Abstract: A method is provided for operating a working machine having a device for conveying thick material. A number of target values relating to the operation of the device for conveying thick material can be adjusted by a user. The method includes the following steps: detecting a number of actual values of the device; calculating a target value optimum for a respective target value of the number of adjustable target values based on the number of detected actual values; and outputting a notification for the user, in the event that an adjusted target value of the number of adjustable target values does not correspond to its calculated target value optimum.

Abstract: Abstract of the Disclosure Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.

Abstract: Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.

Abstract: The present invention discloses a vaccine against Neisseria meningitidis Group B, serotype 2b strain. More particularly, the present invention is related to an aluminum hydroxide adjuvanted vaccine containing only a single serotype 2 antigen being protective against both 2a and 2b meningococcal disease.