Patents by Inventor Carina Horn

Carina Horn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11221324
    Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: January 11, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Heino Eikmeier, Hans-Peter Haar, Joachim Hoenes, Carina Horn, Ewald Rieger
  • Patent number: 11220674
    Abstract: The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: January 11, 2022
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Carina Horn, Dieter Heindl, Claudia Gaessler-Dietsche, Joachim Hoenes
  • Publication number: 20210382042
    Abstract: The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule.
    Type: Application
    Filed: August 20, 2021
    Publication date: December 9, 2021
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Grit Baier, Carina Horn, Katharina Landfester, Anna Musyanovych, Umaporn Paiphansiri
  • Patent number: 11105800
    Abstract: The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: August 31, 2021
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Grit Baier, Carina Horn, Katharina Landfester, Anna Musyanovych, Umaporn Paiphansiri
  • Patent number: 11090650
    Abstract: A method for manufacturing a test element for detecting at least one analyte in a body fluid, a test element for detecting at least one analyte in a body fluid, a method for detecting at least one analyte in a body fluid, a system for detecting at least one analyte in a body fluid and a method for manufacturing a test element for detecting at least one analyte in a body fluid are disclosed.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: August 17, 2021
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Joerg Dreibholz, Volker Hullen, Maria Dambach, Herbert Fink, Daniela Pfiffi, Bernd Hiller, Carina Horn
  • Patent number: 11029309
    Abstract: The present invention relates to a detector matrix for detecting at least one analyte in a sample, preferably a sample of a body fluid, comprising at least one enzyme active in the presence of said at least one analyte and at least one indicator reagent changing at least one optical property dependent on the activity of said enzyme, wherein said detector matrix further comprises up-converting phosphor particles, preferably UV-emitting up-converting phosphor particles. The invention further relates to a test element and a test device for detecting at least one analyte in a sample comprising the detector matrix of the invention, as well as to a method for the manufacture of a detector matrix, a method for the manufacture of a test element, and to a method for detecting an analyte in a sample, comprising contacting a detector matrix according to the invention with a sample suspected to comprise said analyte.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: June 8, 2021
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Timo-Jaakko Valta
  • Patent number: 10984892
    Abstract: Methods are provided for detecting an analyte concentration/presence in a body fluid sample that include providing a set of at least two different evaluation rules, each evaluation rule adapted to derive a set characteristic values from an optical measurement curve, where at least one first characteristic value is derived from at least one first evaluation rule and at least one second characteristic value is derived from at least one second evaluation rule. The methods also include performing at least one multivariate analysis of the at least one first and second characteristic values by using at least one predetermined multivariate evaluation algorithm to derive at least one estimate value for at least one target variable Y of the state variables. The methods also include determining at least one analyte concentration by using the at least one target variable Y. Also provided are computer programs and devices that incorporate the same.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: April 20, 2021
    Inventors: Simon Aigner, Gabriele Chemnitius, Carina Horn, Bernd Limburg, Timo Ottenstein, Wolfgang Petrich, Markus Plum, Christian Ringemann, Markus Serr
  • Publication number: 20200225184
    Abstract: A method for determining an information on an equivalent series resistance is disclosed and comprises: generating at least one excitation voltage signal and applying the excitation voltage to at least two measurement electrodes; measuring a response signal; determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and determining the information on the equivalent series resistance from the ohmic signal portion.
    Type: Application
    Filed: March 25, 2020
    Publication date: July 16, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Michael Lambertson, Klaus Bauer-Espindola, Samuel Evgin, Carina Horn, Michael Marquant
  • Patent number: 10704029
    Abstract: The present invention relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell comprising the mutant 3-HBDH or the nucleic acid, a method of determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: July 7, 2020
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Daniela Beck, Mara Boenitz-Dulat, Peter Kratzsch, Thomas Streidl, Carina Horn
  • Publication number: 20200087633
    Abstract: The present invention relates to improved variants of variants of the Glucose Dehydrogenases (GlucDH) derived from Bacillus subtilis having improved properties in the presence of cNAD as cofactor, to genes encoding such variant GlucDHs, to proteins of such GlucDH variants, and to different applications of these GlucDH variants, particularly for determining concentrations of sugars, especially of glucose, in samples such as bodily fluids, especially blood.
