Patents by Inventor Carl F. Perez

Carl F. Perez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Infective protein delivery system
    Patent number: 6071512
    Abstract: A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: June 6, 2000
    Assignee: Chiron Corporation
    Inventors: Michael Kriegler, Carl F. Perez
  • TNF deletion muteins
    Patent number: 5889156
    Abstract: A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: March 30, 1999
    Assignee: Chiron Corporation
    Inventors: Michael Kriegler, Carl F. Perez
  • Recombinant host cells encoding TNF proteins
    Patent number: 5888814
    Abstract: A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: March 30, 1999
    Assignee: Chiron Corporation
    Inventors: Michael Kriegler, Carl F. Perez
  • Human til cells expressing recombinant TNF prohormone
    Patent number: 5874077
    Abstract: Tumor Infiltrating Lymphocyte (TIL) cells transformed with exogenous DNA encoding tumor necrosis factor (TNF) prohormone variants are disclosed. Among such variants are the TNF .gamma. sig construct, which facilitates expression of the mature TNF polypeptide, and the noncleavable cytotoxic prohormone variants TNF.DELTA.(1.fwdarw.12) and TNF(1+12). The transformed TIL cells are useful in antitumor therapy.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: February 23, 1999
    Assignee: Chiron Corporation
    Inventors: Michael Kriegler, Carl F. Perez
  • Gene fusion encoding a hypersecretor protein
    Patent number: 5863797
    Abstract: A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: January 26, 1999
    Assignee: Chiron Corporation
    Inventors: Michael Kriegler, Carl F. Perez
  • Infective protein delivery system
    Patent number: 5849586
    Abstract: A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 15, 1998
    Assignee: Chiron Corporation
    Inventors: Michael Kriegler, Carl F. Perez