Patents by Inventor Carl CO

Carl CO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins
    Patent number: 11340225
    Abstract: The present disclosure provides methods of assaying for antibody-dependent cell-mediated phagocytosis (ADCP). In some embodiments, the methods include monomerizing and labeling a protein, contacting the protein with a protein-specific antibody to form an antibody-protein complex, contacting the antibody-protein complex with a phagocytic cell to permit phagocytosis, and assessing the amount of internalized fluorescence.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: May 24, 2022
    Assignee: Biogen International Neuroscience GmbH
    Inventors: Carl Co, Allyson Masci, Svetlana Bergelson
  • ANTIBODY-DEPENDENT CELL-MEDIATED PHAGOCYTOSIS ASSAY FOR RELIABLY MEASURING UPTAKE OF AGGREGATED PROTEINS
    Publication number: 20190079077
    Abstract: The present disclosure provides methods of assaying for antibody-dependent cell-mediated phagocytosis (ADCP). In some embodiments, the methods include monomerizing and labeling a protein, contacting the protein with a protein-specific antibody to form an antibody-protein complex, contacting the antibody-protein complex with a phagocytic cell to permit phagocytosis, and assessing the amount of internalized fluorescence.
    Type: Application
    Filed: March 14, 2017
    Publication date: March 14, 2019
    Inventors: Carl Co, Allyson Masci, Svetlana Bergelson
  • CONJUGATION METHODS FOR MODIFYING OR IMMOBILIZING PROTEINS
    Publication number: 20180319838
    Abstract: The present disclosure relates, in some aspects, to protein-ligand localized conjugation technology with respect to immobilized functional proteins for affinity enrichment and/or modified proteins for therapeutic applications.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 8, 2018
    Applicant: Biogen MA Inc.
    Inventors: Carl CO, John E. COUGHLIN