Patents by Inventor Carl Reppucci
Carl Reppucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160199296Abstract: The present invention provides pharmaceutical compositions for intranasal delivery of a benzodiazepine. The composition may contain a therapeutically effective amount of a benzodiazepine or a pharmaceutically acceptable salt thereof, and a permeation enhancer. The permeation enhancer may be propylene glycol or a Hsieh permeation enhancer. The present compositions have excellent bioavailability. After administration of the present compositions, therapeutically effective plasma levels of the benzodiazepine may be achieved rapidly. The present pharmaceutical composition may be used to treat a patient suffering from anxiety, epilepsy, insomnia, agitation, seizures, muscular disorders, alcohol dependence, and drug withdrawal.Type: ApplicationFiled: March 24, 2016Publication date: July 14, 2016Inventors: Nils Bergenhem, Carl Reppucci, Zhengmao Li
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Patent number: 9358206Abstract: Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier.Type: GrantFiled: September 11, 2013Date of Patent: June 7, 2016Assignee: CPEX Pharmaceutical, Inc.Inventors: Robert J. Gyurik, Carl Reppucci
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Publication number: 20140128379Abstract: The present invention provides pharmaceutical compositions for intranasal delivery of a benzodiazepine. The composition may contain a therapeutically effective amount of a benzodiazepine or a pharmaceutically acceptable salt thereof, and a permeation enhancer. The permeation enhancer may be propylene glycol or a Hsieh permeation enhancer. The present compositions have excellent bioavailability. After administration of the present compositions, therapeutically effective plasma levels of the benzodiazepine may be achieved rapidly. The present pharmaceutical composition may be used to treat a patient suffering from anxiety, epilepsy, insomnia, agitation, seizures, muscular disorders, alcohol dependence, and drug withdrawal.Type: ApplicationFiled: March 29, 2012Publication date: May 8, 2014Applicant: CPEX Pharmaceuticals, Inc.Inventors: Nils Bergenhem, Carl Reppucci, Zhengmao Li
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Publication number: 20140073570Abstract: Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier.Type: ApplicationFiled: September 11, 2013Publication date: March 13, 2014Inventors: Robert J. GYURIK, Carl REPPUCCI
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Patent number: 8541359Abstract: Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier.Type: GrantFiled: September 18, 2009Date of Patent: September 24, 2013Assignee: CPEX Pharmaceuticals, Inc.Inventors: Robert J. Gyurik, Carl Reppucci
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Patent number: 8044020Abstract: Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.Type: GrantFiled: November 6, 2009Date of Patent: October 25, 2011Inventors: Robert J. Gyurik, Carl Reppucci
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Patent number: 7989419Abstract: Pharmaceutical compositions for nasal administration to humans, or to warm-blooded animals, comprise: (A) a therapeutically effective amount of insulin; (B) a permeation enhancer; and (C) a liquid carrier; the compositions being further comprised of, or characterized by, any, or each, of: (D) a combination of non-ionic surfactants; wherein the combination of non-ionic surfactants comprises: (i) at least one fatty acid ester of a sugar or sugar alcohol and (ii) at least one pegylated fatty acid ester of a sugar or sugar alcohol; (E) an acidic pH, but no greater than a pH of 4.5; and (F) an osmolality of <200 mOsmol/Kg H2O.Type: GrantFiled: June 8, 2007Date of Patent: August 2, 2011Assignee: CPEX Pharmaceuticals, Inc.Inventors: Robert J. Gyurik, Carl Reppucci
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Publication number: 20110097363Abstract: The present invention provides a preparation of a therapeutically effective amount of insulin with a concentration of A21 desamido insulin greater than about 2% (w/w).Type: ApplicationFiled: October 12, 2010Publication date: April 28, 2011Applicant: CPEX PHARMACEUTICALS, INC.Inventors: Fred Feldman, Zhengmao Li, Jeffrey Banas, Carl Reppucci
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Patent number: 7816318Abstract: Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of the pharmaceutically active agent; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier; and wherein the Hsieh enhancer has the following structure: wherein X and Y are oxygen, sulfur or an imino group of the structure or ?N—R with the proviso that when Y is the imino group, X is an imino group, and when Y is sulfur, X is sulfur or an imino group; A is a group having the structure and the remaining variables are defined herein.Type: GrantFiled: June 7, 2007Date of Patent: October 19, 2010Assignee: CPEX Pharmaceuticals, Inc.Inventors: Robert J. Gyurik, Carl Reppucci
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Publication number: 20100144593Abstract: Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.Type: ApplicationFiled: November 6, 2009Publication date: June 10, 2010Applicant: CPEX PHARMACEUTICALS, INC.Inventors: Robert J. Gyurik, Carl Reppucci
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Patent number: 7651996Abstract: Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.Type: GrantFiled: August 24, 2006Date of Patent: January 26, 2010Assignee: CPEX Pharmaceuticals, Inc.Inventors: Robert J. Gyurik, Carl Reppucci
