Abstract: Apparatuses, computer-readable mediums, and methods are provided. In one embodiment, a positron emission tomography (“PET”) detector array is provided which includes a plurality of crystal elements arranged in a two-dimensional checkerboard configuration. In addition, there are empty spaces in the checkerboard configuration. In various embodiments, the empty spaces are filled with passive shielding, transmission source assemblies, biopsy instruments, surgical instruments, and/or electromagnetic sensors. In various embodiments, the crystal elements and the transmission source assemblies simultaneously perform emission/transmission acquisitions.

Abstract: The use of the effect of crystallographic axis orientation on the effectiveness in annealing in multiple atmospheres and chemical compositions of lutetium oxyorthosilicate crystals and other scintillator crystals is disclosed. By controlling axis orientation an favorable annealing condition can be selected to repair both internal interstitial and vacancy defects through the crystal lattice. Axis orientation can be further utilized to control the uniformity of surface finish of chemically etched crystal.

Abstract: A halide material, such as scintillator crystals of LaBr3:Ce and SrI2:Eu, with a passivation surface layer is disclosed. The surface layer comprises one or more halides of lower water solubility than the scintillator crystal that the surface layer covers. A method for making such a material is also disclosed. In certain aspects of the disclosure, a passivation layer is formed on a surface of a halide material such as a scintillator crystal of LaBr3:Ce of SrI2:Eu by fluorinating the surface with a fluorinating agent, such as F2 for LaBr3:Ce and HF for SrI2:Eu.

Abstract: A method and device for improving the optical performance (such as time resolution) of scintillation detectors using the optical bleaching technique are disclosed. Light of a selected wavelength is emitted by a light source into a scintillator. The wavelength is selected to meet the minimum energy requirement for releasing of charge carriers captured by the charge carrier traps in the scintillation material. Trap-mediated scintillation components are thus reduced by optical bleaching and the optical performance of the scintillator crystal and the detector is enhanced.

Abstract: A mixed halide scintillator material including a fluoride is disclosed. The introduction of fluorine reduces the hygroscopicity of halide scintillator materials and facilitates tuning of scintillation properties of the materials.

Abstract: The invention provides compositions, methods and devices for noninvasive measurement of the analyte levels in vivo. More specifically, the invention provides a hand-held glucose monitor and an optical coupler that allows for short-term discontinuous and/or continuous information on dynamic in vivo glucose levels. The device may include a optical coupler for optically connecting a skin surface to the device that contains a plurality of zones. These zones contain areas for a variety of purposes including calibration of the instrument, reading of the skin surface, and protection of the instrument.