Patents by Inventor Carl Fuller

Carl Fuller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10246533
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of monomer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: April 2, 2019
    Assignees: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES Corporation
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofslokken Kjus, Astrid Evenroed Molteberg, Diem Tran, Jo Aaserud, M. Talha Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Patent number: 10202473
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: February 12, 2019
    Assignees: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATION
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofsloekken Kjus, Astrid Evenroed Molteberg, Diem Thuy Thi Tran, Jo Aaserud, M. Talha Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Publication number: 20180135121
    Abstract: The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as ?-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming conjugates in nanopore devices and methods.
    Type: Application
    Filed: January 11, 2018
    Publication date: May 17, 2018
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Zengmin Li, Sergey Kalachikov, Carl Fuller
  • Patent number: 9890426
    Abstract: The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as ?-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: February 13, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Zengmin Li, Sergey Kalachikov, Carl Fuller
  • Publication number: 20170175183
    Abstract: The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as ?-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.
    Type: Application
    Filed: February 22, 2017
    Publication date: June 22, 2017
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Zengmin Li, Sergey Kalachikov, Carl Fuller
  • Patent number: 9487603
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: November 8, 2016
    Assignees: LIfe Technologies Corporation, Life Technologies AS
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofslokken Kjus, Astrid Evenroed Molteberg, Diem Tran, Jo Aaserud, M. Talha Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Publication number: 20160137762
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: January 25, 2016
    Publication date: May 19, 2016
    Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofsloekken KJUS, Astrid Evenroed MOLTEBERG, Diem Thuy Thi TRAN, Jo AASERUD, M. Talha GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Publication number: 20160097094
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: December 15, 2015
    Publication date: April 7, 2016
    Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofslokken KJUS, Astrid Evenroed MOLTEBERG, Diem TRAN, Jo AASERUD, Talha M. GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Publication number: 20160097095
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: December 15, 2015
    Publication date: April 7, 2016
    Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofslokken KJUS, Astrid Evenroed MOLTEBERG, Diem TRAN, Jo AASERUD, Talha M. GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Patent number: 9243085
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: January 26, 2016
    Assignees: Life Technologies Corporation, Life Technologies AS
    Inventors: Geir Fonnum, Grete Modahl, Nini Kjus, Astrid Evenroed Molteberg, Diem Tran, Jo Aaserud, M. Talha Gokmen, Steven Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Patent number: 9156925
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: October 13, 2015
    Assignee: Life Technologies Corporation
    Inventors: Geir Fonnum, Grete I. Modahl, Nini H. Kjus, Astrid E. Molteberg, Diem Tran, Jo Aaserud, Talha M. Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Patent number: 9139666
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: September 22, 2015
    Assignees: Life Technologies Corporation, Life Technologies AS
    Inventors: Geir Fonnum, Grete I. Modahl, Nini H. Kjus, Astrid E. Molteberg, Diem Tran, Jo Aaserud, Talha M. Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Patent number: 9139665
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: September 22, 2015
    Assignees: Life Technologies Corporation, Life Technologies AS
    Inventors: Geir Fonnum, Grete I. Modahl, Nini H. Kjus, Astrid E. Molteberg, Diem Tran, Jo Aaserud, Talha M. Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Publication number: 20140142254
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: November 18, 2013
    Publication date: May 22, 2014
    Applicants: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATION
    Inventors: Geir FONNUM, Grete I. MODAHL, Nini H. KJUS, Astrid E. MOLTEBERG, Diem TRAN, Jo AASERUD, Talha M. GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Publication number: 20140073738
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 13, 2014
    Applicants: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATION
    Inventors: Geir FONNUM, Grete I. MODAHL, Nini H. KJUS, Astrid E. MOLTEBERG, Diem TRAN, Jo AASERUD, Talha M. GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Publication number: 20140073715
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 13, 2014
    Applicants: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATION
    Inventors: Geir FONNUM, Grete I. MODAHL, Nini H. KJUS, Astrid E. MOLTEBERG, Diem TRAN, Jo AASERUD, Talha M. GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Patent number: 7560254
    Abstract: A method of characterizing a nucleic acid sample is provided that includes the steps of: (a) conducting a DNA polymerase reaction that includes the reaction of a template, an allele specific primer, at least one terminal phosphate-labeled nucleotide, DNA polymerase, and optionally an enzyme having 3??5? exonuclease activity when the primer is non-hydrolyzable, which reaction results in the production of labeled polyphosphate; (b) permitting the labeled polyphosphate to react with a phosphatase to produce a detectable species; (c) detecting the detectable species; and (d) characterizing the nucleic acid sample based on such detection.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: July 14, 2009
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Anup Sood, Shiv Kumar, Carl Fuller, John Nelson, John Macklin
  • Patent number: 7393640
    Abstract: The present invention describes methods of using terminal-phosphate-labeled nucleotides in the presence of a manganese salt to enhance their substrate properties towards various enzymes. Particularly described are methods of detecting a nucleic acid in a sample, based on the use of terminal-phosphate-labeled nucleotides as substrates for nucleic acid polymerases, in the presence of a manganese salt. Further provided are manganese complexes of terminal-phosphate-labeled nucleotides as well as terminal-phosphate-labeled nucleotides with new linkers with enhanced substrate properties.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: July 1, 2008
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Shiv Kumar, Mark McDougall, Anup Sood, John Nelson, Carl Fuller, John Macklin, Paul Mitsis
  • Publication number: 20070292879
    Abstract: The present invention describes terminal phosphate blocked nucleoside polyphosphates that are stable at high temperature and their use in nucleic acid amplification and analysis. Current invention further describes charge modified terminal phosphate blocked nucleoside polyphosphates for improved incorporation and direct loading of nucleic acid sequencing reactions onto separating media.
    Type: Application
    Filed: July 24, 2007
    Publication date: December 20, 2007
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: ANUP SOOD, SHIV KUMAR, CARL FULLER, JOHN NELSON
  • Patent number: 7256019
    Abstract: The present invention describes terminal phosphate blocked nucleoside polyphosphates that are stable at high temperature and their use in nucleic acid amplification and analysis. Current invention further describes charge modified terminal phosphate blocked nucleoside polyphosphates for improved incorporation and direct loading of nucleic acid sequencing reactions onto separating media.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: August 14, 2007
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Anup Sood, Shiv Kumar, Carl Fuller, John Nelson