Abstract: The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.

Abstract: A wheelchair system and an accessory system for a wheelchair are disclosed. According to one embodiment, the accessory system may include an accessory frame having one or more interface elements to mount to a wheelchair frame. The accessory system may include a wheel assembly rotatably coupled to the accessory frame by a first fastener. The accessory system may include an engagement system further coupling the accessory frame to the wheel assembly. The engagement system may include a channel guide member defining a channel having a notched region. The channel guide member may be rotatably coupled to one of the accessory frame or wheel assembly by a second fastener. The engagement system may further include a translating member retained within the channel of the channel guide member. The translating member may be fixed to another one of the accessory frame or wheel assembly.

Abstract: A wheelchair system and an accessory system for a wheelchair are disclosed. According to one embodiment, the accessory system may include an accessory frame having one or more interface elements to mount to a wheelchair frame. The accessory system may include a wheel assembly rotatably coupled to the accessory frame by a first fastener. The accessory system may include an engagement system further coupling the accessory frame to the wheel assembly. The engagement system may include a channel guide member defining a channel having a notched region. The channel guide member may be rotatably coupled to one of the accessory frame or wheel assembly by a second fastener. The engagement system may further include a translating member retained within the channel of the channel guide member. The translating member may be fixed to another one of the accessory frame or wheel assembly.

Abstract: A wheelchair system and an accessory system for a wheelchair are disclosed. According to one embodiment, the accessory system may include an accessory frame having one or more interface elements to mount to a wheelchair frame. The accessory system may include a wheel assembly rotatably coupled to the accessory frame by a first fastener. The accessory system may include an engagement system further coupling the accessory frame to the wheel assembly. The engagement system may include a channel guide member defining a channel having a notched region. The channel guide member may be rotatably coupled to one of the accessory frame or wheel assembly by a second fastener. The engagement system may further include a translating member retained within the channel of the channel guide member. The translating member may be fixed to another one of the accessory frame or wheel assembly.

Abstract: A wheelchair system and an accessory system for a wheelchair are disclosed. According to one embodiment, the accessory system may include an accessory frame having one or more interface elements to mount to a wheelchair frame. The accessory system may include a wheel assembly rotatably coupled to the accessory frame by a first fastener. The accessory system may include an engagement system further coupling the accessory frame to the wheel assembly. The engagement system may include a channel guide member defining a channel having a notched region. The channel guide member may be rotatably coupled to one of the accessory frame or wheel assembly by a second fastener. The engagement system may further include a translating member retained within the channel of the channel guide member. The translating member may be fixed to another one of the accessory frame or wheel assembly.

Abstract: The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.

Abstract: The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.

Abstract: The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.

Abstract: The present invention is a padded garment covering the lower torso and upper legs of paraplegics, who have lost not only control of their legs but any sensation of pain, said garments providing protection against bruises and abrasions caused by sliding about on floors, collisions with edges and corners, and/or other activities involved in moving about, the padding of said garment having a resilient core resistent to complete collapse and covered with a surface resistent to puncture or wear by the described activities and devoid of seams, fasteners, and other protrusions which could cause injury by chafing, said garment capable of conforming to any of several body positions.

Abstract: The invention generally relates to cell-specific expression vectors. It particularly relates to targeted gene therapy using recombinant expression vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional expression vectors and methods for using them. Such vectors are able to selectively replicate in a target cell or tissue to provide a therapeutic benefit in a tissue from the presence of the vector per se or from one or more heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated.

Abstract: The invention generally relates to cell-specific expression vectors. It particularly relates to targeted gene therapy using recombinant expression vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional expression vectors and methods for using them. Such vectors are able to selectively replicate in a target cell or tissue to provide a therapeutic benefit in a tissue from the presence of the vector per se or from one or more heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated.

Abstract: The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order: A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.

Abstract: A pedalling attachment for wheelchairs, to form a composite vehicle therewith, which includes an attachment frame with a pedalling mechanism and novel attachment means thereon. The attachment frame has two slidably and rotatably adjustable frames slidably insertable therein, with attachment means located at the ends thereof which grip appropriate portions of the wheelchair side frames. The attachment means are adjustable with respect to each other, to the attachment frame and to the wheelchair frames, so that a wide variety of sizes, configurations and styles of wheelchairs can be accomodated. The pedalling attachment, when attached to the wheelchair, makes the composite vehicle rigid enough to use safely on streets and highways, and to travel at highway speeds thereon for long distances.