Abstract: The present invention is directed to use of the GLP-1 receptor agonist semaglutide in medical therapy for the treatment of non-alcoholic steatohepatitis.

Abstract: An acoustic attenuation enclosure providing a plurality of panels connectable to define a boundary of the acoustic attenuation enclosure housing an electroacoustic transducer converting an electrical audio signal propagated in an external environment, wherein the acoustic attenuation enclosure substantially maintains a first acoustics regardless of a second acoustics of the external environment.

Abstract: A biofilter irrigation system comprises a cylindrical vessel having a central axis, a media bed positioned within the vessel, a spray head system positioned above the media bed, the spray head system comprising a central hub positioned at the central axis of the vessel, at least one arm extending distally from the central hub toward a wall of the vessel and configured to rotate about the central axis, and a plurality of nozzles connected to the at least one arm. The biofilter irrigation system further comprises a fluid outlet positioned below the media bed.

Abstract: A biofilter irrigation system comprises a cylindrical vessel having a central axis, a media bed positioned within the vessel, a spray head system positioned above the media bed, the spray head system comprising a central hub positioned at the central axis of the vessel, at least one arm extending distally from the central hub toward a wall of the vessel and configured to rotate about the central axis, and a plurality of nozzles connected to the at least one arm. The biofilter irrigation system further comprises a fluid outlet positioned below the media bed.

Abstract: A refrigeration appliance includes a fresh food compartment, a freezer compartment, and an ice maker within the fresh food compartment for freezing water into ice pieces. In one example, a rotatable auger drives the ice pieces out of a removable ice bin via a driving force applied in a first direction. A latch is configured to apply a resisting force to the ice bin along a second direction. In another example, an air mover is disposed within the ice maker for delivering cooled air from an ice maker evaporator to a region adjacent to the ice bin. At least one air channel is formed into an inside surface of the ice maker chamber. In another example, a method of making ice in the refrigeration appliance is provided. The method includes the steps of operating the air mover and a defrost heating of the ice maker evaporator.

Abstract: A refrigeration appliance includes a fresh food compartment, a freezer compartment, and an ice maker within the fresh food compartment for freezing water into ice pieces. In one example, a rotatable auger drives the ice pieces out of a removable ice bin via a driving force applied in a first direction. A latch is configured to apply a resisting force to the ice bin along a second direction. In another example, an air mover is disposed within the ice maker for delivering cooled air from an ice maker evaporator to a region adjacent to the ice bin. At least one air channel is formed into an inside surface of the ice maker chamber. In another example, a method of making ice in the refrigeration appliance is provided. The method includes the steps of operating the air mover and a defrost heating of the ice maker evaporator.

Abstract: A biofilter irrigation system comprises a cylindrical vessel having a central axis, a media bed positioned within the vessel, a spray head system positioned above the media bed, the spray head system comprising a central hub positioned at the central axis of the vessel, at least one arm extending distally from the central hub toward a wall of the vessel and configured to rotate about the central axis, and a plurality of nozzles connected to the at least one arm. The biofilter irrigation system further comprises a fluid outlet positioned below the media bed.

Abstract: A refrigeration appliance includes a fresh food compartment, a freezer compartment, and an ice maker within the fresh food compartment for freezing water into ice pieces. In one example, a rotatable auger drives the ice pieces out of a removable ice bin via a driving force applied in a first direction. A latch is configured to apply a resisting force to the ice bin along a second direction. In another example, an air mover is disposed within the ice maker for delivering cooled air from an ice maker evaporator to a region adjacent to the ice bin. At least one air channel is formed into an inside surface of the ice maker chamber. In another example, a method of making ice in the refrigeration appliance is provided. The method includes the steps of operating the air mover and a defrost heating of the ice maker evaporator.

Abstract: A refrigeration appliance includes a fresh food compartment, a freezer compartment, and an ice maker within the fresh food compartment for freezing water into ice pieces. In one example, a rotatable auger drives the ice pieces out of a removable ice bin via a driving force applied in a first direction. A latch is configured to apply a resisting force to the ice bin along a second direction. In another example, an air mover is disposed within the ice maker for delivering cooled air from an ice maker evaporator to a region adjacent to the ice bin. At least one air channel is formed into an inside surface of the ice maker chamber. In another example, a method of making ice in the refrigeration appliance is provided. The method includes the steps of operating the air mover and a defrost heating of the ice maker evaporator.

Abstract: Provided is a dryer for minimizing moisture entrained within a refrigerant used to provide a cooling effect to a temperature-controlled environment, and a refrigeration appliance including such a dryer. The dryer includes a housing defining a drying chamber and a desiccant disposed within the drying chamber for removing at least a portion of the moisture from the refrigerant. A first outlet is formed in the housing adjacent a lower region of the drying chamber when the drying chamber is viewed in an operational orientation. A second outlet is also formed in the housing at an elevation vertically above the first outlet when the dryer is viewed in the operational orientation for discharging at least a portion of the refrigerant introduced into the drying chamber to be delivered to a second heat exchanger with a relatively-low internal pressure. The elevation of the second outlet relative to the first outlet promotes the discharge of the refrigerant through the first outlet instead of through the second outlet.

