Patents by Inventor Cara B. GONZALES

Cara B. GONZALES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200157637
    Abstract: Methods for identifying patients with high risk (progression, invasion, metastasis) squamous cell carcinoma using methylation and/or expression assays are disclosed. Also provided are methods of treating such high risk cancers with ALK inhibitors combined with anti-EGFR based therapies, as the data show a correlation between ALK hypomethylation and EGFR activation.
    Type: Application
    Filed: May 23, 2018
    Publication date: May 21, 2020
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cara B. GONZALES, Nameer KIRMA
  • Publication number: 20200069607
    Abstract: Provided are oral delivery compositions, including mouthwashes, for the delivery of thymol to a subject at risk of or having oral cancer.
    Type: Application
    Filed: November 22, 2017
    Publication date: March 5, 2020
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Cara B. GONZALES
  • Publication number: 20200024276
    Abstract: The present disclosure relates generally to derivatives of capsazepine and methods of use thereof. In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases.
    Type: Application
    Filed: September 6, 2019
    Publication date: January 23, 2020
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cara B. GONZALES, Stanton McHARDY
  • Patent number: 10457676
    Abstract: The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the disclosure provides capsazepine derivatives which may be useful in the treatment of cancer. Such cancers that the compounds may be used to treating include but are not limited to breast, cervical, oral, head, neck, or prostate cancer. In some aspects, the compounds may be useful in treating a tumor by direct injection of the compound into the tumor, particularly an oral tumor. In other aspects, the compounds are administered systemically. The compounds of the present disclosure may also be used to treat the pain associated with a tumor for which it is being administered.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: October 29, 2019
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cara B. Gonzales, Stanton McHardy
  • Publication number: 20180237362
    Abstract: The present disclosure relates generally to derivatives of polygodial and methods of use thereof. In some aspects, the present disclosure relates to using polygodial derivatives to treat cancer or other hyperproliferative diseases.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 23, 2018
    Inventors: Cara B. GONZALES, Alexander KORNIENKO, Ramesh DASARI
  • Publication number: 20170275280
    Abstract: The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the disclosure provides capsazepine derivatives which may be useful in the treatment of cancer. Such cancers that the compounds may be used to treating include but are not limited to breast, cervical, oral, head, neck, or prostate cancer. In some aspects, the compounds may be useful in treating a tumor by direct injection of the compound into the tumor, particularly an oral tumor. In other aspects, the compounds are administered systemically. The compounds of the present disclosure may also be used to treat the pain associated with a tumor for which it is being administered.
    Type: Application
    Filed: August 25, 2015
    Publication date: September 28, 2017
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cara B. GONZALES, Stanton McHARDY
  • Patent number: 9642859
    Abstract: Disclosed are methods and compositions for treating cancer, particularly for reducing cancerous cell growth, for example, in solid tumors. Disclosed methods and compositions include capsazepine (CPZ) or an analog of CPZ. Compositions comprising CPZ or an analog of CPZ may be useful for simultaneously treating cancer and alleviating pain by blocking TRPV1 channels.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: May 9, 2017
    Assignee: The Board of Regents of the University of Texas System
    Inventor: Cara B. Gonzales
  • Publication number: 20150352123
    Abstract: Disclosed are methods and compositions for treating cancer, particularly for reducing cancerous cell growth, for example, in solid tumors. Disclosed methods and compositions include capsazepine (CPZ) or an analog of CPZ. Compositions comprising CPZ or an analog of CPZ may be useful for simultaneously treating cancer and alleviating pain by blocking TRPV1 channels.
    Type: Application
    Filed: December 3, 2013
    Publication date: December 10, 2015
    Inventor: Cara B. GONZALES