Patents by Inventor Carl Atkinson

Carl Atkinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250222127
    Abstract: Described herein are compositions and methods for treating or preventing an injury associated with transplant. Specifically, the disclosure provides a composition for treating or preventing an injury associated with transplantation, comprising (a) a targeted inhibitor molecule wherein the targeted inhibitor molecule comprises a targeting portion and an inhibitor portion, wherein the molecule inhibits complement pathways, and (b) a sub-therapeutic dose of an immunosuppressant agent. Further provided are methods of treating or preventing an injury associated with transplantation with activated complement by using the compositions.
    Type: Application
    Filed: September 13, 2024
    Publication date: July 10, 2025
    Applicants: MUSC Foundation For Research Development, United States Government as Represented by the Department of Veteran Affairs
    Inventors: Stephen Tomlinson, Carl Atkinson, Xue-Zhong Yu
  • Patent number: 11344025
    Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation and for inducing mitochondrial morphological alterations.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: May 31, 2022
    Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Satish N. Nadig, Carl Atkinson, Danh T. Tran
  • Patent number: 11260027
    Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: March 1, 2022
    Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Satish Nadig, Carl Atkinson, Ann-Marie Broome, Suraj K. Dixit
  • Patent number: 11214805
    Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: January 4, 2022
    Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Ann-Marie Broome, Suraj Dixit, Satish Nadig, Carl Atkinson
  • Publication number: 20210388080
    Abstract: The present invention provides targeted delivery methods and constructs for treating inflammatory diseases and/or detecting in vivo tissue injuries in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The invention also provides methods of inhibiting complement-driven inflammation in the eye in an individual, comprising administering to the individual an antibody or a fragment thereor or compositions thereof, wherein the antibody or fragment thereof specifically binds to Annexin IV or phospholipid. Also provided are related methods of treating a complement-associated ocular disease or an ocular disease involving oxidative damage.
    Type: Application
    Filed: April 12, 2021
    Publication date: December 16, 2021
    Inventors: Baerbel M. Rohrer, V. Michael Holers, Stephen Tomlinson, Joshua M. Thurman, Carl Atkinson, Liudmila Kulik
  • Publication number: 20200281190
    Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation and for inducing mitochondrial morphological alterations.
    Type: Application
    Filed: December 26, 2018
    Publication date: September 10, 2020
    Inventors: Satish N. Nadig, Carl Atkinson, Danh T. Tran
  • Publication number: 20200056183
    Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.
    Type: Application
    Filed: August 23, 2019
    Publication date: February 20, 2020
    Inventors: Ann-Marie Broome, Suraj Dixit, Satish Nadig, Carl Atkinson
  • Patent number: 10428331
    Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: October 1, 2019
    Assignee: MUSC Foundation for Research Development
    Inventors: Ann-Marie Broome, Suraj Dixit, Satish Nadig, Carl Atkinson
  • Publication number: 20190247511
    Abstract: Described herein are compositions and methods for treating or preventing an injury associated with transplant. Specifically, the disclosure provides a composition for treating or preventing an injury associated with transplantation, comprising (a) a targeted inhibitor molecule wherein the targeted inhibitor molecule comprises a targeting portion and an inhibitor portion, wherein the molecule inhibits complement pathways, and (b) a sub-therapeutic dose of an immunosuppressant agent. Further provided are methods of treating or preventing an injury associated with transplantation with activated complement by using the compositions.
    Type: Application
    Filed: October 17, 2017
    Publication date: August 15, 2019
    Inventors: Stephen TOMLINSON, Carl ATKINSON, Xue-Zhong YU
  • Publication number: 20180338963
    Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.
    Type: Application
    Filed: June 24, 2016
    Publication date: November 29, 2018
    Inventors: Satish NADIG, Carl ATKINSON, Ann-Marie BROOME, Suraj K. DIXIT
  • Publication number: 20160317670
    Abstract: Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 3, 2016
    Inventors: Ann-Marie Broome, Suraj Dixit, Satish Nadig, Carl Atkinson
  • Publication number: 20160083469
    Abstract: The present invention provides targeted delivery methods and constructs for treating inflammatory diseases and/or detecting in vivo tissue injuries in an individual. The targeted delivery approach utilizes an antibody that recognises an epitope found to be present at sites of inflammation. The invention also provides methods of inhibiting complement-driven inflammation in the eye in an individual, comprising administering to the individual an antibody or a fragment thereof or compositions thereof, wherein the antibody or fragment thereof specifically binds to Annexin IV or phospholipid. Also provided are related methods of treating a complement-associated ocular disease or an ocular disease involving oxidative damage.
    Type: Application
    Filed: July 23, 2015
    Publication date: March 24, 2016
    Inventors: Baerbel M. Rohrer, Michael Holers, Stephen Tomlinson, Joshua M. Thurman, Carl Atkinson, Liudmila Kulik
  • Patent number: 9066925
    Abstract: Provided herein are methods and compositions, including pharmaceutical compositions, for stimulating liver regeneration after partial hepatectomy, massive liver resection and toxic injury, or following liver transplantation, including small-for-size liver transplantation, by inhibiting activation of complement.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: June 30, 2015
    Assignee: MUSC Foundation for Research Development
    Inventors: Stephen Tomlinson, Songqing He, Carl Atkinson
  • Publication number: 20120171206
    Abstract: Provided herein are methods and compositions, including pharmaceutical compositions, for stimulating liver regeneration after partial hepatectomy, massive liver resection and toxic injury, or following liver transplantation, including small-for-size liver transplantation, by inhibiting activation of complement.
    Type: Application
    Filed: July 2, 2010
    Publication date: July 5, 2012
    Inventors: Stephen Tomlinson, Songqing He, Carl Atkinson
  • Patent number: 4118061
    Abstract: A vehicle seat assembly having adaptability for use as both a side facing seat positioned along the side walls of various model vehicles and as a front facing seat along the rear wall of various model vehicles. The assembly has a plurality of seat modules, the combination being any mix of the single occupant or double occupant variety. Each of the seat modules has a shell-like structure with a back portion and a seat portion, both of which have a concave outer contour configured to receive a human body. Side flanges are integrally formed along the edges of the seat and back portions. A plurality of end arm members are provided and each has a panel section and inwardly extending flanges for supportably contacting the side flanges of the seat module. The arm member flanges have a back portion support flange and a seat portion support flange. Interlocking structure is formed on the rear of the end arm members for engaging interlocking structure on the front of seat mounting adaptor members.
    Type: Grant
    Filed: July 25, 1977
    Date of Patent: October 3, 1978
    Assignee: Rohr Industries, Inc.
    Inventors: Thomas Carl Atkinson, Clifford C. Fay