Patents by Inventor Carl Borrebaeck

Carl Borrebaeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210181195
    Abstract: The present invention provides methods for detecting and/or quantifying one or more biomarker(s) in a biological sample, as well as conjugates and systems for use in that method. The present invention also provides associated kits and methods of diagnosis and/or prognosis of disease, based on the principles of the methods for detecting and/or quantifying one or more biomarker(s).
    Type: Application
    Filed: January 29, 2019
    Publication date: June 17, 2021
    Inventors: Carl Borrebaeck, Mattias Brofelth, Anna Isinger Ekstrand, Christer Wingren
  • Publication number: 20200057061
    Abstract: The invention provides a method for determining a systemic lupus erythematosus-associated disease state in a subject comprising the steps of (a) providing a sample to be tested; and (b) measuring the presence and/or amount in the test sample of one or more biomarker(s) selected from the group defined in Table A, wherein the presence and/or amount in the test sample of the one or more biomarker(s) selected from the group defined in Table A is indicative of a systemic lupus. The invention also provides an array and a kit suitable for use in the methods of the invention.
    Type: Application
    Filed: June 7, 2017
    Publication date: February 20, 2020
    Inventors: Carl BORREBAECK, Payam DELFANI, Linda Dexlin MELLBY, Christer WINGREN
  • Publication number: 20200041504
    Abstract: The invention provides a method for determining a systemic lupus erythematosus-associated disease state in a subject comprising the steps of (a) providing a sample to be tested; and (b) measuring the presence and/or amount in the test sample of one or more biomarker(s) selected from the group defined in Table A, wherein the presence and/or amount in the test sample of the one or more biomarker(s) selected from the group defined in Table A is indicative of a systemic Lupus-associated disease state. The invention also provides an array and a kit suitable for use in the methods of the invention.
    Type: Application
    Filed: June 7, 2017
    Publication date: February 6, 2020
    Inventors: Carl BORREBAECK, Payam DELFANI, Linda Dexlin MELLBY, Christer WINGREN
  • Publication number: 20200011872
    Abstract: The present invention provides a method for diagnosing or determining a pancreatic cancer-associated disease state comprising or consisting of the steps of: (a) providing a sample from an individual to be tested; and (b) determining a biomarker signature of the test sample by measuring the presence and/or amount in the test sample of one or more biomarker selected from the group defined in Table A; wherein the presence and/or amount in the test sample of the one or more biomarker selected from the group defined in Table A is indicative of the pancreatic cancer associated disease in the individual; uses and methods of determining a pancreatic cancer-associated disease state, and methods of treating pancreatic cancer, together with arrays and kits for use in the same.
    Type: Application
    Filed: May 10, 2017
    Publication date: January 9, 2020
    Inventors: Carl BORREBAECK, Anna Sandström GERDTSSON, Christer WINGREN
  • Publication number: 20190382849
    Abstract: The present invention provides a method for diagnosing or determining a pancreatic cancer-associated disease state comprising or consisting of the steps of: (a) providing a sample from an individual to be tested; and (b) determining a biomarker signature of the test sample by measuring the presence and/or amount in the test sample of one or more biomarker selected from the group defined in Table A; wherein the presence and/or amount in the test sample of the one or more biomarker selected from the group defined in Table A is indicative of the pancreatic cancer associated disease in the individual; uses and methods of determining a pancreatic cancer-associated disease state, and methods of treating pancreatic cancer, together with arrays and kits for use in the same.
    Type: Application
    Filed: January 31, 2018
    Publication date: December 19, 2019
    Inventors: Carl Borrebaeck, Linda Dexlin Mellby, Andreas Nyberg, Christer Wingren
  • Publication number: 20170283874
    Abstract: The present invention relates to an in vitro method for identifying agents capable of inducing respiratory sensitization in a mammal and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in Table 1A, Table 1B and/or Table 1C in MUTZ-3 cells exposed to a test agent.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Inventors: Malin Lindstedt, Carl Borrebaeck, Henrik Johansson, Ann-Sofie Albrekt
  • Publication number: 20150111771
    Abstract: The present invention relates to an in vitro method for identifying agents capable of inducing respiratory sensitization in a mammal and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in Table 1A, Table 1B and/or Table 1C in MUTZ-3 cells exposed to a test agent.
    Type: Application
    Filed: April 26, 2013
    Publication date: April 23, 2015
    Inventors: Malin Lindstedt, Carl Borrebaeck, Henrik Johansson, Ann-Sofie Albrekt
  • Patent number: 7816085
    Abstract: The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; c) contacting the fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3? and 5? ends of at least one of the parent polynucleotides under annealing conditions; and d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by the parent polynucleotides.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: October 19, 2010
    Assignee: Alligator Bioscience AB
    Inventors: Roland Carlsson, Ann-Christin Malmborg Hager, Christina Furebring, Carl Borrebaeck
  • Publication number: 20090285750
    Abstract: The present application relates to agents, compositions and methods for use in medicine. In particular, the application relates to an agent comprising a binding moiety capable of selectively binding to Ku protein for use in medicine, in particular in the treatment and diagnosis of cancers.
