Patents by Inventor Carine Capiau

Carine Capiau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glutaraldehyde and formalin detoxified bordetella toxin vaccine
    Patent number: 5578308
    Abstract: A detoxified B. pertussis toxin or antigenic preparation is described, which is characterized by stability to reversion to toxicity upon storage at 4.degree.-8.degree. C. and at temperatures above 23.degree. C. Also provided are methods for producing detoxified pertussis toxin and vaccines containing same.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: November 26, 1996
    Inventors: Carine Capiau, Jean Petre
  • Method for isolating and purifying bordetella pertussis antigenic factors
    Patent number: 5391715
    Abstract: A process is provided for the purification of pertussis toxin (PT) and/or filamentous hemagglutinin antigen (FHA) from a B. pertussis fermentation broth or cell free culture supernatant containing at least one antigen, which comprises contacting the fermenation broth or cell free culture supernatant with a hydroxyapatite adsorbent for a sufficient time to adsorb the antigen(s) at a pH which both PT and FHA are adsorbed and eluting a mixture containing the adsorbed antigen(s) from the adsorbent with eluant at a pH which both PT and FHA are eluted. The PT and FHA may be further purified by two sequential chromatographic columns, one of which involves apolar-ligand chromatography.
    Type: Grant
    Filed: March 24, 1992
    Date of Patent: February 21, 1995
    Assignee: SmithKline Beecham Biologicals
    Inventors: Carine Capiau, Pierre Desmons