Patents by Inventor Carl A. Myerholtz

Carl A. Myerholtz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140217276
    Abstract: Provided herein are systems and method for using unit mass library searches for sample identification in accurate mass spectrometry. In general, the systems and methods described herein: (a) obtain an accurate mass spectrum of a sample; (b) calculate a unit mass spectrum based on the accurate mass spectrum; and (c) conduct a unit mass library search, based on the calculated unit masses, to obtain at least one candidate species to thereby identify the sample. The systems and methods may further: (d) calculate exact masses for each of a plurality of candidate species; and (e) eliminate candidate species due to ions that are outside a mass error window. The mass error window may be less than 500 ppm. The system and methods presented may be used in, for example, gas chromatrography mass spectrum and/or liquid chromatography mass spectrometry systems.
    Type: Application
    Filed: May 24, 2011
    Publication date: August 7, 2014
    Applicant: Agilent Technologies, Inc.
    Inventors: George E. Yefchak, Carl A. Myerholtz
  • Patent number: 8490466
    Abstract: The present invention includes a heat sealable capsule adapted for use in analysis devices such as GCs, and methods for using the capsules to perform analysis in such devices. The capsules include a tube having an end that is heat-sealed to contain a sample that is to be analyzed at an injection temperature. The tube includes a heat sealable medium having a heat seal that closes the end, the tube having an inner and outer surface, both of the surfaces being substantially chemically inert with respect to the sample. The tube is substantially free of any material that outgases at the injection temperature. The tube is openable without breaking into pieces, and remains intact at the injection temperature. The capsule can include a programmable tag that stores information related to the sample contained therein.
    Type: Grant
    Filed: December 20, 2009
    Date of Patent: July 23, 2013
    Assignee: Agilent Technologies, Inc.
    Inventors: Arthur Schleifer, Carl A. Myerholtz
  • Publication number: 20110146380
    Abstract: The present invention includes a heat sealable capsule adapted for use in analysis devices such as GCs, and methods for using the capsules to perform analysis in such devices. The capsules include a tube having an end that is heat-sealed to contain a sample that is to be analyzed at an injection temperature. The tube includes a heat sealable medium having a heat seal that closes the end, the tube having an inner and outer surface, both of the surfaces being substantially chemically inert with respect to the sample. The tube is substantially free of any material that outgases at the injection temperature. The tube is openable without breaking into pieces, and remains intact at the injection temperature. The capsule can include a programmable tag that stores information related to the sample contained therein.
    Type: Application
    Filed: December 20, 2009
    Publication date: June 23, 2011
    Inventors: Arthur Schleifer, Carl A. Myerholtz
  • Patent number: 7347921
    Abstract: The present invention provides an apparatus and method for threading a biopolymer through a nanopore. The apparatus of the present invention provides a substrate having a channel with a channel wall and a nanopore in the channel wall. The channel and nanopore are designed for receiving a biopolymer. The apparatus includes at least one set of electrodes for moving the biopolymer in a first direction past the nanopore, and at least one set of electrodes for moving the biopolymer through the nanopore in a second direction. The invention also provides a method for threading a biopolymer through a nanopore. The method includes moving the biopolymer past the nanopore in a first direction, and threading the biopolymer through the nanopore in a second direction.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: March 25, 2008
    Assignee: Agilent Technologies, Inc.
    Inventors: Phillip W. Barth, Carl A. Myerholtz
  • Patent number: 6497138
    Abstract: The present disclosure relates to a gas chromatograph having a plurality of layers or channels. The chromatograph typically comprises an inlet that receives a sample to be analyzed, a column disposed in each of the plurality of chromatograph layers, each column being in fluid communication with and downstream from the inlet and having a stationary phase coating its inner surfaces, and a detector in fluid communication with and downstream from at least one of the columns. In a preferred arrangement, the chromatograph includes a pre-column disposed in each of the chromatograph layers upstream of the columns, each pre-column being in fluid communication with the inlet and having a stationary phase coating its inner surfaces.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: December 24, 2002
    Assignee: Agilent Technologies, Inc.,
    Inventors: Mahmoud Farid Abdel-Rahman, Carl A. Myerholtz
  • Patent number: 6455845
    Abstract: A method of providing an ion packet to an analyzer section of a mass spectrometer from an ion beam, a pulser which can execute such a method, and a mass spectrometer which includes such a pulser. In the method, a field pulse is applied to extract an ion packet from the beam at a sideways direction to the beam and provide it to a mass analyzer section of the mass spectrometer, which pulse simultaneously causes non-extracted ions of the beam to be deflected onto an electrode of opposite charge. The pulse ON time is significantly longer than conventionally used. For example, the pulse ON time may be longer than the pulse OFF time or at least twice as long as or several times longer than required to extract the ion packet and provide it to the mass analyzer section, so as to reduce stray ions entering the mass analyzer section.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: September 24, 2002
    Assignee: Agilent Technologies, Inc.
