Abstract: Disclosed herein are endotracheal tubes that have multiple inflatable cuffs to help form a seal for ventilation, to reduce unwanted migration of the tube relative to the patient, reduce focalized pressure from a single cuff, and to help prevent aspiration of materials between the outside of the tube and the tracheal walls. Some devices include first and second distal cuffs for placement within the trachea and a proximal third cuff for blocking the entrance to the trachea. The cuffs can include ridges or textures to enhance sealing. The device can also include inflation channels, vacuum channels, and pressure sensors.

Abstract: Dynamic allocation of power modules for charging electric vehicles is described herein. A power cabinet includes multiple power modules that each are capable of supplying an amount of power to a dispenser. Multiple dispensers are coupled with the same power cabinet. A first power bus couples a first dispenser and switchably connects the power modules to the first dispenser; and a second power bus couples a second dispenser and switchably connects the power modules to the second dispenser. The power cabinet includes a control unit that is configured to cause the power modules to switchably connect and disconnect from the first power bus and the second power bus to dynamically allocate the power modules between the first dispenser and the second dispenser.

Abstract: The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof.

Abstract: The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof.

Abstract: This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.

Abstract: This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.

Abstract: The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof.

Abstract: A first aspect of the present invention describes a compound selected from group consisting of: wherein R is either H, C(O)RA, or C(O)NHCH(X)COOH; provided that X is a C2-C6 alkyl, or a C3-C8 cycloalkyl and RA is a C1-6 alkyl or aryl; These compounds are used to make Compound A

Abstract: The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity.

Abstract: The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof.

Abstract: A centralizer system is provided for use in a marine riser system to provide a stress joint or keel joint with a upset portion. The centralizer is preferably heat-shrink fitted to the upset portion of the keel joint. The upset portion has tapered sections on the upper and lower ends which may be of various shapes and lengths that gradually blend into the outer diameter of the pipe used as the keel joint. The centralizer may also be heat-shrink fitted to one of the tapered sections. The centralizer may or may not utilize guide sections mounted on either end thereof. In a preferred embodiment, the centralizer comprises axially extending annular grooves in surrounding relationship to the upset portion, the grooves serving to permit forces acting on the centralizer to be redirected or dissipated to thereby prevent excessive buildup on a selected region of the upset portion adjacent the radial grooves.

Abstract: A centralizer system is provided for use in a marine riser system with an insulated pipe, which may be a titanium stress joint. The centralizer system utilizes one or more centralizers mounted such that insulation material is provided in an annulus between the one or more centralizers and the stress joint. A clamp is utilized to axially affix either one centralizer or multiple centralizers to the stress joint. The clamp is comprised of a plurality of sections with cylindrical interior surfaces which are tightened together using fasteners. The cylindrical interior surfaces avoid damage to the insulation layer which may be elastomeric. The clamp and each centralizer have radially directed projections thereon which interlock the clamp with each centralizer. Because the clamp is axially affixed, the centralizer is then also axially affixed. In one embodiment, the centralizer is axially moveable to a desired axial position prior to being interlocked to the tightened clamp.