Patents by Inventor Carl J. Wheeler

Carl J. Wheeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADJUVANT COMPOSITIONS AND METHODS FOR ENHANCING IMMUNE RESPONSES TO POLYNUCLEOTIDE-BASED VACCINES
    Publication number: 20140065189
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 6, 2014
    Inventor: CARL J. WHEELER
  • ADJUVANT COMPOSITIONS AND METHODS FOR ENHANCING IMMUNE RESPONSES TO POLYNUCLEOTIDE-BASED VACCINES
    Publication number: 20130295139
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Application
    Filed: March 13, 2013
    Publication date: November 7, 2013
    Inventor: Carl J. WHEELER
  • Complex cationic lipids having quaternary nitrogens therein
    Patent number: 8541628
    Abstract: Cationic lipids having a derivatized quaternary ammonium head group that provide improved cell targeting ability and enhanced transfective efficacy for introducing molecules into cells are provided.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: September 24, 2013
    Assignee: Vical Incorporated
    Inventor: Carl J Wheeler
  • Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
    Patent number: 8415317
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: April 9, 2013
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • ADJUVANT COMPOSITIONS AND METHODS FOR ENHANCING IMMUNE RESPONSES TO POLYNUCLEOTIDE-BASED VACCINES
    Publication number: 20110165197
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Application
    Filed: February 18, 2011
    Publication date: July 7, 2011
    Applicant: Vical Incorporated
    Inventor: Carl J. WHEELER
  • Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
    Patent number: 7582613
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: September 1, 2009
    Assignee: Vical Incorporated
    Inventor: Carl J Wheeler
  • Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
    Publication number: 20080213306
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Application
    Filed: August 17, 2007
    Publication date: September 4, 2008
    Applicant: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
    Publication number: 20080145387
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Application
    Filed: August 17, 2007
    Publication date: June 19, 2008
    Applicant: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
    Patent number: 7105574
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: September 12, 2006
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Complex cationic lipids having quaternary nitrogens therein
    Publication number: 20040171572
    Abstract: Cationic lipids having a derivatized quaternary ammonium head group that provide improved cell targeting ability and enhanced transfective efficacy for introducing molecules into cells are provided.
    Type: Application
    Filed: December 30, 2003
    Publication date: September 2, 2004
    Inventor: Carl J. Wheeler
  • Complex cationic lipids having quarternary nitrogens therein
    Patent number: 6670332
    Abstract: Cationic lipids having a derivatized quaternary ammonium head group that provide improved cell targeting ability and enhanced transfective efficacy for introducing molecules into cells are provided.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: December 30, 2003
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
    Publication number: 20030191082
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Application
    Filed: March 19, 2003
    Publication date: October 9, 2003
    Inventor: Carl J. Wheeler
  • Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
    Patent number: 6586409
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: July 1, 2003
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Piperazine based cytofectins
    Patent number: 6022874
    Abstract: The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: February 8, 2000
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Quaternary cytofectins
    Patent number: 5994317
    Abstract: Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having functional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.
    Type: Grant
    Filed: April 9, 1996
    Date of Patent: November 30, 1999
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Piperazine based cytofectins
    Patent number: 5861397
    Abstract: The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: January 19, 1999
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler