Abstract: A method to produce novel split-protein sensors are described herein. The method implements a sequence dissimilarity (SD) based design that can identify potential split-sites in proteins to generate a split-protein pair, and then employs structure guided mutagenesis of the fragmented protein interface to generate split-protein sensors. The sensors have a signal to background ratio >200 and can be readily used to monitor protein-protein interactions and their inhibition in cells.

Abstract: A personnel monitoring system. The personnel monitoring system includes a host node having an optical source for generating optical signals, and an optical receiver. The personnel monitoring system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node.

Abstract: A personnel monitoring system. The personnel monitoring system includes a host node having an optical source for generating optical signals, and an optical receiver. The personnel monitoring system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node.

Abstract: A personnel monitoring system. The personnel monitoring system includes a host node having an optical source for generating optical signals, and an optical receiver. The personnel monitoring system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node.

Abstract: A light powered communications system. The light powered communications system includes an audio control center having at least one optical source and at least one optical receiver. The light powered communications system also includes a plurality of optically powered remote communication systems located remote from the audio control center, each of the optically powered remote communication systems being configured to receive an optical signal from the audio control center. The light powered communication system also includes at least one length of fiber optic cable between the audio control center and each of the optically powered remote communication systems.

Abstract: A personnel monitoring system. The personnel monitoring system includes a host node having an optical source for generating optical signals, and an optical receiver. The personnel monitoring system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node.

Abstract: A personnel monitoring system. The personnel monitoring system includes a host node having an optical source for generating optical signals, and an optical receiver. The personnel monitoring system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node.

Abstract: A light powered communications system. The light powered communications system includes an audio control center having at least one optical source and at least one optical receiver. The light powered communications system also includes a plurality of optically powered remote communication systems located remote from the audio control center, each of the optically powered remote communication systems being configured to receive an optical signal from the audio control center. The light powered communication system also includes at least one length of fiber optic cable between the audio control center and each of the optically powered remote communication systems.

Abstract: A personnel monitoring system. The personnel monitoring system includes a host node having an optical source for generating optical signals, and an optical receiver. The personnel monitoring system also includes a plurality of fiber optic sensors for converting at least one of vibrational and acoustical energy to optical intensity information, each of the fiber optic sensors having: (1) at least one length of optical fiber configured to sense at least one of vibrational and acoustical energy; (2) a reflector at an end of the at least one length of optical fiber; and (3) a field node for receiving optical signals from the host node, the field node transmitting optical signals along the at least one length of optical fiber, receiving optical signals back from the at least one length of optical fiber, and transmitting optical signals to the optical receiver of the host node.