Patents by Inventor Carl Saxinger

Carl Saxinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
    Patent number: 7304127
    Abstract: The present invention provides, among other things, a polypeptide that binds with the gp120 envelope protein of HIV, in particular HIV-1, under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a composition comprising such a polypeptide or nucleic acid or an antibody and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of making an antibody to gp120, and a method of removing HIV from a bodily fluid.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: December 4, 2007
    Assignee: United States of America as represented by the Secretary, Department of Health and Human Services
    Inventor: Carl Saxinger
  • Polypeptides comprising IL-6 ligand binding receptor domains
    Patent number: 7144986
    Abstract: The present invention provides, among other things, a polypeptide, and a pharmaceutically acceptable salt thereof, that inhibits the binding of IL-6 ligand with IL-6 receptor under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a nucleic acid that comprises or encodes an antisense nucleic acid molecule or a ribozyme that is specific for such a polypeptide, an antibody that is specific to such a polypeptide, an anti-antibody thereto, a composition comprising such a polypeptide, nucleic acid, antibody or an anti-body and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of prophylactically or therapeutically inhibiting IL-6 signaling in a mammal in need thereof, a mammal in need thereof, and a method of removing IL-6 ligand from a bodily fluid of an animal.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: December 5, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Carl Saxinger
  • Polypeptides comprising IL-6 ligand binding receptor domains
    Publication number: 20040092720
    Abstract: The present invention provides, among other things, a polypeptide, and a pharmaceutically acceptable salt thereof, that inhibits the binding of IL-6 ligand with IL-6 receptor under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a nucleic acid that comprises or encodes an antisense nucleic acid molecule or a ribozyme that is specific for such a polypeptide, an antibody that is specific to such a polypeptide, an anti-antibody thereto, a composition comprising such a polypeptide, nucleic acid, antibody or an anti-body and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of prophylactically or therapeutically inhibiting IL-6 signaling in a mammal in need thereof, a mammal in need thereof, and a method of removing IL-6 ligand from a bodily fluid of an animal.
    Type: Application
    Filed: November 5, 2003
    Publication date: May 13, 2004
    Applicant: The Govemment of the U.S. A.,as Represented by the Secretary, Dept. of Health and Human Services
    Inventor: Carl Saxinger
  • Polypeptides comprising IL-6 ligand-binding receptor domains
    Patent number: 6664374
    Abstract: The present invention provides, among other things, a polypeptide, and a pharmaceutically acceptable salt. thereof, that inhibits the binding of IL-6 ligand with IL-6 receptor under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a nucleic acid that comprises or encodes an antisense nucleic acid molecule or a ribozyme that is specific for such a polypeptide, an antibody that is specific to such a polypeptide, an anti-antibody thereto, a composition comprising such a polypeptide, nucleic acid, antibody or an anti-body and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of prophylactically or therapeutically inhibiting IL-6 signaling in a mammal in need thereof, a mammal in need thereof, and a method of removing IL-6 ligand from a bodily fluid of an animal.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: December 16, 2003
    Assignee: The United States of America as represented by the Department of Health & Human Services
    Inventor: Carl Saxinger
  • Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
    Publication number: 20030068615
    Abstract: The present invention provides, among other things, a polypeptide that binds with the gp120 envelope protein of HIV, in particular HIV-1, under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a composition comprising such a polypeptide or nucleic acid or an antibody and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of making an antibody to gp120, and a method of removing HIV from a bodily fluid.
    Type: Application
    Filed: February 27, 2002
    Publication date: April 10, 2003
    Applicant: Department of Health and Human Services
    Inventor: Carl Saxinger
  • Automated Peptide design and synthesis
    Patent number: 6031074
    Abstract: An automated peptide design and synthesis method is provided, wherein peptides are synthesized on interior, inward facing surfaces of reservoirs formed in a solvent resistant substrate. Novel substrates, as well as novel solutions for storing protected carboxyl terminal amino acids, are also provided.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: February 29, 2000
    Assignee: National Institutes of Health
    Inventor: Carl Saxinger
  • Competitive ELISA for the detection of HTLV-III antibodies
    Patent number: 4661445
    Abstract: A competitive enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies is disclosed. This ELISA technique is more sensitive, more specific, and more accurate than known ELISA techniques. The competitive ELISA of this invention is particularly suited to the detection of human T-cell leukemia-lymphoma virus type III (HTLV-III). Antigenic or viral fragments are bound to a solid support. The bound fragments are then incubated with a heterologous antiserum which binds to the bound fragments. Test sera is then added to the bound fragments and tested for absorbance.
    Type: Grant
    Filed: May 24, 1985
    Date of Patent: April 28, 1987
    Inventors: W. Carl Saxinger, Robert C. Gallo