Patents by Inventor Cao Lv

Cao Lv has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250213484
    Abstract: Provided is a freeze-drying process for an antibody drug conjugate, wherein the ADC is GQ1001. Due to the use of the present freeze-drying process parameters, especially the suitable pre-freezing cooling rate and a suitable drying vacuum, the product obtained by the process has many advantages in physical and chemical properties.
    Type: Application
    Filed: March 29, 2023
    Publication date: July 3, 2025
    Inventors: Gang QIN, Bian GUO, Xuesong LI, Lili SHI, Cao LV
  • Publication number: 20250043005
    Abstract: Provided are antibody-cytokine fusion proteins comprising an anti-PD-L1 antibody and an Interleukin 21, and methods for preparing the same, as well as applications of the fusion proteins for therapeutic purpose.
    Type: Application
    Filed: December 8, 2022
    Publication date: February 6, 2025
    Inventors: Gang QIN, Paul H. SONG, Dong YANG, Cao LV
  • Publication number: 20240398960
    Abstract: A method for preparing an antibody-drug conjugate. The antibody-drug conjugate is formed by means of site-directed conjugation on the basis of an N-glycosylation site of an Fc region of an antibody. The method comprises: (1) providing a donor containing an oxazoline oligosaccharide, an antibody containing a GlcNAc motif, and an immobilized endoglycosidase having a glycoside transfer activity; and (2) covalently linking the activated donor containing the oxazoline oligosaccharide to the antibody containing the GlcNAc motif by means of the catalytic action of the endoglycosidase; therefore, one-step conjugation is realized. The present invention also relates to an endoglycosidase fusion protein, which comprises a covalently linked endoglycosidase, a Halo tag, and/or a His tag.
    Type: Application
    Filed: July 29, 2024
    Publication date: December 5, 2024
    Inventors: Cao LV, Jinduo YUAN, Gang QIN, Meijun XIONG
  • Publication number: 20240287432
    Abstract: A conjugation device includes at least one flow reactor having an inlet and an outlet, the flow reactor(s) being completely filled with a support such as a matrix including 1) chromatography beads, fibers or membranes, and 2) a biologic catalyzer, namely the enzyme ligase, which is immobilized onto this support; a fluid delivery unit in fluid communication with the inlet of the flow reactor(s) and configured to continuously provide the flow reactor(s) with at least one kind of reaction fluid such as antibody and linker-payload according to stages of the conjugation process, the at least one kind of process fluid including a first moiety and a second moiety of a conjugate to be produced; and a fluid collection unit in fluid communication with the outlet of the flow reactor(s) and configured to control collection of fluid flowing out of the outlet of the flow reactor(s) according to the stages of the conjugation process.
    Type: Application
    Filed: May 7, 2024
    Publication date: August 29, 2024
    Inventors: Gang QIN, Sheng ZHOU, Cao LV, Joachim WALTER
  • Patent number: 12012582
    Abstract: A conjugation device includes at least one flow reactor having an inlet and an outlet, the flow reactor(s) being completely filled with a support such as a matrix including 1) chromatography beads, fibers or membranes, and 2) a biologic catalyzer, namely the enzyme ligase, which is immobilized onto this support; a fluid delivery unit in fluid communication with the inlet of the flow reactor(s) and configured to continuously provide the flow reactor(s) with at least one kind of reaction fluid such as antibody and linker-payload according to stages of the conjugation process, the at least one kind of process fluid including a first moiety and a second moiety of a conjugate to be produced; and a fluid collection unit in fluid communication with the outlet of the flow reactor(s) and configured to control collection of fluid flowing out of the outlet of the flow reactor(s) according to the stages of the conjugation process.
    Type: Grant
    Filed: January 5, 2023
    Date of Patent: June 18, 2024
    Assignees: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD., LISURE SCIENCE (SUZHOU) CO., LTD
    Inventors: Gang Qin, Sheng Zhou, Cao Lv, Joachim Walter
  • Publication number: 20240165192
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Application
    Filed: January 11, 2024
    Publication date: May 23, 2024
    Inventors: Gang QIN, Jinduo YUAN, Lu JIANG, Chubing TAN, Lili SHI, Cao LV, Leilei CHEN
  • Publication number: 20240156894
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Application
    Filed: January 10, 2024
    Publication date: May 16, 2024
    Inventors: Gang QIN, Jinduo YUAN, Lu JIANG, Chubing TAN, Lili SHI, Cao LV, Leilei CHEN
  • Patent number: 11911435
    Abstract: A conjugate and preparation method therefor, comprising a medication composition comprising the conjugate and a use of the medication composition in preparing medications for the treatment or prevention of diseases.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: February 27, 2024
    Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • Patent number: 11911434
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: February 27, 2024
    Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • Patent number: 11834688
    Abstract: The present disclosure relates to the field of biotechnology. In particular, provided are a ligase fusion protein and an immobilized ligase comprising the same. Also provided is use of the ligase fusion protein or the immobilized ligase in the preparation of conjugates. Further provided is a process for the preparation of conjugates using a ligase or a ligase unit.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: December 5, 2023
    Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Cao Lv, Joachim Walter, Rolf Werner, Yunpeng Zhong
  • Publication number: 20230159875
    Abstract: A conjugation device includes at least one flow reactor having an inlet and an outlet, the flow reactor(s) being completely filled with a support such as a matrix including 1) chromatography beads, fibers or membranes, and 2) a biologic catalyzer, namely the enzyme ligase, which is immobilized onto this support; a fluid delivery unit in fluid communication with the inlet of the flow reactor(s) and configured to continuously provide the flow reactor(s) with at least one kind of reaction fluid such as antibody and linker-payload according to stages of the conjugation process, the at least one kind of process fluid including a first moiety and a second moiety of a conjugate to be produced; and a fluid collection unit in fluid communication with the outlet of the flow reactor(s) and configured to control collection of fluid flowing out of the outlet of the flow reactor(s) according to the stages of the conjugation process.
