Abstract: The invention provides systems and components thereof for ultrasound-mediated drug delivery within the GI tract delivery of therapeutic agents to the gastrointestinal tract of a subject. The systems comprise a transmitter that includes a power source and power emitter for transmitting EM and non-EM energy. The power transmitter comprises one or more capacitive, inductive, magnetic resonance. RF, or ultrasonic energy radiator. The second component is an ingestible capsule that is physically separate from the transmitter. The ingestible capsule may be configured to harvest energy from the transmitter using a variety of components. In various embodiments, the ingestible pill comprises at least one energy harvesting component, an ultrasound transducer, and a reservoir or payload that releasably retains a liquid or powder mixture containing an encapsulated or non-encapsulated therapeutic agent.

Abstract: A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.

Abstract: The present invention provides for devices and methods that improve in vivo delivery of a drug to a target tissue by transmitting ultrasonic energy to a liquid comprising a drug at the site of the target tissue. The ultrasonic energy improves delivery of the drug to the target tissue.

Abstract: A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.

Abstract: The invention provides devices and methods for use with an endoscope to deliver an agent to an internal tissue of a subject. The devices and methods use transient acoustic cavitation to transfer an agent directly from a fluid to the tissue.

Abstract: The invention provides devices and methods for delivery of an agent to buccal tissue of a subject. The devices and methods use transient acoustic cavitation to transfer an agent directly from a fluid to buccal tissue.

Abstract: A method of delivering a recombinant virus to a skin tissue is provided. The method includes applying ultrasound to the skin tissue, and administering the recombinant virus to the skin tissue.

Abstract: A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.