Abstract: N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .beta.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.

Abstract: Bis-phenoxypropanolamine derivatives are prepared. These compounds have .beta.-adrenergic stimulant activity particularly as selective bronchodilators.

Abstract: .alpha.-Aminoalkyl-3-(1,2-dihydroxyethyl)-4-hydroxy-benzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are disclosed.

Abstract: Pharmaceutical compositions and a method of stimulating peripheral dopamine receptors by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal. Renal vasodilator and diuretic methods are also disclosed.

Abstract: Phenoxypropanolamine derivatives are prepared. These compounds have .beta.-adrenergic stimulant activity particularly as selective bronchodilators.

Abstract: A series of 3-alkylamino-.alpha.-substituted aminomethyl-4-hydroxybenzyl alcohols are prepared. These compounds are .beta.-adrenergic stimulants, in particular as bronchodilators.

Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.

Abstract: 3-Substituted-3-hydroxyphenyl-2-piperidylcarbinols are prepared. These compounds are .beta.-adrenergic stimulants and are useful in particular as bronchodilators.

Abstract: .alpha.-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selected bronchodilators, are prepared from 4-hydroxyphenones by conversion to a 3-alkylsulfonylmethylphenone, bromination of these phenones and treatment of the resulting .alpha.-bromo derivatives with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove the benzyl groups and reduce the ketone moiety.

Abstract: Halogen substituted .alpha.-(aminoalkyl)-3,4-dihydroxybenzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators. The .alpha.-aminomethyl derivatives are prepared by the condensation of an appropriately substituted styrene oxide with a primary amine followed by removal of the ether protective group(s). The .alpha.-aminoethyl or .alpha.-aminopropyl derivatives are prepared by the condensation of an appropriately substituted .alpha.-bromoalkyl phenyl ketone with an N-benzyl secondary amine followed by reduction of the ketone moiety and removal of the ether protective group(s).

Abstract: 4-Hydroxy-.alpha.-[(3,4-methylenedioxyphenyl)isopropylaminomethyl]-3-(methy lsulfonylmethyl)benzyl alcohol having .beta.-adrenergic stimulant activity, particularly as a selective bronchodilator, is prepared from 4-hydroxyacetophenone by conversion to 3-methylsulfonylmethylacetophenone, bromination and conversion of this phenone to the phenylglyoxal and treatment of the resulting glyoxal derivative with 3,4-methylenedioxyphenylisopropylamine followed by simultaneous reduction of the imine and ketone moieties and catalytic hydrogenation to remove the benzyl group.

Abstract: .alpha.-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selected bronchodilators, are prepared from 4-hydroxyphenones by conversion to a 3-alkylsulfonylmethylphenone, bromination of these phenones and treatment of the resulting .alpha.-bromo derivatives with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove the benzyl groups and reduce the ketone moiety.

Abstract: .alpha.-Aminomethyl-5-hydroxy-2-pyridinemethanols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are prepared generally from a 2-pyridine-carboxaldehyde by reaction with an appropriate isocyanide, via an amide intermediate followed by reduction to an amine and finally catalytic hydrogenation to remove benzyl protective groups.

Abstract: A series of 3-alkylamino-.alpha.-substituted aminomethyl-4-hydroxybenzyl alcohols are prepared. These compounds are .beta.-adrenergic stimulants, in particular as bronchodilators.

Abstract: .alpha.-Aminomethyl-4-hydroxy-3-sulfamylbenzyl alcohols and 4-hydroxy-3-sulfamylphenethylamines are disclosed. These compounds have .beta.-adrenergic antagonist activity.

Abstract: 1,2,3,4-Tetrahydroisoquinoline compounds having 7 and 8 halo substituents are inhibitors of phenylethanolamine N-methyltransferase.

Abstract: N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or-2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .alpha.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.