Patents by Inventor Carl H. Behrens

Carl H. Behrens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
    Patent number: 5428040
    Abstract: This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, chronic inflammatory diseases, including but not limited to psoriasis and rheumatoid arthritis, and cancer in a mammal.
    Type: Grant
    Filed: August 31, 1993
    Date of Patent: June 27, 1995
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Ronald L. Magolda, William J. Pitts, Irina C. Jacobson, Carl H. Behrens, Michael J. Orwat, Douglas G. Batt
  • 3-phenyl-5,6-dihydrobenziciacridine-7-carboxylic acids and related compounds as immunosuppressive agents
    Patent number: 5190753
    Abstract: Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, psoriasis and chronic inflammatory diseases.
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: March 2, 1993
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Carl H. Behrens, Bruce D. Jaffee
  • 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
    Patent number: 5135934
    Abstract: Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, psoriasis and chronic inflammatory diseases.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: August 4, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Carl H. Behrens, Bruce D. Jafee
  • Benzothienobenzacridine-7-carboxylic acids as cancer chemotherapeutic agents
    Patent number: 5002954
    Abstract: Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful in treating tumors in mammals. These dihydrobenz[c]acridine carboxylic acid derivatives have the formula: ##STR1## or a pharmaceutically acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification. Also provided are pharmaceutical compositions of said compounds. In addition, processes for the preparation of these compounds are disclosed.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: March 26, 1991
    Inventor: Carl H. Behrens
  • 1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
    Patent number: 4942163
    Abstract: 3-(1-Naphthalenyl)-1(2H)-isoquinolinones and 3-(1-naphthalenyl)-1-isoquinolineamines are useful as cancer chemotherapeutic agents.
    Type: Grant
    Filed: March 7, 1989
    Date of Patent: July 17, 1990
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Carl H. Behrens
  • 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents
    Patent number: 4918077
    Abstract: Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful in treating tumors in mammals. These dihydrobenz[c]acridine carboxylic acid derivatives have the formula: ##STR1## or a pharmaceutically acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification. Also provided are pharmaceutical compositions of said compounds. In addition, processes for the preparation of these compounds are disclosed.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: April 17, 1990
    Assignee: E. I. Du Pont de Nemours & Co., Inc.
    Inventor: Carl H. Behrens