Patents by Inventor Carl A. Genberg
Carl A. Genberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230372362Abstract: Methods of treating, reducing, or preventing lung infections and/or lung inflammation include identifying a patient in need of treatment and administering a therapeutically or prophylactically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Treatment of cystic fibrosis lung infections, COPD lung infections, inflammation of the lungs in these patient populations, and lung scarring in these patient populations is also described.Type: ApplicationFiled: April 17, 2023Publication date: November 23, 2023Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Carl A. Genberg, Michael D. Triplett
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Patent number: 11739116Abstract: Compositions and methods for treating, reducing, or preventing a disease or symptom such as gingivitis, periodontitis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, or pain. The method includes identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: GrantFiled: March 13, 2014Date of Patent: August 29, 2023Assignee: Brigham Young UniversityInventors: Paul B. Savage, Carl Genberg
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Patent number: 11690855Abstract: Methods of treating, reducing, or preventing lung infections or lung inflammation include identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Treatment of cystic fibrosis lung infections, COPD lung infections, inflammation of the lungs in these patient populations, and lung scarring in these patient populations is also described.Type: GrantFiled: October 16, 2014Date of Patent: July 4, 2023Assignee: Brigham Young UniversityInventors: Paul B. Savage, Carl A. Genberg, Michael D. Triplett
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Patent number: 11524015Abstract: Disclosed herein are methods of treating, reducing, or preventing a disease such as oral mucositis, gastric mucositis, or inflammatory fibrosis, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: GrantFiled: July 25, 2014Date of Patent: December 13, 2022Assignee: Brigham Young UniversityInventors: Paul B. Savage, Carl A. Genberg
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Patent number: 11253634Abstract: This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.Type: GrantFiled: November 8, 2018Date of Patent: February 22, 2022Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Carl Genberg, Ronald Bracken
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Publication number: 20210361672Abstract: The present disclosure describes compositions and methods for preventing and/or treating microbial infections of ciliated tissues, such as tissues of the trachea, lungs, and sinuses. A treatment composition comprises a CSA compound, a poloxamer, and a carrier. The combination of CSA compound and poloxamer allows higher concentrations of CSA compound to be used. Where such doses would normally disrupt ciliary function, the poloxamer prevents damage to ciliated tissue without inhibiting the antimicrobial effectiveness of the CSA compound.Type: ApplicationFiled: March 7, 2019Publication date: November 25, 2021Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Paul B. Savage
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Patent number: 10568893Abstract: Methods of treating, reducing, or preventing a disease or symptom relating to a disease such as oral mucositis, gingivitis, periodontitis, gastric mucositis, inflammatory fibrosis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, inflammation associated with cancer, cancer treatment, or radiation, and/or pain that include: identifying a patient in need of treatment; and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: GrantFiled: October 1, 2015Date of Patent: February 25, 2020Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Carl Genberg
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Patent number: 10441595Abstract: Disclosed herein are methods of treating fungal infections in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: GrantFiled: June 25, 2015Date of Patent: October 15, 2019Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Chad S. Beus, Paul B. Savage
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Patent number: 10238665Abstract: Disclosed herein are methods of treating fungal infections in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: GrantFiled: May 3, 2017Date of Patent: March 26, 2019Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Chad S. Beus, Paul B. Savage
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Publication number: 20190076581Abstract: This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.Type: ApplicationFiled: November 8, 2018Publication date: March 14, 2019Inventors: Paul B. Savage, Carl Genberg, Ronald Bracken
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Patent number: 10226550Abstract: This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.Type: GrantFiled: March 9, 2017Date of Patent: March 12, 2019Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Carl Genberg, Ronald Bracken
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Patent number: 10195215Abstract: Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: GrantFiled: February 13, 2018Date of Patent: February 5, 2019Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Paul B. Savage
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Publication number: 20180272034Abstract: This disclosure describes the use of cationic steroidal antimicrobial (CSA) compounds to prevent microbial fouling of medical implants, including microbial fouling caused by bacterial and/or fungal biofilms. The CSAs are incorporated into the medical implants to provide effective antimicrobial properties. A medical implant includes a component formed from a polymeric material. A plurality of CSA molecules are mixed with the polymeric material so that the CSA molecules are incorporated into the structure of the medical implant as formed. A medical implant can additionally or alternatively include a lubricious coating containing CSA molecules.Type: ApplicationFiled: March 20, 2018Publication date: September 27, 2018Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Carl Genberg, Ronald L. Bracken
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Patent number: 10039285Abstract: Particulate ceragenin materials may be manufactured by (i) providing a ceragenin feed material comprised of ceragenin molecules, each having a sterol backbone and a plurality cationic groups attached thereto; (ii) fracturing the ceragenin feed material in a milling apparatus to produce a ceragenin particulate material having a particle size distribution with a median particle size in a range from 5 nm to 20 ?m; and (iii) during fracturing, maintaining the ceragenin feed with a moisture content of less than or equal to 10% by weight.Type: GrantFiled: March 13, 2013Date of Patent: August 7, 2018Assignee: Brigham Young UniversityInventors: Paul B. Savage, Carl Genberg
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Publication number: 20180169114Abstract: Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: ApplicationFiled: February 13, 2018Publication date: June 21, 2018Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Paul B. Savage
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Patent number: 9943529Abstract: Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: GrantFiled: January 7, 2014Date of Patent: April 17, 2018Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Paul B. Savage
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Patent number: 9931350Abstract: Cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making and using the same. Particularly advantageous uses include treating infections in patient and sub-patient populations, especially those having a bone disease, a broken bone, a bone infection, or a bone implant.Type: GrantFiled: March 11, 2015Date of Patent: April 3, 2018Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Carl Genberg
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Publication number: 20170258963Abstract: This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.Type: ApplicationFiled: March 9, 2017Publication date: September 14, 2017Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Carl Genberg, Ronald Bracken
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Publication number: 20170232004Abstract: Disclosed herein are methods of treating fungal infections in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: ApplicationFiled: May 3, 2017Publication date: August 17, 2017Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Chad S. Beus, Paul B. Savage
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Patent number: 9694019Abstract: Disclosed herein are methods of promoting osteogenesis in a subject, comprising administering a composition comprising a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA). Also disclosed herein are methods of promoting osteogenesis in a subject in need of such promotion, comprising administering a composition comprising a therapeutically effective amount of at least one CSA. Additionally, disclosed herein are compounds and compositions comprising at least one CSA, or a pharmaceutically acceptable salt thereof, for use in the treatment of bone disease or the treatment of broken bones. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: GrantFiled: September 1, 2015Date of Patent: July 4, 2017Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Paul B. Savage