Patents by Inventor Carl Frasch

Carl Frasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polysaccharide-protein conjugate vaccines
    Publication number: 20070141084
    Abstract: Abstract of the Disclosure Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
    Type: Application
    Filed: August 6, 2004
    Publication date: June 21, 2007
    Inventors: Che-Hung Lee, Carl Frasch
  • Process for preparing polysaccharide-protein conjugate vaccines
    Publication number: 20070110762
    Abstract: Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
    Type: Application
    Filed: August 6, 2004
    Publication date: May 17, 2007
    Applicant: Department Of Health And Human Services, Govt. of the United States of America
    Inventors: Ellen Jessouroun, Ivna Brasileiro Da Silveira, Renata Bastos, Carl Frasch, Che-Hung Lee
  • Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
    Patent number: 4601903
    Abstract: The present invention discloses a vaccine against Neisseria meningitidis Group B, serotype 2b strain. More particularly, the present invention is related to an aluminum hydroxide adjuvanted vaccine containing only a single serotype 2 antigen being protective against both 2a and 2b meningococcal disease.
    Type: Grant
    Filed: May 1, 1985
    Date of Patent: July 22, 1986
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Carl Frasch