Patents by Inventor Cara B. Marks

Cara B. Marks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human tissue plasminogen activator variants
    Patent number: 5770425
    Abstract: Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: June 23, 1998
    Assignee: Genentech, Inc.
    Inventors: Stephen P. Anderson, Deborah L. Higgins, Adair J. Hotchkiss, Cara B. Marks
  • Human tissue plasminogen activator variant
    Patent number: 5366886
    Abstract: Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: November 22, 1994
    Assignee: Genentech, Inc.
    Inventors: Stephen P. Anderson, Deborah L. Higgins, Adair J. Hotchkiss, Cara B. Marks
  • Human tissue plasminogen activator variants
    Patent number: 5314818
    Abstract: Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: May 24, 1994
    Assignee: Genentech, Inc.
    Inventors: Stephen P. Anderson, Deborah L. Higgins, Adair J. Hotchkiss, Cara B. Marks
  • Human tissue plasminogen activator variants
    Patent number: 5094953
    Abstract: Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: March 10, 1992
    Assignee: Genentech, Inc.
    Inventors: Stephen P. Anderson, Deborah L. Higgins, Adair J. Hotchkiss, Cara B. Marks