Abstract: Disclosed is a method for determining a possible bacterial infection in a patient exhibiting symptoms selected from specific internal symptoms of disease, and/or diffuse and general manifestations of disease, and/or is a blood donor. The method includes: i) determining a) the level of a Rickettsia analyte in a sample 1 from a patient exhibiting symptoms, possibly combined with b) the level of a Borrelia analyte in a sample 2 from the same patient; ii) considering that the symptoms exhibited by the patient involve a) rickettsiosis if the level of the Rickettsia analyte in sample 1 is elevated, and b) borrelios if the level of the Borrelia analyte in sample 2 is elevated. For blood donors step, (ii) means that whole blood and blood fractions are considered to be infected with Rickettsia and/or Borrelia, respectively, when these levels are elevated. Also disclosed is a corresponding kit.

Abstract: The present invention relates to the positioning of nanoparticles on surfaces, and in particular to a method for first positioning nucleic acid polymers onto surface defects on a surface in order to utilise the principle of base pairing for achieving a site specific organisation of particles and macromolecules. The inventive method comprises the positioning of corresponding base pairs in the form of primers on the particles or macromolecules to be positioned, and a high resolution, preferably a resolution of 1-50 nm can be achieved.