Abstract: A method for the prevention of alcohol-induced thirst and/or fatigue and/or nausea, as well as other less common after-effects resulting from an excessive ingestion of alcohol. The method comprises administering an effective amount of a pharmaceutically acceptable, non-toxic member of the class of antagonists of 5-hydroxytryptamine (hereinafter referred to as 5-HT). For maximum effectiveness, the antagonist of 5-HT is administered prior to or during the onset of the acute post-alcoholic intoxication state. The indication for therapy is subjective, and the therapy is utilized pro re nata.

Abstract: A composition and method for the prevention of alcohol-induced thirst and/or fatigue and/or nausea, as well as other less common after-effects resulting from excess alcohol ingestion wherein the composition is formulated to contain a dibenzocycloheptatriene derivative such as cyproheptadine and a lysergic acid derivative such as ergotamine. It has been found that these two classes of antagonists of 5-hydroxytryptamine act synergistically in minimizing or preventing an acute inflammatory reaction otherwise resulting from ingestion of excess alcohol.