Patents by Inventor Carl Dambkowski

Carl Dambkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250009748
    Abstract: The present disclosure provides a method of treating cancer in a subject. The method including administering to the subject: a) a therapeutically effective amount of a compound of formula (I); and b) a therapeutically effective amount of sotorasib, wherein the compound of formula (I) is represented by (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, conformational isomer, tautomer, or a combination thereof. In particular, the present disclosure provides a method of treating a solid tumor (e.g., an advanced or metastatic non-small cell lung cancer) with a therapeutically effective amount of a compound of formula (10b) (i.e., 6-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(Ra)-(2,3-dichlorophenyl)-2,5-dimethylpyrimidin-4(3H)-one) in combination with sotorasib in a subject, wherein the subject has one or more mutations in KRAS, such as KRAS G12C.
    Type: Application
    Filed: September 30, 2022
    Publication date: January 9, 2025
    Inventors: Pedro BELTRAN, Carl DAMBKOWSKI, Justin LIM, Anna WADE, Eli WALLACE, Yuting SUN, Nancy KOHL, Brooke MEYERS, Kerstin SINKEVICIUS, James STICE, David VAN VEENHUYZEN, Lauren WOOD
  • Publication number: 20240009193
    Abstract: Provided herein are methods of treating a skeletal dysplasia such as hypochondroplasia or achondroplasia in a pediatric patient by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof. Also provided are minitablets including infigratinib monophosphate and a pharmaceutically acceptable excipient for use in treating a skeletal dysplasia such as hypochondroplasia or achondroplasia in pediatric patients.
    Type: Application
    Filed: December 17, 2021
    Publication date: January 11, 2024
    Inventors: Riccardo Panicucci, Susan Arangio, Carl Dambkowski, Michael Henderson, Daniela Rogoff, Michael Monteith, Lihua Zhang
  • Publication number: 20220233537
    Abstract: Provided herein are methods of treating an upper tract urothelial carcinoma in a patient by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof. Also provided herein are methods of treating non-muscle invasive bladder cancer by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 29, 2020
    Publication date: July 28, 2022
    Inventors: Riccardo Panicucci, Susan Arangio, Craig Berman, Michael Monteith, Harris Soifer, Gang Li, Carl Dambkowski, Daniel Mulreany
  • Publication number: 20220233536
    Abstract: Provided herein are methods of treating advanced or metastatic cholangiocarcinoma in a patient by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof, wherein the patient has progression of the cholangiocarcinoma after previous administration of another therapy.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 28, 2022
    Inventors: Riccardo Panicucci, Michael Monteith, Gang Li, Susan Arangio, Craig Berman, Michael Howland, Daniel Mulreany, Carl Dambkowski