Patents by Inventor CARL OSCAR BROWN

CARL OSCAR BROWN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITION OF INTRA-ARTICULAR CORTICOSTEROID FOR PAIN CONTROL
    Publication number: 20230285293
    Abstract: Provided is a method for treating joint pain in a subject with arthritis. The method comprises administering to the subject with a determined grade of osteoarthritis an effective amount of intra-articular corticosteroid or pharmaceutically acceptable salt thereof in a pharmaceutical composition. Achieved is robustness of the efficacy response to a treatment with intra-articular corticosteroid in predetermined subgroups of the intent-to-treat population.
    Type: Application
    Filed: August 5, 2021
    Publication date: September 14, 2023
    Inventors: Sheue-Fang SHIH, Carl Oscar BROWN
  • PHARMACEUTICAL COMPOSITIONS FOR USE IN TREATING PAIN
    Publication number: 20220071934
    Abstract: Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a molar ratio of the amide-type anesthetic to the at least one lipid of the lipid-based complex is at least 0.5:1. The total amount of the amide-type anesthetic is at least 1.5 to 5 times of a standard therapeutic dose for treating postsurgical pain with the amide-type anesthetic to achieve an improved pain control with desired prolonged analgesic effect.
    Type: Application
    Filed: February 26, 2020
    Publication date: March 10, 2022
    Inventors: TIEN-TZU TAI, YUN-LONG TSENG, SHEUE-FANG SHIH, MIN-WEN KUO, CARL OSCAR BROWN, HUI-TING WANG, WEENEE YEUN NG JAO, PEI-HSIEN HU, WAN-NI YU, KEELUNG HONG, HAO-WEN KAO, YI-YU LIN
  • Methods and pharmaceutical compositions for preventing or treating immunoinflammatory dermal disorders
    Patent number: 10675260
    Abstract: A method for preventing or treating immunoinflammatory dermal disorders is provided. Also provided is a pharmaceutical composition for preventing or treating immunoinflammatory dermal disorders.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 9, 2020
    Assignee: TWi Biotechnology, Inc.
    Inventors: Po-Yuan Tseng, Wei-Shu Lu, Carl Oscar Brown, III, I-Yin Lin, III, Chen-En Tsai, Chih-Kuang Chen
  • Diacerein or rhein topical formulations and uses thereof
    Patent number: 10512625
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: December 24, 2019
    Assignee: TWI BIOTECHNOLOGY, INC.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF
    Publication number: 20190105296
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Methods for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex using diacerein or its analogs
    Patent number: 10195170
    Abstract: Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: February 5, 2019
    Assignee: TWI Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Diacerein or Rhein topical formulations and uses thereof
    Patent number: 10154984
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: December 18, 2018
    Assignee: TWi Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING IMMUNOINFLAMMATORY DERMAL DISORDERS
    Publication number: 20180200235
    Abstract: A method for preventing or treating immunoinflammatory dermal disorders is provided.
    Type: Application
    Filed: January 19, 2018
    Publication date: July 19, 2018
    Inventors: Po-Yuan Tseng, Wei-Shu Lu, Carl Oscar Brown, III, I-Yin Lin, III, Chen-En Tsai, Chih-Kuang Chen
  • DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF
    Publication number: 20180021290
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: July 25, 2017
    Publication date: January 25, 2018
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • METHODS AND FORMULATIONS FOR TREATMENT AND/OR PREVENTION OF BLOOD-ASSOCIATED DISORDERS
    Publication number: 20170319532
    Abstract: A method of treating and/or preventing blood-associated disorders is provided. Also provided is a method of treating and/or preventing hemophilic arthropathy and/or hemochromatosis arthropathy in a subject.
    Type: Application
    Filed: May 5, 2017
    Publication date: November 9, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Diacerein or rhein topical formulations and uses thereof
    Patent number: 9744131
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 29, 2017
    Assignee: TWi Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • METHODS FOR INHIBITING EXPRESSION OF ASC, EXPRESSION OF NLRP3, AND/OR FORMATION OF NLRP3 INFLAMMASOME COMPLEX USING DIACEREIN OR ITS ANALOGS
    Publication number: 20170049733
    Abstract: Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.
    Type: Application
    Filed: August 17, 2016
    Publication date: February 23, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF
    Publication number: 20170000732
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 5, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • FORMULATIONS CONTAINING DIACEREIN AND METHODS OF LOWERING BLOOD LEVELS OF URIC ACID USING THE SAME
    Publication number: 20160303050
    Abstract: A controlled-release formulation containing diacerein or its analogs is provided. Also provided is a method of lowering blood levels of uric acid using this formulation.
    Type: Application
    Filed: April 20, 2015
    Publication date: October 20, 2016
    Inventors: Hanpin Lim, Carl Oscar Brown, III, Wei-Shu Lu, Tien-Kuen Chung, Chih-Kuang Chen