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Publication number: 20100009921Abstract: Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier; and wherein the Hsieh enhancer has the following structure: wherein X and Y are oxygen, sulfur or an imino group of the structure or ?N—R with the proviso that when Y is the imino group, X is an imino group, and when Y is sulfur, X is sulfur or an imino group, A is a group having the structure wherein X and Y are defined above, m and n are integers having a value from 1 to 20 aType: ApplicationFiled: September 18, 2009Publication date: January 14, 2010Applicant: CPEX PHARMACEUTICALS, INC.Inventors: Robert J. Gyurik, Carl Reppucci
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Publication number: 20090156464Abstract: Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.Type: ApplicationFiled: December 18, 2008Publication date: June 18, 2009Applicant: CPEX PHARMACEUTICALS, INC.Inventors: Robert J. Gyurik, Carl Reppucci
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Publication number: 20080107735Abstract: Topically applied pharmaceutical products comprising (a) an active ingredient, (b) an organogel, and (c) a non-irritating permeation enhancer, are disclosed, along with and methods of use and formulations thereof. The topically applied products and methods are intended to be used to enhance any of the transdermal, subdermal, transmembrane, musculoskeletal, transungual, transonychial, and/or peronychial deliveries of a therapeutically effective amount of an active ingredient to a patient. The invention is particularly directed to topically applied pharmaceutical products for enhancing the delivery of a therapeutically effective amount of an active ingredient to a diseased or infected nail bed, nail matrix, and/or nail plate in the toenails or fingernails of a patient suffering from onychomycosis. The invention is also directed to delivery of an anti-inflammatory agent, preferably of the Cox-2 enzyme inhibitory class, topically to a site of soft tissue injury or discomfort.Type: ApplicationFiled: November 2, 2006Publication date: May 8, 2008Inventors: Robert J. Gyurik, Carl Reppucci
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Publication number: 20080045446Abstract: Pharmaceutical compositions for nasal administration to humans, or to warm-blooded animals, comprise: (A) a therapeutically effective amount of insulin; (B) a permeation enhancer; and (C) a liquid carrier; the compositions being further comprised of, or characterized by, any, or each, of: (D) a combination of non-ionic surfactants; wherein the combination of non-ionic surfactants comprises: (i) at least one fatty acid ester of a sugar or sugar alcohol and (ii) at least one pegylated fatty acid ester of a sugar or sugar alcohol; (E) an acidic pH, but no greater than a pH of 4.5; and (F) an osmolality of <200 mOsmol/Kg H2O.Type: ApplicationFiled: June 8, 2007Publication date: February 21, 2008Inventors: Robert Gyurik, Carl Reppucci
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Publication number: 20080045447Abstract: Compositions and methods are disclosed for treating a patient with insulin, wherein a composition in a form suitable for nasal delivery to a patient comprises a therapeutically effective amount of insulin, a permeation enhancer, a liquid carrier, and an acid present in said composition in an amount sufficient to provide an acidic pH, but not greater than a pH of 4.5, said acid being selected from the group consisting of: monovalent inorganic acid(s), sulfuric acid, and acetic acid. Preferably the composition is essentially-free of citrate(s) and essentially-free of phosphate(s). The composition being thus designed with the intent to provide a composition that is essentially-free of fibrilliform (or beta-sheet) insulin polymorphs.Type: ApplicationFiled: June 8, 2007Publication date: February 21, 2008Inventors: Robert Gyurik, Carl Reppucci, Zhengmao Li
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Publication number: 20070265191Abstract: Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier; and wherein the Hsieh enhancer has the following structure: wherein X and Y are oxygen, sulfur or an imino group of the structure or ?N—R with the proviso that when Y is the imino group, X is an imino group, and when Y is sulfur, X is sulfur or an imino group, A is a group having the structure wherein X and Y are defined above, m and n are integers having a value from 1 to 20Type: ApplicationFiled: June 7, 2007Publication date: November 15, 2007Inventors: Robert Gyurik, Carl Reppucci
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Patent number: 7244703Abstract: Compositions and methods for treating a patient with a pharmaceutically active peptide that combines a pharmaceutically active peptide, a permeation enhancer, and a carrier, are disclosed.Type: GrantFiled: March 5, 2004Date of Patent: July 17, 2007Assignee: Bentley Pharmaceuticals, Inc.Inventors: Robert J. Gyurik, Carl Reppucci
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Publication number: 20070010425Abstract: Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.Type: ApplicationFiled: August 24, 2006Publication date: January 11, 2007Inventors: Robert Gyurik, Carl Reppucci
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Patent number: 7112561Abstract: Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.Type: GrantFiled: December 2, 2004Date of Patent: September 26, 2006Assignee: Bentley Pharmaceuticals, Inc.Inventors: Robert J. Gyurik, Carl Reppucci