Patents by Inventor Carl J. Malizio

Carl J. Malizio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of targeting pharmaceuticals to motor neurons
    Patent number: 6670322
    Abstract: A method of targeting therapeutic molecules to motor neurons is disclosed. In one embodiment, this method comprises the steps of (a) synthesizing a prodrug comprising a therapeutic molecule covalently bound to a polymeric delivery vehicle, and (b) conjugating the prodrug to a botulinum neurotoxin heavy chain.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: December 30, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael C. Goodnough, Eric A. Johnson, William H. Tepp, Carl J. Malizio
  • Method of targeting pharmaceuticals to motor neurons
    Publication number: 20030147921
    Abstract: A method of targeting therapeutic molecules to motor neurons is disclosed. In one embodiment, this method comprises the steps of (a) synthesizing a prodrug comprising a therapeutic molecule covalently bound to a polymeric delivery vehicle, and (b) conjugating the prodrug to a botulinum neurotoxin heavy chain.
    Type: Application
    Filed: May 30, 2001
    Publication date: August 7, 2003
    Inventors: Michael C. Goodnough, Eric A. Johnson, William H. Tepp, Carl J. Malizio
  • Chimeric toxins
    Patent number: 6545126
    Abstract: A chimeric toxin is disclosed. In a preferred embodiment, the chimeric toxin comprises a botulinal neurotoxin heavy chain and non-clostridial toxin chain. A method of creating a chimeric toxin is also disclosed. The chimeric toxin will have utility for pharmacological treatment of neurological disorders.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: April 8, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric A. Johnson, Michael C. Goodnough, Carl J. Malizio, Alan B. Scott
  • Purification of type G botulinum neurotoxin and pharmaceutical compositions thereof
    Patent number: 5846929
    Abstract: The isolation and purification of type G botulinum neurotoxin and complexes thereof is disclosed. Compositions containing the type G neurotoxin and the preparation of a type G toxoid are also disclosed.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: December 8, 1998
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric A. Johnson, Hiroshi Sugiyama, Carl J. Malizio