Abstract: Provided is an ice maker that includes a mold including a plurality of cavities for receiving water to be frozen into ice pieces, a driver operatively connected to the mold for adjusting a position of the mold to a plurality of different locations during an ice making cycle, and a controller. A limit switch is located at a plurality of different positions along a range of travel of the mold to be actuated and transmit a signal indicative of the mold's arrival at the different locations. The mold can travel along path including first portion having a first axis of rotation and a substantially vertical portion, and can be driven by a motor with a drive shaft rotatable about a single axis of rotation. The motor can drive both the mold and a bail arm, and the mold can be leveled upon reaching a predetermined location. The ice maker can perform a Dry Cycle in response to detecting an anomaly during ice making.

Abstract: Provided is a method and system for forming ice pieces with an ice maker that includes a mold defining a plurality of cavities for receiving water to be frozen into ice pieces. A processor controls delivery of a refrigerant to freeze water received in the plurality of cavities into ice pieces. A freeze signal transmitted by a temperature sensor embedded within the mold is received by the processor, the freeze signal indicating that a temperature of a portion of the mold adjacent to the temperature sensor has reached a freeze temperature where the water in at least one of the cavities has achieved a frozen state to initiate harvesting of the frozen ice pieces. Defrosting a system evaporator can also be coordinated with operation of the ice maker.

Abstract: Microfluidic systems are disclosed, including microfluidic devices and methods, useful for simultaneously analyzing multiple analytes in each of a plurality of distinct nanoliter-volume samples.

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

Abstract: An ion trap comprising elongate rods, electrodes, a first circuit, and a second circuit. The rods are for defining the radial extent of a trapping volume. The first circuit is connected to the rods for applying thereto a first RF signal that generates adjacent the trapping volume a radial RF containment field that radially contains ions of different polarities within the trapping volume. The electrodes define the axial extent of the trapping volume. The second circuit is connected to the electrodes for applying thereto a second RF signal that generates adjacent the trapping volume an axial RF containment field that axially contains the ions of different polarities within the trapping volume. The axial RF containment field is independent of the radial RF containment field.

Abstract: Provided is a dryer for minimizing moisture entrained within a refrigerant used to provide a cooling effect to a temperature-controlled environment, and a refrigeration appliance including such a dryer. The dryer includes a housing defining a drying chamber and a desiccant disposed within the drying chamber for removing at least a portion of the moisture from the refrigerant. A first outlet is formed in the housing adjacent a lower region of the drying chamber when the drying chamber is viewed in an operational orientation. A second outlet is also formed in the housing at an elevation vertically above the first outlet when the dryer is viewed in the operational orientation for discharging at least a portion of the refrigerant introduced into the drying chamber to be delivered to a second heat exchanger with a relatively-low internal pressure. The elevation of the second outlet relative to the first outlet promotes the discharge of the refrigerant through the first outlet instead of through the second outlet.

Abstract: Provided is a method and system for forming ice pieces with an ice maker that includes a mold defining a plurality of cavities for receiving water to be frozen into ice pieces. A processor controls delivery of a refrigerant to freeze water received in the plurality of cavities into ice pieces. A freeze signal transmitted by a temperature sensor embedded within the mold is received by the processor, the freeze signal indicating that a temperature of a portion of the mold adjacent to the temperature sensor has reached a freeze temperature where the water in at least one of the cavities has achieved a frozen state to initiate harvesting of the frozen ice pieces. Defrosting a system evaporator can also be coordinated with operation of the ice maker.

Abstract: Provided is an ice maker that includes a mold including a plurality of cavities for receiving water to be frozen into ice pieces, a driver operatively connected to the mold for adjusting a position of the mold to a plurality of different locations during an ice making cycle, and a controller. A limit switch is located at a plurality of different positions along a range of travel of the mold to be actuated and transmit a signal indicative of the mold's arrival at the different locations. The mold can travel along path including first portion having a first axis of rotation and a substantially vertical portion, and can be driven by a motor with a drive shaft rotatable about a single axis of rotation. The motor can drive both the mold and a bail arm, and the mold can be leveled upon reaching a predetermined location. The ice maker can perform a Dry Cycle in response to detecting an anomaly during ice making.

Abstract: An ion trap comprising elongate rods, electrodes, a first circuit, and a second circuit. The rods are for defining the radial extent of a trapping volume. The first circuit is connected to the rods for applying thereto a first RF signal that generates adjacent the trapping volume a radial RF containment field that radially contains ions of different polarities within the trapping volume. The electrodes define the axial extent of the trapping volume. The second circuit is connected to the electrodes for applying thereto a second RF signal that generates adjacent the trapping volume an axial RF containment field that axially contains the ions of different polarities within the trapping volume. The axial RF containment field is independent of the radial RF containment field.

Abstract: High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.