    Inventors: Ganggiang Li, Carl A. Myerholtz, George Yefchak
  • Patent number: 6242735
    Abstract: A technique that modulates the power of a inductively coupled plasma (ICP) according to the operative modes of a spectrometer. An analytical apparatus of the present invention contains an inductively coupled plasma generator (ICPG) and a spectrometer. The ICPG generates a plasma for forming ionic and excited molecular species from a sample. The spectrometer analyzes the ionic and excited molecular species formed. The spectrometer operates in an analysis mode wherein the ionic and excited molecular species are identified according to physical characteristics of the species to provide data on the species and further has a washout mode wherein the spectrometer flushes out interfering ions and molecules and provides no significant data on the sample. The controller modulates the ICPG to operate in power cycles, at each cycle the ICPG operates in an analysis period and a stand-by period. By modulating the plasma power, the power consumption and heat dissipation can be reduced.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: June 5, 2001
    Assignee: Agilent Technologies, Inc.
    Inventors: Gangqiang Li, Thomas P. Doherty, Carl A. Myerholtz
  • Patent number: 6222186
    Abstract: A technique that modulates the power of a inductively coupled plasma (ICP) according to the operative modes of a spectrometer. An analytical apparatus of the present invention contains an inductively coupled plasma generator (ICPG) and a spectrometer. The ICPG generates a plasma for forming ionic and excited molecular species from a sample. The spectrometer analyzes the ionic and excited molecular species formed. The spectrometer operates in an analysis mode wherein the ionic and excited molecular species are identified according to physical characteristics of the species to provide data on the species and further has a washout mode wherein the spectrometer flushes out interfering ions and molecules and provides no significant data on the sample. The controller modulates the ICPG to operate in power cycles, at each cycle the ICPG operates in an analysis period and a stand-by period. By modulating the plasma power, the power consumption and heat dissipation can be reduced.
    Type: Grant
    Filed: June 25, 1998
    Date of Patent: April 24, 2001
    Assignee: Agilent Technologies, Inc.
    Inventors: Gangqiang Li, Thomas P. Doherty, Carl A. Myerholtz
  • Patent number: 5661300
    Abstract: A controlled gradient device acts as a reflectron that controls the velocity and direction of a charged particle stream when an external voltage source is applied. An enclosing insulating structure has a metallized contact ring on each end. The interior surface has a resistive coating to provide a continuous electrically resistive surface that generates a desired voltage gradient along the length when a voltage is applied across the metallized contact rings. Each of the metallized contact rings can be a metal mesh that is coincident with a cross-sectional region of the conduit so that the electrical potential is constant at these locations.
    Type: Grant
    Filed: September 17, 1996
    Date of Patent: August 26, 1997
    Assignee: Hewlett-Packard
    Inventors: Stuart C. Hansen, Carl A. Myerholtz
  • Patent number: 5598001
    Abstract: A multinotch filter for selectively removing target ions with a plurality of specific mass-to-charge ratios from an ion beam is disclosed. The multinotch filter uses a quadrupole and a power supply for generating rf voltages in the quadrupole. The quadrupole has two pairs of parallel electrodes. Each pair has two parallel, oppositely facing electrodes. The rf voltages generated by the power supply includes a rf quadrupole frequency component and at least a first excision frequency component and a second excision frequency component. The rf quadrupole frequency component is applied to the electrodes such that within each pair the two oppositely facing electrodes with respect to the rf quadrupole frequency component are equal in potential and the two pairs are 180.degree. out of phase. With respect to the first excision frequency component, the oppositely facing electrodes within one pair are 180.degree. out of phase with each other.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: January 28, 1997
    Assignee: Hewlett-Packard Company
    Inventors: Curt A. Flory, Carl A. Myerholtz
  • Patent number: 5462991
    Abstract: Disclosed are pH dyes containing a suitable compatible substituent which permits binding of the dye to a solid support. Also disclosed are methods for synthesizing such dyes prior to their coupling to the solid supports.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: October 31, 1995
    Inventors: Karla M. Robotti, Carl A. Myerholtz
  • Patent number: 5396065
    Abstract: A method and apparatus for analyzing ions by determining times of flight include establishing an encoded sequence for launching packets of ions from a source region toward a detector. The encoded sequence is one in which the high-mass ions of a leading packet will be passed by the low-mass ions of a trailing packet. Thus, a high efficiency time-of-flight mass spectrometer is formed. The ions of each packet are acted upon to bunch the ions of the packet, thereby compensating for initial space and/or velocity distributions of ions in the launching of the packet. The times of arrival of the ions are determined at the detector to obtain a signal of overlapping spectra corresponding to the overlapping launched packets. A correlation between the overlapping spectra and the encoded launch sequence is employed to derive a single non-overlapped spectrum.
