patent number: 5877012
    Abstract: The present invention is drawn to a novel class of proteins, and their receptors. Novel processes, assays and methods for controlling plant pests are provided.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: March 2, 1999
    Assignee: Novartis Finance Corporation
    Inventors: Juan J. Estruch, Cao-Guo Yu, Gregory W. Warren, Nalini M. Desai, Michael G. Koziel, Gordon J. Nye