Patents by Inventor Cara-Lin Lonetree

Cara-Lin Lonetree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lymphohematopoietic engineering using CAS9 base editors
    Patent number: 12281327
    Abstract: Provided herein are methods and systems for targeted gene disruption (knock-out, missense mutation) and targeted gene knock-in in mammalian cells using base editors and guide RNAs (gRNAs) designed to target splice acceptor-splice donor sites. Also provided herein are universally acceptable genetically engineered cells comprising targeted disruptions in immunotherapy-related genes and comprising a CAR/TCR for therapeutic applications.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: April 22, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Branden Moriarity, Beau Webber, Cara-Lin Lonetree, Miechaleen Diers, Mitchell Kluesner, Walker Lahr, Emily Joy Pomeroy
  • LYMPHOHEMATOPOIETIC ENGINEERING USING CAS9 BASE EDITORS
    Publication number: 20210040507
    Abstract: Provided herein are methods and systems for targeted gene disruption (knock-out, missense mutation) and targeted gene knock-in in mammalian cells using base editors and guide RNAs (gRNAs) designed to target splice acceptor-splice donor sites. Also provided herein are universally acceptable genetically engineered cells comprising targeted disruptions in immunotherapy-related genes and comprising a CAR/TCR for therapeutic applications.
    Type: Application
    Filed: March 13, 2019
    Publication date: February 11, 2021
    Inventors: Branden Moriarity, Beau Webber, Cara-Lin Lonetree, Miechaleen Diers, Mitchell Kluesner, Walker Lahr, Emily Joy Pomeroy