    Type: Application
    Filed: December 22, 2017
    Publication date: March 19, 2020
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Mara Boenitz-Dulat, Carina Horn, Peter Kratzsch, Thomas Meier, Markus Rudolph, Bernd Schneidinger
  • Publication number: 20190325992
    Abstract: Methods are provided for detecting an analyte concentration/presence in a body fluid sample that include providing a set of at least two different evaluation rules, each evaluation rule adapted to derive a set characteristic values from an optical measurement curve, where at least one first characteristic value is derived from at least one first evaluation rule and at least one second characteristic value is derived from at least one second evaluation rule. The methods also include performing at least one multivariate analysis of the at least one first and second characteristic values by using at least one predetermined multivariate evaluation algorithm to derive at least one estimate value for at least one target variable Y of the state variables. The methods also include determining at least one analyte concentration by using the at least one target variable Y. Also provided are computer programs and devices that incorporate the same.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Inventors: Simon Aigner, Gabriele Chemnitius, Carina Horn, Bernd Limburg, Timo Ottenstein, Wolfgang Petrich, Markus Plum, Christian Ringemann, Markus Serr
  • Patent number: 10400233
    Abstract: Methods of cross-linking polypeptide molecules are provided, where such methods include combining a cross-linking agent and polypeptide molecules in a solution under conditions suitable for a cross-linking reaction to occur. Also provided are preparations of cross-linked polypeptide molecules, where the polypeptide molecules are cross-linked by essentially unbranched cross-linking groups of at least 40 contiguous atoms. Further provided are test chemistry matrices and methods of making the same, where the matrices include a redox cofactor, an agent capable of eliciting a change in at least one measurable property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and a preparation of cross-linked polypeptide molecules as described herein. Test elements and methods of using the same to diagnose diseases such as diabetes also are provided, where the test elements include a test chemistry matrix as described herein.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: September 3, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Susanne Gawenda
  • Publication number: 20190113506
    Abstract: The present invention relates to a detector matrix for detecting at least one analyte in a sample, preferably a sample of a body fluid, comprising at least one enzyme active in the presence of said at least one analyte and at least one indicator reagent changing at least one optical property dependent on the activity of said enzyme, wherein said detector matrix further comprises up-converting phosphor particles, preferably UV-emitting up-converting phosphor particles. The invention further relates to a test element and a test device for detecting at least one analyte in a sample comprising the detector matrix of the invention, as well as to a method for the manufacture of a detector matrix, a method for the manufacture of a test element, and to a method for detecting an analyte in a sample, comprising contacting a detector matrix according to the invention with a sample suspected to comprise said analyte.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Timo-Jaakko Valta
  • Patent number: 10260085
    Abstract: In one form, a diagnostic element for determining at least one analyte is provided. In a further form, an analytical measuring device includes the diagnostic element. Still, other forms are related to methods for the determination of an analyte, correcting a signal generated by an analyte, and/or checking the detection optics of an analytical measuring device using the diagnostic element. Another form is related to a system for the controlled release of a reagent and the use of such a system as a circuit element. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving diagnostic elements.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: April 16, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Dieter Heindl, Hans-Peter Haar, Nelli Steinke
  • Publication number: 20190049427
    Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.
    Type: Application
    Filed: October 15, 2018
    Publication date: February 14, 2019
    Inventors: Heino Eikmeier, Hans-Peter Haar, Joachim Hoenes, Carina Horn, Ewald Rieger
  • Patent number: 10190988
    Abstract: Methods are provided for manufacturing disposable diagnostic test elements via laser welding, where the methods include providing, in a stacked or layered arrangement, a base layer, a cover layer, and optionally an intermediate layer, where one of the layers is an absorbing layer and at least one other of the layers is a transparent layer, and where one of the layers includes a coating adapted to interact with a body fluid sample when conducting a test on the resulting test element; directing a laser beam in a weld area through the at least one transparent layer and against the absorbing layer; and fusing the transparent and the absorbing layers together to form the test element, where the coating covers the weld area at least in part and absorbs and/or scatters radiation from the laser beam at least in part. Disposable diagnostic test elements also are provided.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: January 29, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Branislav Babic, Carina Horn
  • Patent number: 10180420
    Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: January 15, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Klaus Andreas Bauer-Espindola, Carina Horn, Michael Marquant, Christine Nortmeyer, Volker Unkrig
  • Patent number: 10168321
    Abstract: The present invention relates to a detector matrix for detecting at least one analyte in a sample, preferably a sample of a body fluid, comprising at least one enzyme active in the presence of said at least one analyte and at least one indicator reagent changing at least one optical property dependent on the activity of said enzyme, wherein said detector matrix further comprises up-converting phosphor particles, preferably UV-emitting up-converting phosphor particles. The invention further relates to a test element and a test device for detecting at least one analyte in a sample comprising the detector matrix of the invention, as well as to a method for the manufacture of a detector matrix, a method for the manufacture of a test element, and to a method for detecting an analyte in a sample, comprising contacting a detector matrix according to the invention with a sample suspected to comprise said analyte.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: January 1, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Timo-Jaakko Valta
  • Patent number: 10167497
    Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: January 1, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Dieter Heindl, Joachim Hoenes, Carina Horn, Claudia Gaessler-Dietsche
  • Publication number: 20180346886
    Abstract: The present invention relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell comprising the mutant 3-HBDH or the nucleic acid, a method of determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
    Type: Application
    Filed: August 9, 2018
    Publication date: December 6, 2018
    Inventors: Daniela Beck, Mara Boenitz-Dulat, Peter Kratzsch, Thomas Streidl, Carina Horn