    Type: Grant
    Filed: December 21, 1993
    Date of Patent: March 7, 1995
    Assignee: Hewlett-Packard Company
    Inventors: Carl A. Myerholtz, Richard L. Baer, Christian A. Le Cocq
  • Patent number: 5384411
    Abstract: Disclosed are pH dyes containing a suitable compatible substituent which permits binding of the dye to a solid support. Also disclosed are methods for synthesizing such dyes prior to their coupling to the solid supports.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: January 24, 1995
    Assignee: Hewlett-Packard Company
    Inventors: Karla M. Robotti, Carl A. Myerholtz
  • Patent number: 5306644
    Abstract: A system for accurate and precise measurements of analyte(s) in a system. The measurement system comprises piezoelectric surface wave sample devices, at least one piezoelectric surface wave reference device, and the measurement instrument.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: April 26, 1994
    Assignee: Hewlett-Packard Company
    Inventors: Carl A. Myerholtz, May Tom-Moy, Darlene J. Spira-Solomon, Richard L. Baer, Thomas P. Doherty
  • Patent number: 5229301
    Abstract: A mass biosensor method provides enhanced quantification of analyte concentrations in a sample. In a direct approach, an analyte is derivatized to form an analyte chelate and then specifically bound to a sensor. In an indirect approach, a complement of the analyte is derivatized to form a complement chelate which is then bound to a sensor. In a direct/indirect hybrid approach, an analog of the analyte is derivatized to form an analog chelate that is bound to a sensor in competition with the sample analyte. In all three approaches, mass measurements taken as the ligand chelate attaches to the sensor permit the concentration of the analyte in the sample to be calculated. Once measurement is completed, a dissociation treatment is applied to dissociate the derivatized species from the sensor so that the sensor can be reused. The effects of the dissociation treatment can be monitored using phosphorescence detection.
    Type: Grant
    Filed: June 7, 1991
    Date of Patent: July 20, 1993
    Assignee: Hewlett-Packard Company
    Inventors: Darlene J. Spira-Solomon, May Tom-Moy, Carl A. Myerholtz
  • Patent number: 5130631
    Abstract: In a multi-jointed robot, position controllers are located at each of the joints of the robot and are interconnected by a unitary bus. The bus carries a loosely-regulated voltage to all of the controllers and also includes data conductors connected to the controllers for disseminating position commands which are time-division multiplexed.
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: July 14, 1992
    Assignee: Hewlett-Packard Company
    Inventors: Gary B. Gordon, Carl A. Myerholtz
  • Patent number: 4855909
    Abstract: A forensic sample and tracking system includes a computer system which operates a data base and a read/write station. The assignment of an identifier in the data base and an identification code to be printed on a sample bottle label are coordinated by the computer. An identification code can then be read for verification after it is written. This permits automated verifying of identification codes in a heretofore unavailable manner. The read/write station makes use of an inexpensive, reliable and compact thermal ink jet print head so that a field computer and read/write station can be taken to sample collection sites. The effective linear resolution of the identification code is enhanced using a two-track bar code.
    Type: Grant
    Filed: November 20, 1987
    Date of Patent: August 8, 1989
    Assignee: Hewlett-Packard Company
    Inventors: Kent D. Vincent, Carl A. Myerholtz
  • Patent number: 4333336
    Abstract: Disclosed is a method and device for automatically and instantaneously computing and displaying with high precision the flow rate of thermoplastic samples run in an extrusion plastometer in accordance with American Society of Testing Materials (ASTM) Method D1238. The method and device comprise using a microcomputer and related circuitry to monitor and control the measurement process and subsequently compute the resulting flow rate.
    Type: Grant
    Filed: May 7, 1980
    Date of Patent: June 8, 1982
    Assignee: Standard Oil Company (Indiana)
    Inventors: Carl A. Myerholtz, Ralph W. Myerholtz, Jr.