    Type: Application
    Filed: April 11, 2007
    Publication date: November 19, 2009
    Inventors: Carl Borrebaeck, Johan Fransson
  • Publication number: 20090280526
    Abstract: The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3? and 5? ends of at least one of the parent polynucleotides under annealing conditions; d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
    Type: Application
    Filed: July 16, 2009
    Publication date: November 12, 2009
    Inventors: Roland Carlsson, Ann-Christin Malmborg Hager, Christina Furebring, Carl Borrebaeck
  • Patent number: 7563578
    Abstract: The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3? and 5? ends of at least one of the parent polynucleotides under annealing conditions; d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: July 21, 2009
    Assignee: Alligator Bioscience AB
    Inventors: Roland Carlsson, Ann-Christin Malmborg Hager, Christina Furebring, Carl Borrebaeck
  • Publication number: 20080248533
    Abstract: The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3? and 5? ends of at least one of the parent polynucleotides under annealing conditions; d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
    Type: Application
    Filed: September 20, 2007
    Publication date: October 9, 2008
    Inventors: Roland Carlsson, Ann-Christin Malmborg Hager, Christina Furebring, Carl Borrebaeck
  • Patent number: 7282334
    Abstract: The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3? and 5? ends of at least one of the parent polynucleotides under annealing conditions; d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: October 16, 2007
    Assignee: Alligator Bioscience, AB
    Inventors: Roland Carlsson, Ann-Christin Malmborg Hager, Christina Furebring, Carl Borrebaeck
  • Publication number: 20060166198
    Abstract: A method for in vitro molecular evolution of protein function The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single-stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of (a) providing a first population of single-stranded polynucleotide molecules and a second population of single-stranded polynucleotide molecules, the first and second populations together constituting plus and minus strands of parent polynucleotide sequences, (b) carrying out a reaction for digesting the first and second populations of single-stranded polynucleotide molecules with an exonuclease to generate corresponding populations of single-stranded polynucleotide fragments, (c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3? and 5?ends of at least one of the parent polynucleotides under annealing conditions, and (d) a
    Type: Application
    Filed: May 16, 2003
    Publication date: July 27, 2006
    Applicant: Alligator Bioscience AB
    Inventors: Christina Furebring, Roland Carlsson, Carl Borrebaeck, Ann-Christin Malmborg Hager
  • Publication number: 20060019300
    Abstract: The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3? and 5? ends of at least one of the parent polynucleotides under annealing conditions; d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
    Type: Application
    Filed: July 20, 2005
    Publication date: January 26, 2006
    Inventors: Roland Carlsson, Ann-Christin Hager, Christina Furebring, Carl Borrebaeck
  • Publication number: 20050266451
    Abstract: The present invention relates to a method for in vitro creation of molecular libraries evolution of protein function. Particularly, it relates to variability and modification of protein function by shuffling polynucleotide sequence segments. A protein of desired characteristics can be obtained by incorporating variant peptide regions (variant motifs) into defined peptide regions (scaffold sequence). The variant motifs can be obtained from parent DNA which has been subjected to mutagenesis to create a plurality of differently mutated derivatives thereof or they can be obtained from in vivo sequences. These variant motifs can then be incorporated into a scaffold sequence and the resulting coded protein screened for desired characteristics. This method is ideally used for obtaining antibodies with desired characteristics by isolating individual CDR DNA sequences and incorporating them into a scaffold which may, for example, be from a totally different antibody.
    Type: Application
    Filed: April 19, 2005
    Publication date: December 1, 2005
    Inventors: Ulf Soderlind, Carl Borrebaeck
  • Patent number: 6958213
    Abstract: The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of (a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; (b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; (c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3? and 5? ends of at least one of the parent polynucleotides under annealing conditions; (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: October 25, 2005
    Assignee: Alligator Bioscience AB
    Inventors: Roland Carlsson, Ann-Christin Malmborg Hager, Christina Furebring, Carl Borrebaeck
  • Publication number: 20030224410
    Abstract: A method for selecting nucleic acid sequences encoding ligand and receptor molecules capable of specific binding to each other is disclosed in which nucleic acid encoding ligand or receptor molecules is expressed in a host microorganism in combination with a surface molecule, such as E. coli pili, so that the ligand or receptor are displayed on the surface of the host microorganism. A replicable genetic unit, such as a filamentous bacteriophage, is used to display candidate binding partners to the ligand or receptor, with the binding of the ligand or receptor to the candidate binding partner mediating the transfer of nucleic acid from the replicable genetic unit to the microorganism. The method can be highly selective as the host microorganism is modified so that it does not display the surface molecule other than as a fusion with the ligand receptor molecule. The method is rapid and simple and opens up new applications based on the detection of ligand and receptors where both are unknown.
    Type: Application
    Filed: March 13, 2003
    Publication date: December 4, 2003
    Inventors: Carl Borrebaeck, Anki Malmborg, Eskil Soderlind
  • Patent number: 6607881
    Abstract: A method for selecting nucleic acid sequences encoding ligand and receptor molecules capable of specific binding to each other is disclosed in which nucleic acid encoding ligand or receptor molecules is expressed in a host microorganism in combination with a surface molecule, such as E. coli pili, so that the ligand or receptor are displayed on the surface of the host microorganism. A replicable genetic unit, such as a filamentous bacteriophage, is used to display candidate binding partners to the ligand or receptor, with the binding of the ligand or receptor to the candidate binding partner mediating the transfer of nucleic acid from the replicable genetic unit to the microorganism. The method can be highly selective as the host microorganism is modified so that it does not display the surface molecule other than as a fusion with the ligand or receptor molecule. The method is rapid and simple and opens up new applications based on the detection of ligand and receptors where both are unknown.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: August 19, 2003
    Assignee: Bioinvent International, AB
    Inventors: Carl Borrebaeck, Anki Malmborg, Eskil Söderlind
  • Publication number: 20020146780
    Abstract: The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of
    Type: Application
    Filed: December 12, 2000
    Publication date: October 10, 2002
    Inventors: Roland Carlsson, Ann-Christin Malmborg Hager, Christina Furebring, Carl Borrebaeck