    Type: Application
    Filed: January 5, 2023
    Publication date: May 25, 2023
    Inventors: Gang QIN, Sheng ZHOU, Cao LV, Joachim WALTER
  • Publication number: 20230097252
    Abstract: The present disclosure relates to the field of biotechnology. In particular, provided are a ligase fusion protein and an immobilized ligase comprising the same. Also provided is use of the ligase fusion protein or the immobilized ligase in the preparation of conjugates. Further provided is a process for the preparation of conjugates using a ligase or a ligase unit.
    Type: Application
    Filed: July 27, 2022
    Publication date: March 30, 2023
    Inventors: Gang QIN, Cao LV, Joachim WALTER, Rolf WERNER, Yunpeng ZHONG
  • Patent number: 11578297
    Abstract: A conjugation device includes at least one flow reactor having an inlet and an outlet, the flow reactor(s) being completely filled with a support such as a matrix including 1) chromatography beads, fibers or membranes, and 2) a biologic catalyzer, namely the enzyme ligase, which is immobilized onto this support; a fluid delivery unit in fluid communication with the inlet of the flow reactor(s) and configured to continuously provide the flow reactor(s) with at least one kind of reaction fluid such as antibody and linker-payload according to stages of the conjugation process, the at least one kind of process fluid including a first moiety and a second moiety of a conjugate to be produced; and a fluid collection unit in fluid communication with the outlet of the flow reactor(s) and configured to control collection of fluid flowing out of the outlet of the flow reactor(s) according to the stages of the conjugation process.
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: February 14, 2023
    Assignees: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD., LISURE SCIENCE (SUZHOU) CO., LTD
    Inventors: Gang Qin, Sheng Zhou, Cao Lv, Joachim Walter
  • Publication number: 20220403360
    Abstract: The present disclosure relates to the field of biotechnology. In particular, provided are a ligase fusion protein and an immobilized ligase comprising the same. Also provided is use of the ligase fusion protein or the immobilized ligase in the preparation of conjugates. Further provided is a process for the preparation of conjugates using a ligase or a ligase unit.
    Type: Application
    Filed: July 19, 2022
    Publication date: December 22, 2022
    Inventors: Gang QIN, Cao LV, Joachim WALTER, Rolf WERNER, Yunpeng ZHONG
  • Patent number: 11453870
    Abstract: The present disclosure relates to the field of biotechnology. In particular, provided are a ligase fusion protein and an immobilized ligase comprising the same. Also provided is use of the ligase fusion protein or the immobilized ligase in the preparation of conjugates. Further provided is a process for the preparation of conjugates using a ligase or a ligase unit.
    Type: Grant
    Filed: July 13, 2021
    Date of Patent: September 27, 2022
    Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO. LTD.
    Inventors: Gang Qin, Cao Lv, Joachim Walter, Rolf Werner, Yunpeng Zhong
  • Publication number: 20220251530
    Abstract: The present disclosure relates to the field of biotechnology. In particular, provided are a ligase fusion protein and an immobilized ligase comprising the same. Also provided is use of the ligase fusion protein or the immobilized ligase in the preparation of conjugates. Further provided is a process for the preparation of conjugates using a ligase or a ligase unit.
    Type: Application
    Filed: July 13, 2021
    Publication date: August 11, 2022
    Inventors: Gang QIN, Cao LV, Joachim WALTER, Rolf WERNER, Yunpeng ZHONG
  • Publication number: 20220251494
    Abstract: A conjugation device includes at least one flow reactor having an inlet and an outlet, the flow reactor(s) being completely filled with a support such as a matrix including 1) chromatography beads, fibers or membranes, and 2) a biologic catalyzer, namely the enzyme ligase, which is immobilized onto this support; a fluid delivery unit in fluid communication with the inlet of the flow reactor(s) and configured to continuously provide the flow reactor(s) with at least one kind of reaction fluid such as antibody and linker-payload according to stages of the conjugation process, the at least one kind of process fluid including a first moiety and a second moiety of a conjugate to be produced; and a fluid collection unit in fluid communication with the outlet of the flow reactor(s) and configured to control collection of fluid flowing out of the outlet of the flow reactor(s) according to the stages of the conjugation process.
    Type: Application
    Filed: February 9, 2022
    Publication date: August 11, 2022
    Inventors: Gang QIN, Sheng ZHOU, Cao LV, Joachim WALTER
  • Publication number: 20210401924
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Application
    Filed: February 19, 2021
    Publication date: December 30, 2021
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • Patent number: 11040084
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: June 22, 2021
    Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • Publication number: 20210177929
    Abstract: A conjugate and preparation method therefor, comprising a medication composition comprising the conjugate and a use of the medication composition in preparing medications for the treatment or prevention of diseases.
    Type: Application
    Filed: February 19, 2021
    Publication date: June 17, 2021
    Applicant: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen